Results 101 to 110 of about 382,657 (316)

siRNA-mediated knockdown of AP-5 reduces plasma membrane localization and increases punctate distribution of HIV-2 Gag.

, 2016
(A) HeLa cells were transfected with 25 nM AP-5 siRNA or negative control siRNA (-ve), or mock transfected (none). Cells were harvested 42 hours post-transfection, from which RNA was isolated and RT-qPCR carried out to detect AP-5μ mRNA.
Emma C. Anderson (533572), Justine E. Alford (533570), Gemma L. Watkins (3156042), Michela Marongiu (3156045)   +3 more
core   +1 more source

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

Topical knockdown of HO-1 through siRNA improves skin wound healing in mice with radiation-wound combined injury

陆军军医大学学报
Objective To detect the expression profile of heme oxygenase-1 (HO-1) during the process of wound repair in radiation-wound combined injury (R-W-CI), and evaluate its wound healing improving effects of R-W-CI by HO-1 knockdown with siRNA. Methods A total
LYU Xiaofan, WANG Guojian, ZHAO Na
doaj   +1 more source

siRNA-mediated knockdown of AP-5 affects HIV-2 but not HIV-1 Gag.

, 2016
HeLa cells were co-transfected with HIV-1 (A, B) or HIV-2 (C, D) proviral plasmids and no siRNA (none), siRNA against AP-5μ or a negative control siRNA (-ve). 42 hours post-transfection, cell lysates and viral supernatants were harvested. Cell-associated
Emma C. Anderson (533572), Justine E. Alford (533570), Gemma L. Watkins (3156042), Michela Marongiu (3156045)   +3 more
core   +1 more source

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Targeted Inhibition of HK-II Reversed the Warburg Effect to Improve the Radiosensitivity of Laryngeal Carcinoma

Cancer Management and Research, 2021
Xiao-Hong Chen,1 Ding-Li Yu,2 Jiang-Tao Zhong,2 Shui-Hong Zhou,2 Jun Fan,3 Zhong-Jie Lu4 1Department of Otolaryngology, The Second Hospital of Jiaxing (The Second Affiliated Hospital, Jiaxing University), Jiaxing City, Zhejiang Province, 314000, People’s
Chen XH, Yu DL, Zhong JT, Zhou SH, Fan J, Lu ZJ   +5 more
doaj  

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Selective suppression of influenza A/H5N1 virus replication in vitro using nanocomplexes consisting of siRNA and aminopropylsilanol nanoparticles

Журнал микробиологии, эпидемиологии и иммунобиологии
Relevance. Studies on model systems have confirmed the effectiveness of antisense oligonucleotides, including those that contain photoactive groups, for the modification of nucleic acids.
Marina N. Repkova, Asya S. Levina, Oleg Yu. Mazurkov, Elena V. Makarevich, Ekaterina I. Filippova, Natalya A. Mazurkova, Valentina F. Zarytova   +6 more
doaj   +1 more source

siRNA-based knockdown of CLU results in decreased VWF and CLU protein expression but no change in VWF mRNA content.

qPCR analysis of CLU expression demonstrates significant decrease in CLU expression after CLU siRNA knockdown (2A). As expected, VWF siRNA knockdown has no effect on CLU expression (2A).
Allaura A. Cox (17980027), Alice Liu (4814415), Christopher J. Ng (14290358)   +2 more
core   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source