Results 121 to 130 of about 72,220 (305)
The Role of Nicotinamide in Cancer Chemoprevention and Therapy
Biomolecules, 2020 Nicotinamide (NAM) is a water-soluble form of Vitamin B3 (niacin) and a precursor of nicotinamide-adenine dinucleotide (NAD+) which regulates cellular energy metabolism.
Ilias P. Nikas +2 more
doaj +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
结直肠肛门外科[Objectives] To preliminarily investigate the mechanism of Buzhong Yiqi decoction in inhibiting endothelial cell pyroptosis via SIRT1. [Methods] A hemorrhoid model was established in SD rats by topical application of glacial acetic acid. Thirty rats were
Xiao Kaihua +4 more
doaj +1 more source
Effect of H2S on the circadian rhythm of mouse hepatocytes
Lipids in Health and Disease, 2012 Background Dysregulation of circadian rhythms can contribute to diseases of lipid metabolism. NAD-dependent deacetylase sirtuin-1(SIRT1) is an important hub which links lipid metabolism with circadian clock by its deacetylation activity depends on ...
Shang Zhanxian +4 more
doaj +1 more source
The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle
ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley +1 more source
Effect of SIRT1 or SIRT1 (H363Y) overexpression on acetylation of p53 in C2C12 myoblasts. [PDF]
, 2015 (A) Protein expression of SIRT1 or SIRT1 (H363Y) in C2C12 myoblasts; (B) acetyl-p53 (K376) in C2C12 myoblasts overexpressing empty vector, SIRT1 or SIRT1 (H363Y ...
Gregory J. Cooney (183923) +9 more
core +1 more source
Artificial Chlorella Biohybrids for Alleviation of Cartilage Degeneration in Osteoarthritis
Exploration, EarlyView.Artificial Chlorella biohybrids (Ch@P) alleviate cartilage degeneration and protect against OA progression by activating mitophagy and reprogramming glucose metabolism in chondrocytes, as well as inducing articular thermal stimulation under near infrared irradiation.
Yongyun Chang +19 more
wiley +1 more source
A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation
Food Chemistry International, EarlyView.Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee +4 more
wiley +1 more source
SirT1 Regulates Adipose Tissue Inflammation [PDF]
, 2011 OBJECTIVE Macrophage recruitment to adipose tissue is a reproducible feature of obesity. However, the events that result in chemokine production and macrophage recruitment to adipose tissue during states of energetic ...
David W. Frederick +33 more
core +1 more source
Research in Pharmaceutical SciencesBackground and purpose: Renal injury is a serious disorder that can be caused by some diseases or agents. Rosmarinic acid (RA) is a natural and safe compound with powerful antioxidant and anti-inflammatory properties.
Maryam Mottaghi +4 more
doaj +1 more source