Results 41 to 50 of about 35,822 (223)

miRNAs as Regulators of Antidiabetic Effects of Fucoidans [PDF]

, 2019
open access articleDiabetes mellitus is a metabolic disease with a high mortality rate worldwide. MicroRNAs (miRNAs), and other small noncoding RNAs, serve as endogenous gene regulators through binding to specific sequences in RNA and modifying gene ...
Arroo, R. R. J., El-Seed, Hesham, Ismail, Amin, Lai, Shanshan, Liu, Dan, Wu, Desheng, Xiao, Jianbo, Zhao, Chao, Zou, Xiaobo   +8 more
core   +1 more source

Radioembolization for neuroendocrine tumors: procedure, application and clinical outcomes

Endocrine Oncology
Neuroendocrine liver metastases significantly affect patient prognosis and quality of life due to their symptomatic burden and challenging management. Besides conventional systemic therapies, liver-directed therapies improve patient outcomes in patients ...
Li Shen Ho, Tarik Baetens, Marnix G E H Lam, Arthur J A T Braat   +3 more
doaj   +1 more source

The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver [PDF]

, 2019
Secreted frizzled-related protein (sFRP) 4 is an adipokine with increased expression in white adipose tissue from obese subjects with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).
Al-Hasani, Hadi, Barbosa, David, Fahlbusch, Pia, Herzfeld de Wiza, Daniella, Hörbelt, Tina, Knebel, Birgit, Kotzka, Jorg, Lapauw, Bruno, Müller-Wieland, Dirk, Ouwens, Margriet, Thoresen, G Hege, Van de Velde, Frederique, Van Nieuwenhove, Yves   +12 more
core   +1 more source

Twenty Years of Radiation Therapy of Unresectable Intrahepatic Cholangiocarinoma: Internal or External? A Systematic Review and Meta-Analysis

Liver Cancer, 2021
Purpose: Both external beam radiation therapy (EBRT) and selective-internal radiation therapy (SIRT) are implemented to treat unresectable intrahepatic cholangiocarcinoma (iCCA).
Qian Yu, Chenyu Liu, Anjana Pillai, Osman Ahmed   +3 more
doaj   +1 more source

RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer [PDF]

, 2018
Purpose: Alteration in cell death is a hallmark of cancer. A functional role regulating survival, apoptosis, and necroptosis has been attributed to RIP1/3 complexes.Experimental Design: We have investigated the role of RIP1 and the effects of MC2494 in ...
A. Baldi, A. Chambery, A. Mai, A. Nebbioso, A. Pirolli, D. Rotili, D. Tarantino, E. Radaelli, E.P. Spugnini, F. Cuomo, G. Citro, G. Cobellis, H.G. Stunnenberg, J. Shaik, L. Altucci, L. Maravigna, M. Ruvo, M. Zollo, P. Bontempo, P. Ciana, P. De Antonellis, R. Ragno, R. Russo, V. Carafa   +23 more
core   +2 more sources

Epigenetics and immunometabolism in diabetes and aging [PDF]

, 2018
Significance: A strong relationship between hyperglycemia, impaired insulin pathway and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation.
Cosentino, Francesco, Guzik, Tomasz J.
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Adrenocortical carcinoma: selective internal radiation therapy and liver metastases

Endocrine Oncology
Selective internal radiation therapy (SIRT) is a novel intervention for both primary and metastatic malignant liver lesions. Adrenocortical carcinoma (ACC) is rare with limited treatment options; evidence for SIRT in ACC liver metastases consists of case
Leo Baxendale-Smith, Karim El-Shakankery, James Gordon-Smith, Lucy Wall   +3 more
doaj   +1 more source

Selective Internal Radiation Therapy (SIRT) Versus Sorafenib in Mongolian Patients with Advanced Hepatocellular Carcinoma: A Subgroup Analysis of the SIRveNIB Study

Central Asian Journal of Medical Sciences, 2019
Objective: The purpose of this study was to compare the efficacy and safety of selective internal radiation therapy and sorafenib on advanced hepatocellular carcinoma.
Ariunaa Khasbazar, Sanduijav Rubjir, Baasanjav Nachin, Baatarkhuu Oidov   +3 more
doaj   +1 more source

Telomeres get SIRT-ified [PDF]

Journal of Cell Biology, 2010
![Figure][1] A cell lacking SIRT1 (right) shows increased DNA damage (green) at chromosome ends (red). A protein that protects against aging-related diseases maintains telomere length and integrity, [Palacios et al.][2] reveal. Telomeres protect chromosome ends but grow shorter with age,
openaire   +1 more source