Results 81 to 90 of about 10,371 (142)

Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis [PDF]

, 2016
In sarcoidosis, the proinflammatory cytokines interferon gamma, tumour necrosis factor and interleukin-6 are released by monocyte-derived macrophages and lymphocytes in the lungs and other affected tissues. Regulatory receptors expressed on monocytes and
A Crawshaw, AD Vorselaars, AS Bansal, C Prior, CI Daïen, D De Groote, D Hijdra, D Lecossier, DG Walker, DR Moller, GJ Friou, GJ Gibson, GJ Wright, H Fehrenbach, HM Cherwinski, J Baran, J Carlisle, J Unitt, JC Grutters, JP Utz, K Lindahl-Kiessling, K Sahashi, KW Moore, L Landsman, L Ziegler-Heitbrock, M Steffen, MC Jenmalm, MP Chao, O Selroos, P Rottoli, R Gorczynski, RJ Snelgrove, RM Gorczynski, RP Baughman, RP Baughman, S Gao, S Gilbert, SA Eming, SL Kunkel, T Hussell, Y Li   +40 more
core   +2 more sources

Targeting the CD47-SIRPα signaling axis: current studies on B-cell lymphoma immunotherapy

Journal of International Medical Research, 2018
The function of the immune system in cancer initiation and progression has been widely examined. Notably, immunotherapy has become a promising approach for cancer treatment. CD47, a member of the immunoglobulin superfamily, plays an important role in the
Jin Zhang, Shenhe Jin, Xiaojun Guo, Wenbin Qian   +3 more
doaj   +1 more source

Targeting CD47-SIRPα axis for Hodgkin and non-Hodgkin lymphoma immunotherapy

Genes and Diseases
The interaction between cluster of differentiation 47 (CD47) and signal regulatory protein α (SIRPα) protects healthy cells from macrophage attack, which is crucial for maintaining immune homeostasis.
Pengcheng Zhao, Longyan Xie, Lei Yu, Ping Wang   +3 more
doaj   +1 more source

Development of Fully Human Antibodies Targeting SIRPα and PLA2G7 for Cancer Therapy

Antibodies
Background: Macrophages play an important role in eliminating diseased and damaged cells through programmed cell death. Signal regulatory protein alpha (SIRPα) is a crucial immune checkpoint primarily expressed on myeloid cells and macrophages.
Seungmin Shin, Du-San Baek, John W. Mellors, Dimiter S. Dimitrov, Wei Li   +4 more
doaj   +1 more source

Signal regulatory protein α dynamically mediates macrophage polarization facilitated alleviation of ischemic diseases

Cell & Bioscience
Background macrophage-targeting therapy of ischemic disease has made progress in clinic trial. However, the role and underlying mechanism of pro-inflammatory or anti-inflammatory polarized macrophages in modulating ischemic diseases remain incompletely ...
Haiyi Liu, Yonghui Yuan, Takerra K. Johnson-Stephenson, Chenyang Jing, Mingchao Zhang, Jun Huang, Ke Zen, Limin Li, Dihan Zhu   +8 more
doaj   +1 more source

A human antibody specific for SIRPα reprograms macrophages and promotes antibody mediated anti-cancer activity.

PLoS ONE
Several T cell immune checkpoint blockade therapies have shown initial successes in multiple cancers. However, significant issues remain, including tumor relapse, severe toxicities, and a lack of efficacy in most patients.
Keifer G Kurtz, Irina Lebedeva, Stephanie A Pierre, David Andrew, Yu-Rou Liao, Daisy Ambriz, Olivia Vergnolle, Leyi Shen, Elizabeth Nyakatura, Manuel Baca, David A Scheinberg   +10 more
doaj   +1 more source

Silencing of CD47 and SIRPα by Polypurine reverse Hoogsteen hairpins to promote MCF-7 breast cancer cells death by PMA-differentiated THP-1 cells [PDF]

, 2016

core   +1 more source

Turning Erythrocytes into Functional Micromotors [PDF]

, 2014
Attempts to apply artificial nano/micromotors for diverse biomedical applications have inspired a variety of strategies for designing motors with diverse propulsion mechanisms and functions.
Christianson, Caleb, Galarnyk, Michael, Gao, Wei, Gao, Weiwei, He, Qiang, Li, Jinxing, Li, Tianlong, Wang, Joseph, Wu, Zhiguang, Xu, Tailin, Zhang, Liangfang   +10 more
core   +2 more sources

SIRPα modulates microglial efferocytosis and neuroinflammation following experimental subarachnoid hemorrhage via the SHP1/STAT6 axis

Journal of Neuroinflammation
Subarachnoid hemorrhage induces extensive neuronal cell death, leading to the release of damage-associated molecular patterns (DAMPs). These DAMPs, along with hemoglobin and cell corpses, trigger localized inflammation.
Bingtao Zhang, Yan Zou, Qikai Tang, Zixuan Yuan, Kun Jiang, Zhaoxiang Zhang, Shujuan Chen, Qi Wu, Xiaoming Zhou, Xin Zhang   +9 more
doaj   +1 more source

Expression of mouse CD47 on human cancer cells profoundly increases tumor metastasis in murine models [PDF]

, 2015

core   +1 more source