Results 91 to 100 of about 72,220 (305)
SIRT1-mediated acute cardioprotection [PDF]
, 2011 Overexpression studies have revealed a role for silent information regulator of transcription 1 (SIRT1) lysine deacetylase in cardioprotection against ischemia-reperfusion injury via long-term transcriptional effects.
Michael W. McBurney +6 more
core +1 more source
Aging, 2014 There is an old Japanese proverb saying, “After rain falls, the ground hardens.” This proverb illustrates what has happened to the research field on the importance of sirtuins in the regulation of aging and longevity. The Sir2 (silent information regulator 2) family of protein deacylases, now called sirtuins, have been shown to regulate aging and ...
Akiko, Satoh, Shin-ichiro, Imai
openaire +2 more sources
Advanced Science, EarlyView.This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao +13 more
wiley +1 more source
Sirt1 and cell migration [PDF]
Cell Adhesion & Migration, 2010 Sirt1 is a type III histone deacetylase implicated in a wide range of physiological and pathophysiological roles. Acting though a myriad of non-histone substrates, Sirt1 modulates transcriptional regulation of energy metabolism and stress response, with important consequences on cell survival and a myriad of human pathologies.
openaire +2 more sources
Advanced Science, EarlyView.Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang +10 more
wiley +1 more source
International Journal of COPD, 2020 Yuanyuan Wang,1 Jingjing Chen,1 Wei Chen,2 Ling Liu,2 Mei Dong,2 Juan Ji,2 Die Hu,3 Nianzhi Zhang2 1Graduate School, Anhui University of Chinese Medicine, Anhui, Hefei 230012, People’s Republic of China; 2Department of Respiratory Medicine, The ...
Wang Y +7 more
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Drug Design, Development and Therapy, 2022 Xiao J, Sheng X, Zhang X, Guo M, Ji X. Drug Des Devel Ther. 2016;10:1267–1277. The authors have advised due to an error at the time of figure assembly, Figure 5A on page 1274 is incorrect. The correct Figure 5 is shown in Download Article.
Xiao J, Sheng X, Zhang X, Guo M, Ji X
doaj
The skinny on SIRT1 regulation [PDF]
Disease Models & Mechanisms, 2010 SIRT1 (sirtuin 1), the mammalian orthologue of yeast Sir2, is a highly conserved NAD+-dependant deacetylase that is emerging as an important regulator of aging and metabolic disease. SIRT1 and its family members promote longevity in different model organisms, including yeast, worms, flies and mice.
openaire +2 more sources
Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration
Advanced Science, EarlyView.This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya +10 more
wiley +1 more source
Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis [PDF]
, 2017 Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α ...
LJ Rasmussen (14451144) +13 more
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