Results 171 to 180 of about 102,380 (310)

Atractylenolide-I Ameliorates Motor Deficits and Reduces Inflammation of the Spinal Cord by SIRT1/PGC-1α Pathway in MPTP Subacute Mouse Model of Parkinson’s Disease

Neuropsychiatric Disease and Treatment
Ya Gao,1 Shuyue Li,1 Jian Zhang,1 Yidan Zhang,1 Yuan Zhao,1 Shuming Zhang,2 Lujie Zuo,3 Guofeng Yang1 1Department of Geriatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of China; 2Department of ...
Gao Y, Li S, Zhang J, Zhang Y, Zhao Y, Zhang S, Zuo L, Yang G   +7 more
doaj  

Metabolome Diversity Enhances Resistance of Intertidal Clams to Thermal Stress

Integrative Zoology, EarlyView.
Meretrix species are widely distributed intertidal bivalves in China with significant ecological and economic importance, which are sensitive to thermal stress. Our results showed that thermal environments of clam habitats shaped metabolome diversity, which can enhance the resistance of intertidal clams to thermal stress.
Zhi Hu, Xiang‐Tao Wei, Xiaonie Lin, Linxuan Ma, Tianzhe Zhang, Yunwei Dong   +5 more
wiley   +1 more source

SIRT1 and microRNA

Frontiers in Physiology, 2012
SIRT1 is an NAD-dependent deacetylase that regulates the cellular response to stressors. SIRT1 is intensively studied as a potental regulator of cellular metabolism and longevity. Pathways of SIRT1 regulation may lead to a greater understanding of metabolism and aging.
openaire   +1 more source

SIRT1 Activators as Geroprotective Agents in Brain Aging: Mechanisms and Therapeutic Potential. [PDF]

Neuromolecular Med
Alameen AAM, Al-Kuraishy HM, Al-Gareeb AI, Alexiou A, Papadakis M, Faheem SA, El-Saber Batiha G.   +6 more
europepmc   +1 more source

Hypothalamic Sirt1 protects terminal Schwann cells and neuromuscular junctions from age‐related morphological changes [PDF]

, 2018
Imai, Shin-ichiro, Jablonka-Shariff, Albina, Santosa, Katherine B, Satoh, Akiko, Snyder-Warwick, Alison K   +4 more
core   +2 more sources

Testicular SIRT1 Loss Reveals an Aging‐Like Proteomic Landscape and Precipitates Reproductive Deterioration

Andrology, EarlyView.
ABSTRACT Background Advanced paternal age is associated with reduced male fertility and testicular dysfunction. Among the molecular regulators involved in aging, SIRT1, a NAD+‐dependent deacetylase, plays a pivotal role in maintaining oxidative balance and cellular homeostasis.
María Iniesta‐Cuerda, Jiřina Havránková, Hedvika Řimnáčová, Jiří Moravec, František Liška, Martin Knytl, Milena Králíčková, Jan Nevoral   +7 more
wiley   +1 more source

SIRT1 in Atherosclerosis: Integrative Control of Vascular Metabolism, Inflammation and Aging. [PDF]

Int J Mol Sci
Chang Y, Li L, Yue H.
europepmc   +1 more source

Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms

British Journal of Pharmacology, EarlyView.
The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all‐cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers.
Lukas Schwingshackl, Jakub Morze, Sabina Wallerer, Georg Hoffmann   +3 more
wiley   +1 more source

Circ‐0030167/IGF2BP1 Induces Mitophagy‐Mediated Ferroptosis via HMOX1 mRNA Stabilization in Pancreatic Cancer

Cancer Science, EarlyView.
Our findings identify circ‐0030167/IGF2BP1/HMOX1 axis as a critical regulatory factor targeting mitochondria‐mediated ferroptosis, thereby presenting a novel therapeutic target for PC combination therapies. ABSTRACT Pancreatic cancer (PC) represents a highly aggressive malignancy characterized by a 5 year survival rate of less than 12%.
Qun Zhao, Xihao Yao, Jingjing Lu, Qiyang Chen, Zhiwei Wang, Xiaohong Li, Yuhua Lu   +6 more
wiley   +1 more source

All the Way: A Decade of SIRT1 in Breast Cancer. [PDF]

Biomedicines
Pratelli G, Montalbano M, Affranchi F, Occhipinti C, Lauricella M, Carlisi D, De Blasio A.   +6 more
europepmc   +1 more source