Results 11 to 20 of about 10,371 (142)

'Clustering' SIRPα into the plasma membrane lipid microdomains is required for activated monocytes and macrophages to mediate effective cell surface interactions with CD47. [PDF]

PLoS ONE, 2013
SIRPα, an ITIMs-containing signaling receptor, negatively regulates leukocyte responses through extracellular interactions with CD47. However, the dynamics of SIRPα-CD47 interactions on the cell surface and the governing mechanisms remain unclear.
Binh Ha, Zhiyuan Lv, Zhen Bian, Xiugen Zhang, Aarti Mishra, Yuan Liu   +5 more
doaj   +1 more source

Anomalous Levels of CD47/Signal Regulatory Protein Alpha in the Hippocampus Lead to Excess Microglial Engulfment in Mouse Model of Perioperative Neurocognitive Disorders

Frontiers in Neuroscience, 2022
BackgroundPerioperative neurocognitive disorders (PNDs) are common complications of surgical patients, which can lead to prolonged hospitalization, increased complications, and decreased independence and quality of life. However, the underlying molecular
Min Shui, Yi Sun, Dandan Lin, Ziyi Xue, Jianhui Liu, Anshi Wu, Changwei Wei   +6 more
doaj   +1 more source

Modified exosomal SIRPα variants alleviate white matter injury after intracerebral hemorrhage via microglia/macrophages

Biomaterials Research, 2022
Background Despite limited efficiency, modulation of microglia/macrophages has shown to attenuate neuroinflammation after intracerebral hemorrhage (ICH).
Xinjie Gao, Heng Yang, Weiping Xiao, Jiabin Su, Yuwen Zhang, He Wang, Wei Ni, Yuxiang Gu   +7 more
doaj   +1 more source

Tumor-associated macrophages and macrophage-related immune checkpoint expression in sarcomas

OncoImmunology, 2020
Early trials for immune checkpoint inhibitors in sarcomas have delivered mixed results, and efforts to improve outcomes now look to combinatorial strategies with novel immunotherapeutics, including some that target macrophages.
Amanda R. Dancsok, Dongxia Gao, Anna F. Lee, Sonja Eriksson Steigen, Jean-Yves Blay, David M. Thomas, Robert G. Maki, Torsten O. Nielsen, Elizabeth G. Demicco   +8 more
doaj   +1 more source

Structural analysis and binding sites of inhibitors targeting the CD47/SIRPα interaction in anticancer therapy

Computational and Structural Biotechnology Journal, 2021
Cluster of differentiation 47 (CD47)/signal regulatory protein alpha (SIRPα) is a negative innate immune checkpoint signaling pathway that restrains immunosurveillance and immune clearance, and thus has aroused wide interest in cancer immunotherapy ...
Bo Huang, Zhaoshi Bai, Xinyue Ye, Chenyu Zhou, Xiaolin Xie, Yuejiao Zhong, Kejiang Lin, Lingman Ma   +7 more
doaj   +1 more source

SIRPα blockade improves the antitumor immunity of radiotherapy in colorectal cancer

Cell Death Discovery, 2023
High-dose hypofractionated radiotherapy (HRT) is an important anticancer treatment modality that activates antitumor host immune responses. However, HRT for oligometastases of colorectal cancer (CRC) has shown frustrating results in the clinic.
Kai Ji, Yuhan Zhang, Shengpeng Jiang, Lin Sun, Baozhong Zhang, Dongzhi Hu, Jun Wang, Lujun Zhao, Ping Wang, Zhen Tao   +9 more
doaj   +1 more source

Non-Hematopoietic and Hematopoietic SIRPα Signaling Differently Regulates Murine B Cell Maturation in Bone Marrow and Spleen. [PDF]

PLoS ONE, 2015
B lymphocyte development occurs in the bone marrow, while final differentiation and maturation can occur in both the bone marrow and the spleen. Here we provide evidence that signal regulatory protein α (SIRPα), an Ig-superfamily ITIM-receptor expressed ...
Shrikant Shantilal Kolan, Kristina Lejon, Cecilia Koskinen Holm, Rima Sulniute, Pernilla Lundberg, Takashi Matozaki, Per-Arne Oldenborg   +6 more
doaj   +1 more source

SIRPα-αCD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cells

Journal of Hematology & Oncology, 2021
Background Acute myeloid leukaemia (AML) stem cells (LSCs) cause disease relapse. The CD47 “don’t eat me signal” is upregulated on LSCs and contributes to immune evasion by inhibiting phagocytosis through interacting with myeloid-specific signal ...
Siret Tahk, Binje Vick, Björn Hiller, Saskia Schmitt, Anetta Marcinek, Enrico D. Perini, Alexandra Leutbecher, Christian Augsberger, Anna Reischer, Benjamin Tast, Andreas Humpe, Irmela Jeremias, Marion Subklewe, Nadja C. Fenn, Karl-Peter Hopfner   +14 more
doaj   +1 more source

The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2 [PDF]

, 2016
Plasmacytoid dendritic cells (DCs [pDCs]) develop from pre-pDCs, whereas two lineages of conventional DCs (cDCs; cDC1s and cDC2s) develop from lineage-committed pre-cDCs.
Bachem, Bajaña, Bart N. Lambrecht, Bieke Soen, Broos, Broos, Caton, Cerovic, Charlotte L. Scott, Cisse, Danny Huylebroeck, De Craene, Denecker, Dominguez, Edelson, Geert Berx, Gert Van Isterdael, Ghosh, Gillian Blancke, Goossens, Grajales-Reyes, Greter, Guilliams, Hacker, Haniffa, Hegarty, Helft, Higashi, Hildner, Jackson, Joachim Taminau, Jody Haigh, Kashiwada, Lewis, Li, Liesbet Martens, Liu, Martin Guilliams, Merad, Miller, Murphy, Naik, Nicolas Skrypek, Omilusik, Onai, Persson, Persson, Remacle, Satpathy, Schlitzer, Schlitzer, Scott, Scott, Spits, Swiecki, Tailor, Tamura, Tatari, Tussiwand, van Helden, Welty, Williams, Wouter Saelens, Wu, Yvan Saeys   +64 more
core   +2 more sources

Signal regulatory protein alpha (SIRPα) regulates the homeostasis of CD103⁺CD11b⁺ DCs in the intestinal lamina propria [PDF]

, 2014
Signal regulatory protein alpha (SIRP alpha/CD172a) is a conserved transmembrane protein thought to play an inhibitory role in immune function by binding the ubiquitous ligand CD47.
Bain, Bain, Barclay, Barclay, Basu, Bimczok, Bogunovic, Cerovic, Cerovic, Coombes, del Rio, Fortin, Fukunaga, Goto, Inagaki, Iwamura, Kanazawa, Latour, Lewis, Lindberg, Liu, Lécuyer, Matozaki, Matteoli, Milling, Motegi, Naik, Okuzawa, Pabst, Persson, Persson, Raymond, Raymond, Saito, Satpathy, Schlitzer, Schraml, Schulz, Scott, Scott, Sun, Takai, Tamoutounour, Tomizawa, Varol, Waclavicek, Watchmaker, Welty, Westlund   +48 more
core   +2 more sources