Results 121 to 130 of about 77,206 (307)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

Endothelial senescence and microRNA

Biomolecular Concepts, 2012
Cellular senescence occurs when cells lose the ability to divide and proliferate. Endothelial cell senescence is associated with vascular diseases, such as atherosclerosis. In this review, I discuss the factors affecting endothelial cell senescence. Then
Yamakuchi Munekazu
doaj   +1 more source

SIRT1 destabilizes WRN protein.

, 2013
A, Flag-WRN alone or with SIRT1 was transfected into HEK293 cells. Cell lysates were subjected to SDS-PAGE and Western blotting with anti-WRN, anti-SIRT1 and anti-β-Actin antibodies. B, endogenous WRN protein level was decreased by SIRT1. Vector or SIRT1
Rui Wang (52434), Wei Fan (109074), Jianyuan Luo (365405), Enerlyn Lozada (365402), David K. Orren (365403), Kai Li (205203)   +5 more
core   +1 more source

Sirtuins, bioageing, and cancer [PDF]

, 2011
The Sirtuins are a family of orthologues of yeast Sir2 found in a wide range of organisms from bacteria to man. They display a high degree of conservation between species, in both sequence and function, indicative of their key biochemical roles. Sirtuins
P. G. Shiels, McGuinness, D., McCaul, J., J. A. McCaul, Shiels, P.G., McGuinness, D.H., D. McGuinness, D. H. McGuinness   +7 more
core   +1 more source

A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation

Food Chemistry International, EarlyView.
Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee, Tien‐Fen Kuo, Chun‐Yen Yang, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

Roux-en-Y Gastric Bypass Improves Hepatic Glucose Metabolism Involving Upregulation of Sirt1 in Type 2 Diabetes Mellitus

Diabetes, Metabolic Syndrome and Obesity, 2021
Chunjie Su,1 Qian Cheng,2 Liyun Wang2 1Department of Gastrointestinal Surgery, Jingmen No.1 People’s Hospital, Jingmen, 448000, People’s Republic of China; 2Department of Endocrinology, Yixing People’s Hospital, Yixing, 214200, Jiangsu,
Su C, Cheng Q, Wang L
doaj  

Origin of Monocytes/Macrophages Contributing to Chronic Inflammation in Chagas Disease: SIRT1 Inhibition of FAK-NFκB-Dependent Proliferation and Proinflammatory Activation of Macrophages

Cells, 2019
Background: Trypanosoma cruzi (Tc) causes Chagas disease (CD) that is the most frequent cause of heart failure in Latin America. TNF-α+ monocytes/macrophages (Mo/Mφ) are associated with inflammatory pathology in chronic CD.
Xianxiu Wan, Imran Hussain Chowdhury, Zuliang Jie, Subhadip Choudhuri, Nisha Jain Garg   +4 more
doaj   +1 more source

Rev1 contributes to proper mitochondrial function via the PARP-NAD⁺-SIRT1-PGC1α axis

, 2017
Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α ...
LJ Rasmussen (14451144), A Tsaalbi-Shtylik (13342089), MH Olive (15837476), N De Wind (13342128), VA Bohr (15837479), C Desler (13341873), K Thomsen (13342140), JA Durhuus (15837443), NB Fakouri (15837470), M Angleys (13342134), CE Regnell (15837473), LH Bergersen (15837482), A Martín-Pardillos (13342086), M Lauritzen (13342143)   +13 more
core  

Nutrition and Metabolic Diseases: A Systematic Review of Functional Foods, Medicinal Plants, Phytochemicals, Bioactive Compounds and Nutrients Effective Against Metabolic Diseases

Food Chemistry International, EarlyView.
The study demonstrates how functional foods, medicinal plants, phytochemicals, bioactive compounds and essential nutrients combat metabolic diseases. It highlights their mechanisms, including antioxidant, anti‐inflammatory, insulin‐sensitising, lipid‐regulating, gut microbiota‐modulating and mitochondrial‐enhancing effects, leading to improved ...
Chinaza Godswill Awuchi, Sana Noreen, Sonia Morya   +2 more
wiley   +1 more source