Results 111 to 120 of about 535,239 (304)
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Current Development of siRNA Bioconjugates: From Research to the Clinic
Frontiers in Pharmacology, 2019 Small interfering RNAs (siRNAs) acting via RNA interference mechanisms are able to recognize a homologous mRNA sequence in the cell and induce its degradation.
I. V. Chernikov +2 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo +7 more
wiley +1 more source
STUDY OF MODIFIED RECOMBINANT APOLIPOPROTEIN A-I AS A CARRIER OF SMALL INTERFERRING RNA
Сибирский научный медицинский журнал, 2019 With the widespread development of the phenomenon of RNA interference, currently, researchers are puzzled to obtain effective carriers of small interfering RNA (siRNA).
A. V. Ryabchenko +4 more
doaj +1 more source
Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery
Advanced Functional Materials, EarlyView.A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon +5 more
wiley +1 more source
Modification of SPION Nanocarriers for siRNA Delivery: A Therapeutic Strategy Against HIV Infection
Vaccine Research, 2019 Introduction: To date, while many studies have investigated antiviral agents or vaccines against HIV, success has been limited. In this field, mutagenesis of the viral genome often contributes to viral escape from the antiretroviral therapies and the ...
Vahid Mobarakeh +4 more
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Genetic Risk Score Enables a Vaccine for Early Primary Prevention of CAD
Methodist DeBakey Cardiovascular JournalEarly primary prevention of coronary artery disease (CAD) is limited by lack of biomarkers to detect CAD risk among young asymptomatic individuals. Although early prevention is more effective than secondary interventions, conventional risk factors such ...
Robert Roberts
doaj +1 more source
Precision medicine and nucleotide-based therapeutics to treat steatotic liver disease [PDF]
Clinical and Molecular HepatologyMetabolic dysfunction-associated steatotic liver disease (MASLD) is a complex multifactorial disease and becoming the leading cause of liver-related morbidity and mortality.
Andrea Caddeo, Stefano Romeo
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj +23 more
wiley +1 more source
Therapeutics and Clinical Risk Management, 2023 Stacy Dixon, Xuan Kang, Dianna Quan Department of Neurology, University of Colorado, Aurora, CO, USACorrespondence: Dianna Quan, Department of Neurology - University of Colorado, 12631 East 17th Avenue, Mailstop B185, Aurora, CO, 80045, USA, Tel +1 (303)
Dixon S, Kang X, Quan D
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