Results 91 to 100 of about 102,380 (310)

Circadian clocks and breast cancer [PDF]

, 2016
Circadian clocks respond to environmental time cues to coordinate 24-hour oscillations in almost every tissue of the body. In the breast, circadian clocks regulate the rhythmic expression of numerous genes.
Blakeman, V, Meng, Q-J, Streuli, CH, Williams, JL   +3 more
core   +2 more sources

SIRT1 and energy metabolism [PDF]

Acta Biochimica et Biophysica Sinica, 2013
Sirtuin 1 (SIRT1) is the most conserved mammalian NAD(+)-dependent protein deacetylase that has emerged as a key metabolic sensor in various metabolic tissues. In response to different environmental stimuli, SIRT1 directly links the cellular metabolic status to the chromatin structure and the regulation of gene expression, thereby modulating a variety ...
openaire   +2 more sources

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

Advanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
wiley   +1 more source

LINC00987 Ameliorates COPD by Regulating LPS-Induced Cell Apoptosis, Oxidative Stress, Inflammation and Autophagy Through Let-7b-5p/SIRT1 Axis

International Journal of COPD, 2020
Yuanyuan Wang,1 Jingjing Chen,1 Wei Chen,2 Ling Liu,2 Mei Dong,2 Juan Ji,2 Die Hu,3 Nianzhi Zhang2 1Graduate School, Anhui University of Chinese Medicine, Anhui, Hefei 230012, People’s Republic of China; 2Department of Respiratory Medicine, The ...
Wang Y, Chen J, Chen W, Liu L, Dong M, Ji J, Hu D, Zhang N   +7 more
doaj  

Transient-mediated fate determination in a transcriptional circuit of HIV [PDF]

, 2007
Steady-state behavior and bistability have been proposed as mechanisms for decision-making in gene circuits. However, transient gene expression has also been proposed to control cell fate with the decision arbitrated by the lifetime of the expression ...
Leor Weinberger, Michael Simpson, Roy D. Dar   +2 more
core   +1 more source

Utilizing small nutrient compounds as enhancers of exercise-induced mitochondrial biogenesis. [PDF]

, 2015
Endurance exercise, when performed regularly as part of a training program, leads to increases in whole-body and skeletal muscle-specific oxidative capacity.
Acheson, Achten, Alemo Munters, Alexander, Andersen, Atherton, Baar, Baggish, Bartlett, Bartlett, Bassett, Beere, Bonen, Bonne, Boon, Bosselaar, Bravo, Bruckbauer, Buijsse, Cantó, Carey, Chen, Chong, Coggan, Crowe, Crowe, Cureton, Cuthbertson, D'Antona, Davis, Davis, Dominy, Dorta, Dulloo, Dulloo, Dumke, Egawa, Egawa, Eid, Fan, Ferketich, Fitts, Ganio, Gibala, Gliemann, Gollnick, Goodyear, Graham, Green, Gualano, Gutiérrez-Salmeán, Hagberg, Harms, Hasler, Hawley, Hawley, Hodgson, Holloszy, Holloszy, Holloszy, Hoppeler, Howitz, Hüttemann, Ingjer, Ivy, Jones, Jung, Kalliokoski, Karlsson, Klausen, Koivisto, Labayen, Lee, Liang, Lin, Little, Lluís, López-Lluch, MacMahon, Martínez-Redondo, Matsakas, Maughan, Merrill, Molé, Montero, Moore, Moore, Morris, Murase, Murase, Murias, Murias, Narkar, Nieman, Nogueira, Olesen, Oscai, Ota, Park, Perez-Schindler, Philp, Pogozelski, Puigserver, Putman, Raben, Randell, Randell, Richter, Sahebkar, Saleem, Saltin, Saltin, Saltin, Saltin, Sawka, Scribbans, Shimotoyodome, Siemann, Simoneau, Smith, Spangenburg, Spina, Spina, Steinberg, Suchankova, Sun, Venables, Wang, White, Winder, Wright, Wright, Yan, Youn, Zhu   +134 more
core   +5 more sources

PRMT5/Sohlh2/Sirt1 Signaling Pathway in Vascular Endothelial Cells Modulates Lung Metastasis of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The cover image shows that vascular endothelial cells play an important role in lung metastasis of TNBC. Endothelial Sohlh2 acts as a gatekeeper against TNBC lung metastasis by limiting endothelial activation and tumor cell passage. PRMT5 reduces Sohlh2 stability, weakening this protective barrier.
Ruihong Zhang, Fengqin Wang, Lanlan Liu, Qi Zhang, Xiaoning Huo, Yanhui Nan, Yanli Dong, Yunling Xiao, Jing Hao   +8 more
wiley   +1 more source

miR-138 Increases Depressive-Like Behaviors by Targeting SIRT1 in Hippocampus

Neuropsychiatric Disease and Treatment, 2020
Cuixia Li,1 Feng Wang,2 Pei Miao,1 Libo Yan,1 Silin Liu,1 Xian Wang,1 Zuolin Jin,1 Zexu Gu1 1State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases ...
Li C, Wang F, Miao P, Yan L, Liu S, Wang X, Jin Z, Gu Z   +7 more
doaj  

Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis [PDF]

, 2016
Funding The study was funded entirely by institutional funds.Peer ...
Galley, H. F., Lowes, D. A., McCreath, G., Scullion, M. M. F., Webster, N. R.   +4 more
core   +1 more source

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Advanced Science, EarlyView.
Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan, Yelian Yan, Yalin Liang, Kanghua Zhong, Zhican Fu, Xiaobo Wang, Chao Liu, Tao Huang, Keliang Wu   +8 more
wiley   +1 more source