Results 91 to 100 of about 411,726 (313)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian +6 more
wiley +1 more source
Modification of SPION Nanocarriers for siRNA Delivery: A Therapeutic Strategy Against HIV Infection
Vaccine Research, 2019 Introduction: To date, while many studies have investigated antiviral agents or vaccines against HIV, success has been limited. In this field, mutagenesis of the viral genome often contributes to viral escape from the antiretroviral therapies and the ...
Vahid Mobarakeh +4 more
doaj
Genetic Risk Score Enables a Vaccine for Early Primary Prevention of CAD
Methodist DeBakey Cardiovascular JournalEarly primary prevention of coronary artery disease (CAD) is limited by lack of biomarkers to detect CAD risk among young asymptomatic individuals. Although early prevention is more effective than secondary interventions, conventional risk factors such ...
Robert Roberts
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Precision medicine and nucleotide-based therapeutics to treat steatotic liver disease [PDF]
Clinical and Molecular HepatologyMetabolic dysfunction-associated steatotic liver disease (MASLD) is a complex multifactorial disease and becoming the leading cause of liver-related morbidity and mortality.
Andrea Caddeo, Stefano Romeo
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qPCR analysis of CLU expression demonstrates significant decrease in CLU expression after CLU siRNA knockdown (2A). As expected, VWF siRNA knockdown has no effect on CLU expression (2A).
Allaura A. Cox (17980027) +2 more
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β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Журнал микробиологии, эпидемиологии и иммунобиологииIntroduction. Among infectious lesions of the upper respiratory tract and lungs, the leading positions are occupied by infections associated with the influenza A virus.
Evgenij A. Pashkov +7 more
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Therapeutics and Clinical Risk Management, 2023 Stacy Dixon, Xuan Kang, Dianna Quan Department of Neurology, University of Colorado, Aurora, CO, USACorrespondence: Dianna Quan, Department of Neurology - University of Colorado, 12631 East 17th Avenue, Mailstop B185, Aurora, CO, 80045, USA, Tel +1 (303)
Dixon S, Kang X, Quan D
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Endosomal Escape of siRNA Polyplexes: A Molecular Dynamics Perspective on Underlying Mechanisms
Advanced Functional Materials, EarlyView.Molecular dynamics simulations reveal distinct endosomal escape mechanisms of siRNA nanoparticles, ranging from electrostatic membrane attachment to hydrophobic membrane fusion. Hydrophobic residues and anionic endosomal lipids emerge as key determinants of membrane disruption, linking molecular interactions to experimental delivery performance and ...
Katharina M. Steinegger +5 more
wiley +1 more source
siRNA-mediated knockdown of GluN3A mRNA in 46C-derived NSCs.
, 2018 46C-derived NSCs were either transfected with scrambled siRNA or siRNA directed against GluN3A. A: qRT-PCRs were performed to analyse the knockdown of GluN3A at the mRNA level.
Svenja Pachernegg (4849609) +6 more
core +1 more source