Results 131 to 140 of about 72,220 (305)

Resveratrol Ameliorates Allergic Rhinitis by Activating SIRT1 to Disrupt the Mitochondrial ROS‐Inflammation Vicious Cycle

Flavour and Fragrance Journal, EarlyView.
This study demonstrates that resveratrol alleviates allergic rhinitis by activating SIRT1, thereby disrupting the mitochondrial ROS‐inflammatory cycle, improving mitochondrial function, promoting anti‐inflammatory M2 macrophage polarisation, and reducing epithelial oxidative damage.
Xinyu Zhou, Yi Yue, Wenwen Qi, Wenqing Zhu, Xinran Liu, Rongcui Sui, Xuanchen Zhou   +6 more
wiley   +1 more source

Sirtuins, bioageing, and cancer [PDF]

, 2011
The Sirtuins are a family of orthologues of yeast Sir2 found in a wide range of organisms from bacteria to man. They display a high degree of conservation between species, in both sequence and function, indicative of their key biochemical roles. Sirtuins
P. G. Shiels, McGuinness, D., McCaul, J., J. A. McCaul, Shiels, P.G., McGuinness, D.H., D. McGuinness, D. H. McGuinness   +7 more
core   +1 more source

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients [PDF]

, 2017
Chihiro Taka, Ryuji Hayashi, Kazuki Shimokawa, Kotaro Tokui, Seisuke Okazawa, Kenta Kambara, Minehiko Inomata, Toru Yamada, Shoko Matsui, Kazuyuki Tobe First Department of Internal Medicine, Faculty of Medicine, University of Toyama, Sugitani, Toyama ...
Tokui K, Taka C, Yamada T, Shimokawa K, Tobe K, Hayashi R, Kambara K, Inomata M, Matsui S, Okazawa S   +9 more
core  

SIRT1 polymorphisms and serum-induced SIRT1 protein expression in aging and frailty: the CHAMP study [PDF]

, 2017
The nutrient sensing protein, SIRT1 influences aging and nutritional interventions such as caloric restriction in animals, however, the role of SIRT1 in human aging remains unclear. Here, the role of SIRT1 single-nucleotide polymorphisms (SNPs) and serum-
Handelsman, D, Naganathan, V, de Cabo, R, Waite, L, Kennerson, M, Razi, S, Benson, V, Hirani, V, Le Couteur, D, Blyth, F, Seibel, M, McMahon, A, Cogger, V, Cumming, R   +13 more
core   +1 more source

Endothelial senescence and microRNA

Biomolecular Concepts, 2012
Cellular senescence occurs when cells lose the ability to divide and proliferate. Endothelial cell senescence is associated with vascular diseases, such as atherosclerosis. In this review, I discuss the factors affecting endothelial cell senescence. Then
Yamakuchi Munekazu
doaj   +1 more source

SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex [PDF]

, 2013
SirT1 is a class III histone deacetylase that has been implicated in metabolic and reactive oxygen species control. In the vasculature it has been shown to decrease endothelial superoxide production, prevent endothelial dysfunction and atherosclerosis ...
Cabezudo, Sofía, Olmos Buchelt, Yolanda, Lamas, Santiago, Wild, Brigitte, García Quintans, Nieves, Sánchez Gómez, Francisco J., Monsalve, María   +6 more
core   +1 more source

Roux-en-Y Gastric Bypass Improves Hepatic Glucose Metabolism Involving Upregulation of Sirt1 in Type 2 Diabetes Mellitus

Diabetes, Metabolic Syndrome and Obesity, 2021
Chunjie Su,1 Qian Cheng,2 Liyun Wang2 1Department of Gastrointestinal Surgery, Jingmen No.1 People’s Hospital, Jingmen, 448000, People’s Republic of China; 2Department of Endocrinology, Yixing People’s Hospital, Yixing, 214200, Jiangsu,
Su C, Cheng Q, Wang L
doaj  

Origin of Monocytes/Macrophages Contributing to Chronic Inflammation in Chagas Disease: SIRT1 Inhibition of FAK-NFκB-Dependent Proliferation and Proinflammatory Activation of Macrophages

Cells, 2019
Background: Trypanosoma cruzi (Tc) causes Chagas disease (CD) that is the most frequent cause of heart failure in Latin America. TNF-α+ monocytes/macrophages (Mo/Mφ) are associated with inflammatory pathology in chronic CD.
Xianxiu Wan, Imran Hussain Chowdhury, Zuliang Jie, Subhadip Choudhuri, Nisha Jain Garg   +4 more
doaj   +1 more source