Results 111 to 120 of about 382,657 (316)

Preparation of Bmi-1-siRNA Lipid Nanoparticles and Effects in Gastric Cancer

Nano Biomedicine and Engineering
Malignant tumors remain a serious threat to human health and life and are a major public health problem globally. Herein, we designed and synthesized a novel nucleic acid nanomedicine AS1411-siRNA-LNPs (As@LNPs).
Hongzhang Yan, Hong Shen, Jinrong SiTu, Yingying Yang, Lingle Zhang, Kai Yang   +5 more
doaj   +1 more source

Physiological role of Prion Protein in Copper homeostasis and angiogenic mechanisms of endothelial cells

The EuroBiotech Journal, 2019
The Prion Protein (PrP) is mostly known for its role in prion diseases, where its misfolding and aggregation can cause fatal neurodegenerative conditions such as the bovine spongiform encephalopathy and human Creutzfeldt–Jakob disease.
De Riccardis Lidia, Rizzo Francesca, Urso Emanuela, Garzarelli Valeria, Intini Vincenza, Greco Marco, Maffia Maria Chiara, Danieli Antonio, Maffia Michele   +8 more
doaj   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Codelivery of DOX and siRNA by folate-biotin-quaternized starch nanoparticles for promoting synergistic suppression of human lung cancer cells

Drug Delivery, 2019
In this paper, the self-assembled folate-biotin-quaternized starch nanoparticles (FBqS NPs) were used as carrier system of doxorubicin (DOX) and siRNAIGF1R for the codelivery of both into human lung adenocarcinoma cell lines (A549 cells) in vitro.
Liangping Li, Suoju He, Lizhen Yu, Ezzat H Elshazly, Hui Wang, Kuanmin Chen, Song Zhang, Lixia Ke, Renmin Gong   +8 more
doaj   +1 more source

siRNA-mediated knockdown of ZBP1 reduces expression in human macrophages.

Immunoblot analysis of Z-DNA binding protein 1 (ZBP1; p68) expression in human macrophages treated with non-targeting siRNA (siControl) or human-specific ZBP1 siRNA (siZBP1). β-actin was used as a loading control.
Sk Mohiuddin Choudhury (18065118), Roman Sarkar (10583678), Rajendra Karki (460028), Thirumala-Devi Kanneganti (62745)   +3 more
core   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Therapeutic siRNAs: small molecules with bigger function

Asian Journal of Medical Sciences
In the realm of molecular medicine, therapeutic small-interfering RNA (siRNA) is a promising class of molecules with exciting new opportunities in healthcare. An essential component of RNA interference (RNAi) is siRNA.
Ruby Dhar , Arun Kumar , Subhradip Karmakar   +2 more
doaj   +1 more source

siRNA-mediated knockdown of RIPK3 reduces expression in human macrophages.

Immunoblot analysis of phosphorylated receptor-interacting protein kinase 3 (pRIPK3) and total RIPK3 (tRIPK3) expression in human macrophages treated with non-targeting siRNA (siControl) or human-specific RIPK3 siRNA (siRIPK3), followed by treatment with
Sk Mohiuddin Choudhury (18065118), Roman Sarkar (10583678), Rajendra Karki (460028), Thirumala-Devi Kanneganti (62745)   +3 more
core   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Synthetic small interfering RNAs selectively suppress the expression of proinflammatory cytokine genes (IL-25 and TSLP) in experiments in vitro

Медицинская иммунология
Allergic rhinitis (AR) is an inflammatory disease of the upper respiratory tract (nasal mucosa). AR affects up to 40% of the world’s population; in the Russian Federation, the incidence is 18% to 30%, depending on the region.
M. M. Kaganova, I. P. Shilovskiy, E. D. Timotievich, K. V. Yumashev, D. A. Gurskii, K. V. Vinogradova, M. V. Popova, M. R. Khaitov   +7 more
doaj   +1 more source