Results 101 to 110 of about 411,726 (313)
Advanced Healthcare Materials, EarlyView.Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj +23 more
wiley +1 more source
Molecular and Genetic Aspects of Lipid Metabolism Disorders and Potential Targets for Gene Therapy
Journal of Lipid and AtherosclerosisDiseases associated with impaired lipid metabolism are major contributors to the rising global burden of cardiovascular disease. Over the past several decades, cardiovascular diseases have consistently remained the leading cause of mortality and ...
Elvira R. Akhmetzyanova +4 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Prostate patient‐derived organoids (PDOs) were established from TURP and biopsy specimens with >90% success and retain key features of their tissues of origin, making them functional avatars for antisense oligonucleotide (ASO) therapy . Transfecting single cells outside the Matrigel matrix and then reconstituting organoids overcomes the 3D delivery ...
Thi Thom Tran +15 more
wiley +1 more source
Targeted siRNA Therapy for Psoriasis: Translating Preclinical Potential into Clinical Treatments
ImmunoTargets and TherapyFuyu Zhao,1– 3,* Jianan Zhao,1– 3,* Kai Wei,1– 3 Ping Jiang,1– 3 Yiming Shi,1– 3 Cen Chang,1– 3 Yixin Zheng,1– 3 Yu Shan,1– 3 Yunshen Li,1– 3 Bingheng He,4 Mi Zhou,1,3 Jia Liu,1,3 Li Li,1,3 Shicheng Guo,1 Dongyi He1– 3 1Department of Rheumatology,
Zhao F +14 more
doaj
Hemocompatible Glycogen‐Tissue Plasminogen Activator Complexes for Enhanced Blood Clot Dissolution
Advanced Healthcare Materials, EarlyView.Glycogen–heparin‐cRGD nanoparticles enable targeted delivery of tissue plasminogen activator (tPA) to thrombi through activated platelet recognition. The hemocompatible hybrids minimize interactions with blood and immune cells while retaining enzymatic biodegradability.
Nadiia Davydiuk +6 more
wiley +1 more source
Forestry Research24-nt siRNA-directed DNA methylation is crucial for heterosis in herbaceous plants, but its regulatory function, particularly 24-nt phasiRNA (phased small RNA)-mediated DNA methylation, remains unexplored. This study analyzed whole-genome DNA methylation
Jing Zhang +7 more
doaj +1 more source
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
Advanced Materials, EarlyView.Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol +16 more
wiley +1 more source
陆军军医大学学报Objective To detect the expression profile of heme oxygenase-1 (HO-1) during the process of wound repair in radiation-wound combined injury (R-W-CI), and evaluate its wound healing improving effects of R-W-CI by HO-1 knockdown with siRNA. Methods A total
LYU Xiaofan, WANG Guojian, ZHAO Na
doaj +1 more source
siRNA-mediated knockdown of ZBP1 reduces expression in human macrophages.
Immunoblot analysis of Z-DNA binding protein 1 (ZBP1; p68) expression in human macrophages treated with non-targeting siRNA (siControl) or human-specific ZBP1 siRNA (siZBP1). β-actin was used as a loading control.
Sk Mohiuddin Choudhury (18065118) +3 more
core +1 more source