Results 131 to 140 of about 528,585 (356)

Therapeutic siRNAs: small molecules with bigger function

Asian Journal of Medical Sciences
In the realm of molecular medicine, therapeutic small-interfering RNA (siRNA) is a promising class of molecules with exciting new opportunities in healthcare. An essential component of RNA interference (RNAi) is siRNA.
Ruby Dhar , Arun Kumar , Subhradip Karmakar   +2 more
doaj   +1 more source

Recent Advances and Challenges in Gene Delivery Mediated by Polyester-Based Nanoparticles

International Journal of Nanomedicine, 2021
Anna Piperno,1 Maria Teresa Sciortino,1 Elena Giusto,2 Monica Montesi,2 Silvia Panseri,2 Angela Scala1 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy; 2CNR-ISTEC, Institute of Science
Piperno A, Sciortino MT, Giusto E, Montesi M, Panseri S, Scala A   +5 more
doaj  

Modular and hierarchical self-assembly of siRNAs into supramolecular nanomaterials for soft and homogeneous siRNA loading and precise and visualized intracellular delivery

, 2022
Xiaowen Guan, Fan-Qi Meng, Hongwei Tan, Xiaoni Wang, Jinɡjinɡ Li, Juanjuan Wei, Jin Ouyang, Na Na   +7 more
openalex   +2 more sources

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Synthetic small interfering RNAs selectively suppress the expression of proinflammatory cytokine genes (IL-25 and TSLP) in experiments in vitro

Медицинская иммунология
Allergic rhinitis (AR) is an inflammatory disease of the upper respiratory tract (nasal mucosa). AR affects up to 40% of the world’s population; in the Russian Federation, the incidence is 18% to 30%, depending on the region.
M. M. Kaganova, I. P. Shilovskiy, E. D. Timotievich, K. V. Yumashev, D. A. Gurskii, K. V. Vinogradova, M. V. Popova, M. R. Khaitov   +7 more
doaj   +1 more source

Abstract 2460: Development of a highly-sensitive RT-qPCR assay for the detection and quantitation of siRNAs to further understand their role in mRNA quality control in Caenorhabditis elegans

, 2023
Juliane Castellani, Elaine M. Youngman
openalex   +1 more source

siRNA [PDF]

Chemistry & Biology, 2002
Ramaswamy, Gopalakrishna, Slack, Frank J
openaire   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Restoration of Mir-185 in Combination with BCR-ABL Downregulation By Therapeutic Delivery of siRNA with Lipid Nanoparticle Carriers Targets Drug Resistant Leukemic Stem/Progenitor Cells [PDF]

, 2023
Athena Phoa, Min Chen, Xiaoyan Jiang
openalex   +1 more source

Engineering Resatorvid‐Loaded Sub‐Microgels of Epigallocatechin‐3‐gallate/Hyaluronic Acid to Treat Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
This study presents HAEP@Res sub‐microgels as a lung‐targeted delivery system integrating antioxidant activity with anti‐inflammatory therapy. The sub‐microgels demonstrate excellent biocompatibility, efficiently scavenge intracellular ROS, and downregulate pro‐inflammatory cytokines and genes in a Bleo‐induced ALI mouse model. These findings highlight
Bo Liu, Olawale Alimi Alimi, Benjamin Stearnes, Svetlana Romanova, Brady J. Sillman, Mena Asha Krishnan, Kristina Bailey, Benson J. Edagwa, Huanhuan Joyce Chen, Han‐jun Wang, Bin Duan   +10 more
wiley   +1 more source