Results 61 to 70 of about 82,161 (336)
Frontiers in Pharmacology, 2021 The purposes of this study were to explore the population pharmacokinetics and initial dose optimization of sirolimus improving drug blood level for seizure control in pediatric patients with tuberous sclerosis complex (TSC).
Xiao Chen +10 more
doaj +1 more source
South African Medical Journal, 2016 Sirolimus is an inhibitor of the mammalian target of rapamycin (mTOR), used as an immunosuppressant for solid-organ transplant recipients and patients with autoimmune disorders. We report a case of lymphoedema, a rare complication of sirolimus, and discuss the mechanism of drug action, the adverse effects and the challenges of treating a kidney ...
Kagiso G Motse, Mduduzi J Mashabane
openaire +4 more sources
Pneumopathie médicamenteuse sous sirolimus : interaction avec l’atorvastatine ? [PDF]
, 2012 Introduction Sirolimus is an immunosupressant used in renal transplantation because of its lack of nephrotoxicity. We report four cases of pneumonitis due to sirolimus, possibly revealing an interaction with atorvastatin.
A. Foulet-Rogé +6 more
core +3 more sources
Orphanet Journal of Rare Diseases, 2018 BackgroundExtensive and complex vascular malformations often cause chronic pain and severe functional restraint. Conventional treatments, such as surgery and/or sclerotherapy, are rarely curative, underscoring the great need for new therapeutic ...
J. Hammer +11 more
semanticscholar +1 more source
Cardiovascular morbidity and mortality after kidney transplantation [PDF]
, 2014 Kidney transplantation is the optimal treatment for patients with end stage renal disease (ESRD) who would otherwise require dialysis. Patients with ESRD are at dramatically increased cardiovascular (CV) risk compared to the general population.
Jardine, Alan G. +2 more
core +1 more source
Orphanet Journal of Rare Diseases, 2019 BackgroundLymphatic anomalies (LAs) include several disorders in which abnormal lymphatic tissue invades the neck, chest, and various organs. Progressive cases may result in lethal outcomes and have proven difficult to treat.
M. Ozeki +6 more
semanticscholar +1 more source
mTOR inhibitor reduces nontumour-related death in liver transplantation for hepatocellular carcinoma
Molecular BiomedicineSirolimus is a regularly applied immunosuppressant for patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). Sirolimus not only significantly inhibits HCC recurrence but also protects renal function.
Lincheng Zhang +14 more
doaj +1 more source
Development and Physicochemical Characterization of Sirolimus Solid Dispersions Prepared by Solvent Evaporation Method [PDF]
Advanced Pharmaceutical Bulletin, 2014 Purpose: The aim of the present investigation was preparation and characterization of sirolimus solid dispersions by solvent evaporation technique to improve its dissolution properties.
Shahram Emami +3 more
doaj +1 more source
Advanced Functional Materials, EarlyView.Joule‐assisted nanotherapeutic urethral stent harnesses a smart, biodegradable magnesium stent to orchestrate spatiotemporal theragenerative therapy for urethral strictures. Magnetically induced Joule heating enables on‐demand drug release and bacterial ablation, while simultaneously guiding urothelial regeneration.
Yuhyun Na +15 more
wiley +1 more source
Bioactive Materials, 2020 Pharmacokinetic analyses were performed using 20 pigs for 120-days implantation, while one sirolimus-eluting stent was implanted into one of their coronary artery.
Shanshan Chen +8 more
doaj