Results 121 to 130 of about 535,239 (304)

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

Molecular Therapy, 2018
Significant progress has been made in the advancement of RNAi therapeutics by combining a synthetic triantennary N-acetylgalactosamine ligand targeting the asialoglycoprotein receptor with chemically modified small interfering RNA (siRNA) designs ...
Donald J. Foster, Christopher R. Brown, Sarfraz Shaikh, Casey Trapp, Mark K. Schlegel, Kun Qian, A. Sehgal, K. G. Rajeev, V. Jadhav, M. Manoharan, S. Kuchimanchi, M. Maier, S. Milstein   +12 more
semanticscholar   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Impairment of influenza A virus reproduction in vivo with siRNA-induced silencing of the NXF1, PRPS1 and NAA10 cellular genes

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Among infectious lesions of the upper respiratory tract and lungs, the leading positions are occupied by infections associated with the influenza A virus.
Evgenij A. Pashkov, George A. Pashkov, Firaya G. Nagieva, Alena A. Murzina, Irina B. Semenova, Galina N. Usatova, Oxana A. Svitich, Vitaliy V. Zverev   +7 more
doaj   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

24-nt-phasiRNA associated CHG/CHH DNA methylation contributes to growth heterosis of Populus deltoides

Forestry Research
24-nt siRNA-directed DNA methylation is crucial for heterosis in herbaceous plants, but its regulatory function, particularly 24-nt phasiRNA (phased small RNA)-mediated DNA methylation, remains unexplored. This study analyzed whole-genome DNA methylation
Jing Zhang, Weixi Zhang, Changjun Ding, Qi Liu, Zhengsai Yuan, Lulan Miao, Yanguang Chu, Xiaohua Su   +7 more
doaj   +1 more source

siRNA-mediated knockdown of GluN3A mRNA in 46C-derived NSCs.

, 2018
46C-derived NSCs were either transfected with scrambled siRNA or siRNA directed against GluN3A. A: qRT-PCRs were performed to analyse the knockdown of GluN3A at the mRNA level.
Svenja Pachernegg (4849609), Hendrik Schöneborn (4849612), Sebastian Neumann (75745), Elke Eilebrecht (4849603), Sebastian Eilebrecht (4849606), Arndt G. Benecke (437289), Michael Hollmann (176278)   +6 more
core   +1 more source

siRNA Versus miRNA as Therapeutics for Gene Silencing

Molecular Therapy: Nucleic Acids, 2015
Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs (miRNAs) are noncoding RNAs with important roles in gene regulation.
J. Lam, Michael Y. T. Chow, Yu Zhang, S. Leung   +3 more
semanticscholar   +1 more source

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

Targeted siRNA Therapy for Psoriasis: Translating Preclinical Potential into Clinical Treatments

ImmunoTargets and Therapy
Fuyu Zhao,1– 3,* Jianan Zhao,1– 3,* Kai Wei,1– 3 Ping Jiang,1– 3 Yiming Shi,1– 3 Cen Chang,1– 3 Yixin Zheng,1– 3 Yu Shan,1– 3 Yunshen Li,1– 3 Bingheng He,4 Mi Zhou,1,3 Jia Liu,1,3 Li Li,1,3 Shicheng Guo,1 Dongyi He1– 3 1Department of Rheumatology,
Zhao F, Zhao J, Wei K, Jiang P, Shi Y, Chang C, Zheng Y, Shan Y, Li Y, He B, Zhou M, Liu J, Li L, Guo S, He D   +14 more
doaj  

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source