Results 101 to 110 of about 72,220 (305)
miR-138 Increases Depressive-Like Behaviors by Targeting SIRT1 in Hippocampus
Neuropsychiatric Disease and Treatment, 2020 Cuixia Li,1 Feng Wang,2 Pei Miao,1 Libo Yan,1 Silin Liu,1 Xian Wang,1 Zuolin Jin,1 Zexu Gu1 1State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases ...
Li C +7 more
doaj
SIRT1 and other sirtuins in metabolism [PDF]
Trends in Endocrinology & Metabolism, 2014 Sirtuins such as SIRT1 are conserved protein NAD(+)-dependent deacylases and thus their function is intrinsically linked to cellular metabolism. Over the past two decades, accumulating evidence has indicated that sirtuins are not only important energy status sensors but also protect cells against metabolic stresses.
Chang, Hung-Chun +1 more
openaire +4 more sources
Advanced Science, EarlyView.A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao +11 more
wiley +1 more source
SIRT1 destabilizes WRN protein. [PDF]
, 2013 A, Flag-WRN alone or with SIRT1 was transfected into HEK293 cells. Cell lysates were subjected to SDS-PAGE and Western blotting with anti-WRN, anti-SIRT1 and anti-β-Actin antibodies. B, endogenous WRN protein level was decreased by SIRT1. Vector or SIRT1
Rui Wang (52434) +5 more
core +1 more source
Advanced Science, EarlyView.In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang +6 more
wiley +1 more source
SIRT1 gene polymorphisms and risk of lung cancer [PDF]
, 2017 Yanbo Lv, Shuangyan Lin, Fang Peng Department of Pathology, Zhejiang Hospital, Hangzhou City, Zhejiang, China Objective: Lung cancer, which is the leading cause of cancer death worldwide, is influenced by a wide variety of environmental and ...
Peng F, Lv Y, Lin SY
core
Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia
Advanced Science, EarlyView.Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li +8 more
wiley +1 more source
Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise [PDF]
, 2012 Cameron B Williams, Brendon J GurdSchool of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, CanadaAbstract: Silent mating type information regulation 2 homolog 1 (SIRT1) is implicated in the control of skeletal muscle ...
Williams CB, Gurd BJ
core
Phosphorylation regulates SIRT1 function. [PDF]
, 2008 BackgroundSIR2 is an NAD(+)-dependent deacetylase [1]-[3] implicated in the regulation of lifespan in species as diverse as yeast [4], worms [5], and flies [6].
Heidi Scrable +15 more
core +1 more source
OncoImmunology, 2018 High-grade gliomas are malignant aggressive primary brain tumors with limited therapeutic options, and dismal prognosis for patients. Microglia, the resident immune cells of the brain, are recruited and reprogrammed into tumor-supporting cells by glioma ...
Dalel Saidi +7 more
doaj +1 more source