Results 61 to 70 of about 62,260 (164)
Transplant Infectious Disease, EarlyView.This retrospective case series of acyclovir‐resistant HSV infection in pediatric patients undergoing allogeneic HSCT discusses the clinical course, associated complications, and treatment, including side effects. We propose the first algorithm for investigating and managing acyclovir‐resistant HSV infections in pediatric HSCT recipients, highlighting ...
Jenna Nunn +9 more
wiley +1 more source
An unusual cause of cancer mimicry following liver transplantation
Annals of Hepatology, 2012 Sirolimus is an approved anti-rejection agent following liver or kidney transplantation that works through inhibition of the mammalian target of rapamycin (mTOR). As sirolimus functions through a pathway independent of calcineurin inhibition, it may have
Karim Qumosani, Natasha Chandok
doaj +1 more source
Transplant Infectious Disease, EarlyView.Third‐party, BK virus‐specific cytotoxic T lymphocytes (CTLs) were safe and effective in reducing viremia in kidney and stem cell transplant recipients with BK virus nephropathy. However, they did not improve kidney function. Earlier administration may be more beneficial before nephropathy and irreversible damage occur.
Amanda Olson +18 more
wiley +1 more source
HHV‐8/KSHV in Solid Organ Transplantation: Current Gaps of Knowledge and Future Directions
Transplant Infectious Disease, EarlyView.Risk mitigation strategies, including donors/recipients screening, DNAemia monitoring in recipients at risk, CNI‐to‐mTOR inhibitors switch, antivirals, and rituximab for KICS, may mitigate the impact of HHV‐8/KSHV infection in SOT. This review provides an update on KICS, identifies research gaps, and summarizes advances in screening and management ...
Alessandra Mularoni +9 more
wiley +1 more source
Facial angiofibromas of tuberous sclerosis treated with topical sirolimus in an Indian patient
Indian Journal of Dermatology, 2015 Facial angiofibromas are the most visible and unsightly of all the cutaneous manifestations of tuberous sclerosis (TSC). A 17-year-old female, a known case of TSC, presented for the treatment of cosmetically disfiguring facial angiofibromas.
Resham J Vasani
doaj +1 more source
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Jakob Veeser +11 more
wiley +1 more source
American Journal of Medical Genetics Part A, Volume 200, Issue 4, Page 800-806, April 2026.ABSTRACT Smith‐Kingsmore syndrome (SKS) is a rare autosomal dominant condition characterized by neurodevelopmental differences, macrocephaly/megalencephaly, describable facial features, sleep–wake abnormalities, hyperphagia, and overgrowth. SKS is caused by pathogenic gain‐of‐function variants in MTOR which lead to hyperactivation of the mTOR pathway ...
Carolyn R. Raski, Carlos E. Prada
wiley +1 more source
Effect of sirolimus on urinary bladder cancer T24 cell line
Journal of Experimental & Clinical Cancer Research, 2009 Background Sirolimus is recently reported to have antitumour effects on a large variety of cancers. The present study was performed to investigate sirolimus's ability to inhibit growth in T24 bladder cancer cells.
Oliveira Paula A +4 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 891-904, April 2026.Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi +6 more
wiley +1 more source