The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloid β toxicity [PDF]
, 2012 BACKGROUND: Phosphatidylserine receptor is a key molecule that mediates the phagocytosis of apoptotic cells. Milk fat globule-EGF factor 8 (MFG-E8) is a phosphatidylserine receptor that is expressed on various macrophage lineage cells, including ...
Akio Suzumura +8 more
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eJHaem, 2023 Signal regulatory protein alpha (SIRPα) is the receptor for cluster of differentiation (CD)47, a potent “don't eat me” signal for macrophages. Disruption of CD47‐SIRPα signaling in the presence of prophagocytic signals can lead to enhanced phagocytosis ...
Mayur Narkhede +10 more
doaj +1 more source
The anatomic distribution and expression of matricellular proteins in the cerebral vasculature of Alzheimer's Disease subjects [PDF]
, 2018 Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder that is characterized by the deterioration of cognitive functioning. AD is the most common form of dementia amongst older adults and currently has no cure.
Lee, Grace
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The role of traction in membrane curvature generation. [PDF]
, 2018 Curvature of biological membranes can be generated by a variety of molecular mechanisms including protein scaffolding, compositional heterogeneity, and cytoskeletal forces.
Alimohamadi, H +4 more
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Transcriptional regulation of DC fate specification [PDF]
, 2020 Dendritic cells function in the immune system to instruct adaptive immune cells to respond accordingly to different threats. While conventional dendritic cells can be subdivided into two main subtypes, termed cDC1s and cDC2s, it is clear that further ...
Bosteels, Cedric, Scott, Charlotte
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Novel process of intrathymic tumor-immune tolerance through CCR2-mediated recruitment of Sirpα+ dendritic cells: a murine model. [PDF]
PLoS ONE, 2012 Immune surveillance system can detect more efficiently secretory tumor-specific antigens, which are superior as a target for cancer immunotherapy. On the contrary, immune tolerance can be induced in the thymus when a tumor antigen is massively secreted ...
Tomohisa Baba +4 more
doaj +1 more source
Immune targets in the tumor microenvironment treated by radiotherapy. [PDF]
, 2019 Radiotherapy (RT), the major anti-cancer modality for more than half of cancer patients after diagnosis, has the advantage of local tumor control with relatively less systematic side effects comparing to chemotherapy.
Li, Jian Jian +2 more
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Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses
Cell ReportsSummary: Signal-regulatory protein alpha (SIRPα) has recently been found to be highly expressed in podocytes and is essential for maintaining podocyte function. However, its immunoregulatory function in podocytes remains elusive.
Bin Qian +10 more
doaj +1 more source
Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides. [PDF]
, 2018 Tissue-specific autoimmunity occurs when selected antigens presented by susceptible alleles of the major histocompatibility complex are recognized by T cells.
Anderson, Mark S +8 more
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Identification and validation of targets for cancer immunotherapy: from the bench-to-bedside [PDF]
, 2013 Chapter 12 in Novel Gene Therapy ...
Brooks, Suzanne E. +4 more
core +3 more sources