Results 51 to 60 of about 10,371 (142)

Research Progress of CD47-SIRPα Signaling Axis as An Innate Immune Checkpoint in Cancer

Zhongliu Fangzhi Yanjiu, 2018
Immune checkpoint inhibitors, including those targeting CTLA-4/B7 and PD-1/PD-L1 inhibitory pathways, are now available for clinical use on cancer patients. Other interesting checkpoint inhibitors are currently under the development.
ZHA Li, YU Jiaojiao, XU Bin
doaj   +1 more source

Targeting leukemia stem cells in the bone marrow niche [PDF]

, 2018
The bone marrow (BM) niche encompasses multiple cells of mesenchymal and hematopoietic origin and represents a unique microenvironment that is poised to maintain hematopoietic stem cells.
Bertaina, Chen, Emadi, Godwin, Greenberg, Leone, Mohle, Ng, Rettig, Smith, Staudinger, Uy, Vadakekolathu, Vadakekolathu   +13 more
core   +2 more sources

Nicotine Suppresses Phagocytic Ability of Macrophages by Regulating the miR-296-3p–SIRPα Axis

Analytical Cellular Pathology, 2023
Phagocytic ability of macrophage is responsible for tuberculosis infection. Nicotine has been shown to attenuate the phagocytic ability of macrophage; however, the underlying mechanism remains unclear.
Zhen Liu, Fang Wang, Xiaowu Huang, Zhi Chen, Yicheng Zhao, Yawei Wang, Xiaobo Luo, Guanren Zhao   +7 more
doaj   +1 more source

SIRPα modulates the podocyte cytoskeleton through influencing the phosphorylation of FAK at tyrosine residue 597

Acta Biochimica et Biophysica Sinica
Signal regulatory protein α (SIRPα) is recognized as a significant transmembrane protein within the glomeruli that is specifically localized in podocytes, where it plays a role in modulating downstream signaling pathways through phosphorylation.
Xia Yuanyuan, Zhao Yue, Tian Jing, Yang Xue, Fan Yun, Dong Shihui, Yang Fan, Zhang Mingchao, Zeng Caihong   +8 more
doaj   +1 more source

CD47-SIRPα Controls ADCC Killing of Primary T Cells by PMN Through a Combination of Trogocytosis and NADPH Oxidase Activation

Frontiers in Immunology, 2022
Immunotherapies targeting the “don’t eat me” myeloid checkpoint constituted by CD47 SIRPα interaction have promising clinical potential but are limited by toxicities associated with the destruction of non-tumor cells.
Françoise Gondois-Rey, Thomas Miller, Vladimir Laletin, Xavier Morelli, Yves Collette, Jacques Nunès, Daniel Olive   +6 more
doaj   +1 more source

Of macrophages and red blood cells; a complex love story [PDF]

, 2014
Macrophages tightly control the production and clearance of red blood cells (RBC). During steady state hematopoiesis, approximately 10(10) RBC are produced per hour within erythroblastic islands in humans.
Djuna Z. de Back, Elena B. Kostova, Marian van Kraaij, Robin van Bruggen, Timo K. van den Berg   +4 more
core   +2 more sources

Detection of Signal Regulatory Protein α in Saimiri sciureus (Squirrel Monkey) by Anti-Human Monoclonal Antibody

Frontiers in Immunology, 2017
Non-human primates (NHP) are suitable models for studying different aspects of the human system, including pathogenesis and protective immunity to many diseases.
Hugo Amorim dos Santos de Souza, Edmar Henrique Costa-Correa, Cesare Bianco-Junior, Márcia Cristina Ribeiro Andrade, Josué da Costa Lima-Junior, Lilian Rose Pratt-Riccio, Cláudio Tadeu Daniel-Ribeiro, Paulo Renato Rivas Totino   +7 more
doaj   +1 more source

Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy

Nature Communications, 2021
Signal-regulatory protein α (SIRPα) is an inhibitory receptor expressed by myeloid cells. Here the authors show that, in preclinical cancer models, resistance to radiotherapy (RT) observed in wild-type mice is overcome in Sirpα-deficient mice, providing ...
Zhen Bian, Lei Shi, Koby Kidder, Ke Zen, Charlie Garnett-Benson, Yuan Liu   +5 more
doaj   +1 more source

La fusion des macrophages : partenaires des cellules somatiques et cancéreuses ? [PDF]

, 2005
La fusion est un mécanisme fondamental utilisé par les organismes multicellulaires. Elle joue un rôle essentiel au cours du développement physiologique.
Vignery, Agnès
core   +1 more source

Primary phagocytosis of viable neurons by microglia activated with LPS or Aβ is dependent on calreticulin/LRP phagocytic signalling. [PDF]

, 2012
BACKGROUND: Microglia are resident brain macrophages that can phagocytose dead, dying or viable neurons, which may be beneficial or detrimental in inflammatory, ischaemic and neurodegenerative brain pathologies.
Brown, Guy C, Fricker, Michael, Oliva-Martín, María José   +2 more
core   +1 more source