Results 61 to 70 of about 117,912 (291)

Acute sirolimus overdose: a multicenter case series. [PDF]

PLoS ONE, 2015
There are few data relating to sirolimus overdose in the medical literature. Our objectives were to describe all cases of overdose with sirolimus reported to Swiss, German and Austrian Poisons Centres between 2002-2013.An observational case-series ...
Alessandro Ceschi, Elja Heistermann, Sonja Gros, Cornelia Reichert, Hugo Kupferschmidt, Nicholas R Banner, Stephan Krähenbühl, Anne B Taegtmeyer   +7 more
doaj   +1 more source

Antilymphoid antibody preconditioning and tacrolimus monotherapy for pediatric kidney transplantation [PDF]

, 2006
Objective: Heavy post-transplant immunosuppression may contribute to long-term immunosuppression dependence by subverting tolerogenic mechanisms; thus, we sought to determine if this undesirable consequence could be mitigated by pretransplant lymphoid ...
Abhay N. Vats, Adrianna Zeevi, Akhtar S. Khan, Amadeo Marcos, Amit Basu, Bartosh, Calne, Calne, Chakrabarti, Corde McFeaters, Demetrius Ellis, Edward A. Gray, Fine, Gerri James, Halloran, Henkie P. Tan, Jensen, Kirk, Knechtle, Lilly, Mary Jo Grosso, McCurry, Michael L. Moritz, Mueller, Najarian, Nankivell, Purighalla, Randhawa, Reyes, Riley, Ron Shapiro, Sarwal, Shapiro, Shapiro, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Stuart, Thomas E. Starzl, Todo, Waldmann, Williams   +52 more
core   +1 more source

Efficacy of systemic sirolimus in the treatment of generalized lymphatic anomaly and Gorham–Stout disease

Pediatric Blood & Cancer, 2019
Generalized lymphatic anomaly (GLA) and Gorham–Stout disease (GSD) are rare complicated lymphatic malformations that occur in multiple body sites and are associated with significant morbidity and mortality.
Kiersten W Ricci, A. Hammill, P. Mobberley-Schuman, S. Nelson, J. Blatt, J. Bender, C. McCuaig, Anna Synakiewicz, I. Frieden, D. Adams   +9 more
semanticscholar   +1 more source

Syndrome of the Month: An Update on Smith‐Kingsmore Syndrome: Characterization of Developmental Milestones and a Review of the Literature

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Smith‐Kingsmore syndrome (SKS) is a rare autosomal dominant condition characterized by neurodevelopmental differences, macrocephaly/megalencephaly, describable facial features, sleep–wake abnormalities, hyperphagia, and overgrowth. SKS is caused by pathogenic gain‐of‐function variants in MTOR which lead to hyperactivation of the mTOR pathway ...
Carolyn R. Raski, Carlos E. Prada
wiley   +1 more source

The use of sirolimus in patients with recurrent cytomegalovirus infection after kidney transplantation: A retrospective case series analysis

Saudi Journal of Kidney Diseases and Transplantation, 2019
Cytomegalovirus (CMV) is one of opportunistic infections post solid organ transplant and remains a cause of morbidity and mortality. Mammalian target of rapamycin inhibitors has a theoretical antiviral advantage compared to conventional immunosuppression.
Ali M Shendi, Rachel K. Y Hung, Ben Caplin, Paul Griffiths, Mark Harber   +4 more
doaj   +1 more source

Liver transplantation [PDF]

, 2014
Purpose of review: Long-term survival of liver transplant recipients is threatened by increased rates of de-novo malignancy and recurrence of hepatocellular carcinoma (HCC), both events tightly related to immunosuppression.
Burroughs, AK, De la Mata, M, Rodríguez-Perálvarez, M   +2 more
core  

Emotions and scope effects in the monetary valuation of health [PDF]

, 2018
JEL classifications: H41 H51 I11 I18 I31This study presents evidence on the role of emotions in the monetary evaluation of health technologies, namely, drug-eluting stents (DES) in our case.
Araña, Jorge, Avilés Blanco, Maria V., Brey, Raúl, Pinto Prades, Jose Luis   +3 more
core   +1 more source

Activity of sirolimus in patients with progressive epithelioid hemangioendothelioma: A case‐series analysis within the Italian Rare Cancer Network

Cancer, 2020
The objective of this study was to report on a retrospective series of patients with epithelioid hemangioendothelioma (EHE) who received treatment with sirolimus within the Italian Rare Cancer Network.
S. Stacchiotti, N. Simeone, S. Lo Vullo, G. Baldi, A. Brunello, B. Vincenzi, E. Palassini, G. Dagrada, P. Collini, C. Morosi, F. Greco, M. Sbaraglia, A. D. Dei Tos, L. Mariani, A. Frezza, P. Casali   +15 more
semanticscholar   +1 more source

Gamma Irradiation of Poly(lactide‐co‐glycolide) Scaffolds Reduces the Mechanical Stability and Function of Islet Grafts in Diabetic Nonhuman Primates

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Clinical islet transplantation has long been investigated as a potential cure for type 1 diabetes (T1D), yet standard intrahepatic delivery leaves islets prone to an instant blood‐mediated inflammatory response. Herein, we investigated the design of microporous poly(D,l‐lactide‐co‐glycolide) (PLG) scaffolds for extrahepatic islet ...
Jessica L. King, Christopher Spencer, Richard Youngblood, Kelly Crumley, Elizabeth Bealer, Peter D. Rios, Ira Joshi, Sofia Ghani, Douglas Isa, James J. McGarrigle, David Cook, Conor Locke, Adam Abraham, Andrea Clark, José Oberholzer, Lonnie D. Shea   +15 more
wiley   +1 more source

Comparative acute toxicity of intravenous paclitaxel and sirolimus in rats

Current Research in Toxicology
Aim: In view of the exploration of sirolimus (rapamycin) as balloon coating for peripheral intravasal treatment and the reports on unfavorable tolerance of daily low-dose sirolimus, the aim of the study was to investigate potential toxicological effects ...
Jing Xie, Denise Schuett, Ulrich Speck, Tobias Haase   +3 more
doaj   +1 more source