Results 151 to 160 of about 77,206 (307)

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

NAD-Dependent Protein Deacetylase Sirtuin-1 Mediated Mitophagy Regulates Early Brain Injury After Subarachnoid Hemorrhage

Journal of Inflammation Research
Gen Wang, Ning Lin Department of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University (The First People’s Hospital of Chuzhou), Chuzhou, Anhui Province, People’s Republic of ChinaCorrespondence: Ning Lin, Email lin_neurosurgery@163 ...
Wang G, Lin N
doaj  

Sirtuin1 (sirt1) regulates the glycolysis pathway and decreases cisplatin chemotherapeutic sensitivity to esophageal squamous cell carcinoma

Cancer Biology & Therapy
We aimed to evaluate the influence of sirtuin1 (sirt1) on the ESCC chemotherapeutic sensitivity to cisplatin. We used ESCC cell ablation sirt1 for establishing a xenograft mouse tumor model. The tumor volume was then detected.
Xuewen Yang, Shisen Li, Chunsheng Xu, Shushang Liu, Xiang Zhang, Bo Lian, Mengbin Li   +6 more
doaj   +1 more source

SIRT1 polymorphisms and serum-induced SIRT1 protein expression in aging and frailty: the CHAMP study

, 2017
The nutrient sensing protein, SIRT1 influences aging and nutritional interventions such as caloric restriction in animals, however, the role of SIRT1 in human aging remains unclear. Here, the role of SIRT1 single-nucleotide polymorphisms (SNPs) and serum-
Handelsman, D, Naganathan, V, de Cabo, R, Waite, L, Kennerson, M, Razi, S, Benson, V, Hirani, V, Le Couteur, D, Blyth, F, Seibel, M, McMahon, A, Cogger, V, Cumming, R   +13 more
core   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, EarlyView.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients

, 2017
Chihiro Taka, Ryuji Hayashi, Kazuki Shimokawa, Kotaro Tokui, Seisuke Okazawa, Kenta Kambara, Minehiko Inomata, Toru Yamada, Shoko Matsui, Kazuyuki Tobe First Department of Internal Medicine, Faculty of Medicine, University of Toyama, Sugitani, Toyama ...
Tokui K, Taka C, Yamada T, Shimokawa K, Tobe K, Hayashi R, Kambara K, Inomata M, Matsui S, Okazawa S   +9 more
core  

SIRT1 is a phosphoprotein.

, 2013
A. Affinity-purified SIRT1 is phosphorylated, and can be dephosphorylated by λppase. Top panel, western blot of total SIRT1; middle panel, western blot of SIRT1 phosphorylated at the Cdk consensus site; bottom panel, ProQ-diamond stained blot showing ...
Bernhard Maier (375329), Heidi Scrable (375335), P. Todd Stukenberg (375333), Wendy Gluba (375332), Tsutomu Sasaki (161991), Maksymilian Chruszcz (375331), Katarzyna D. Koclega (375330), Wladek Minor (375334)   +7 more
core   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Sirt1 over-expression in retinal neurons of Nes-Sirt1^OE mice.

, 2014
a) Representative images of retinal cross-section with: (Left) hematoxylin and eosin (H&E) staining showing three retinal neuronal layers: RGC, INL, ONL, and retinal pigment epithelium (RPE)/choroid; and (Right) lectin (red) and DAPI (blue) staining ...
Colman J. Hatton (189068), Meihua Ju (506881), Lucy P. Evans (438235), Zhenghao Cui (438233), Aimee M. Juan (189067), Lois E. H. Smith (102715), Christian G. Hurst (438232), Shaday Michan (272104), Dorothy T. Pei (438234), David A. Sinclair (272113), Jing Chen (4762)   +10 more
core   +1 more source