Results 91 to 100 of about 77,206 (307)

Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases

, 2020
Neurodegenerative disease refers to a range of chronic and progressive disorders that are characterized by dysfunction and loss of neurons. Neurodegeneration involves protein misfolding, oxidative injury, impaired mitochondrial function, neurotrophin ...
Zhang, Yuqing, Anoopkumar-Dukie, Shailendra, Arora, Devinder, Davey, Andrew K   +3 more
core   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

LINC00987 Ameliorates COPD by Regulating LPS-Induced Cell Apoptosis, Oxidative Stress, Inflammation and Autophagy Through Let-7b-5p/SIRT1 Axis

International Journal of COPD, 2020
Yuanyuan Wang,1 Jingjing Chen,1 Wei Chen,2 Ling Liu,2 Mei Dong,2 Juan Ji,2 Die Hu,3 Nianzhi Zhang2 1Graduate School, Anhui University of Chinese Medicine, Anhui, Hefei 230012, People’s Republic of China; 2Department of Respiratory Medicine, The ...
Wang Y, Chen J, Chen W, Liu L, Dong M, Ji J, Hu D, Zhang N   +7 more
doaj  

Curcumin Protects Against Myocardial Infarction-Induced Cardiac Fibrosis via SIRT1 Activation in vivo and in vitro [Corrigendum]

Drug Design, Development and Therapy, 2022
Xiao J, Sheng X, Zhang X, Guo M, Ji X. Drug Des Devel Ther. 2016;10:1267–1277. The authors have advised due to an error at the time of figure assembly, Figure 5A on page 1274 is incorrect. The correct Figure 5 is shown in Download Article.
Xiao J, Sheng X, Zhang X, Guo M, Ji X
doaj  

SIRT1-mediated CRIF1 deletion-induced inflammatory cytokine and VCAM-1 expression.

, 2018
(A) HUVECs were infected with β-Gal and SIRT1 adenovirus for 24 h, followed by transfection with CRIF1 (100 pmol) siRNA for 36 h. TNFα, IL-1β, and IL-6 mRNA levels were quantified using qPCR.
Byeong Hwa Jeon (573935), Ikjun Lee (4731330), Sung-min Kim (4731339), Saet-byel Jung (4731324), Kaikobad Irani (346311), Nara Shin (173813), Cuk-Seong Kim (417673), Jin Bong Park (4731321), Minho Won (92897), Shuyu Piao (4731327), Jun Wan Lee (4731333), Harsha Nagar (573931), Sujeong Choi (4731342), Gang Min Hur (92907), Dong Woon Kim (3138504), Yu Ran Lee (4731318), Seonhee Kim (4731336), Sang Do Lee (91685)   +17 more
core   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

miR-138 Increases Depressive-Like Behaviors by Targeting SIRT1 in Hippocampus

Neuropsychiatric Disease and Treatment, 2020
Cuixia Li,1 Feng Wang,2 Pei Miao,1 Libo Yan,1 Silin Liu,1 Xian Wang,1 Zuolin Jin,1 Zexu Gu1 1State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases ...
Li C, Wang F, Miao P, Yan L, Liu S, Wang X, Jin Z, Gu Z   +7 more
doaj  

SIRT1 and energy metabolism [PDF]

Acta Biochimica et Biophysica Sinica, 2013
Sirtuin 1 (SIRT1) is the most conserved mammalian NAD(+)-dependent protein deacetylase that has emerged as a key metabolic sensor in various metabolic tissues. In response to different environmental stimuli, SIRT1 directly links the cellular metabolic status to the chromatin structure and the regulation of gene expression, thereby modulating a variety ...
openaire   +2 more sources

Active Regulator of SIRT1 Cooperates with SIRT1 and Facilitates Suppression of p53 Activity [PDF]

Molecular Cell, 2007
Human SIRT1 is an NAD+-dependent deacetylase protein that plays a role in cell death/survival, senescence, and endocrine signaling. While its substrates, including p53, have been well characterized, no direct regulators are known. We describe here a nuclear protein, active regulator of SIRT1 (AROS), which directly regulates SIRT1 function.
Kim, Eun-Joo, Kho, Jeong-Hoon, Kang, Moo-Rim, Um, Soo-Jong   +3 more
openaire   +3 more sources

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source