Results 111 to 120 of about 72,220 (305)

SIRT1, resveratrol and aging

Frontiers in Genetics
Aging is linked to a time-associated decline in both cellular function and repair capacity leading to malfunction on an organismal level, increased frailty, higher incidence of diseases, and death. As the population grows older, there is a need to reveal mechanisms associated with aging that could spearhead treatments to postpone the onset of age ...
Blanka Rogina, Blanka Rogina, Heidi A. Tissenbaum   +2 more
openaire   +3 more sources

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Inhibition of SIRT1 combined with gemcitabine therapy for pancreatic carcinoma [PDF]

, 2013
Dao-Jun Gong,1 Jia-Min Zhang,1 Min Yu,1 Bo Zhuang,1 Qing-Qu Guo21Department of Hepatobiliary-Pancreatic Surgery, Jinhua Hospital of Zhejiang University, Jinhua, People's Republic of China; 2Department of Surgery, Second Affiliated Hospital of ...
Zhang JM, Yu M, Gong DJ, Guo QQ, Zhuang B   +4 more
core  

PCGT DNA methylation by SIRT1 [PDF]

, 2014
Genes that lost DNA methylation with SIRT1 knockdown and/or gained DNA methylation with SIRT1 overexpression (positive DNA methylation response to SIRT1) and genes that responded to SIRT1 in an opposite direction (negative response to SIRT1) in Caco-2 ...
Dianne Ford (616989)
core   +1 more source

SIRT1 and energy metabolism [PDF]

Acta Biochimica et Biophysica Sinica, 2013
Sirtuin 1 (SIRT1) is the most conserved mammalian NAD(+)-dependent protein deacetylase that has emerged as a key metabolic sensor in various metabolic tissues. In response to different environmental stimuli, SIRT1 directly links the cellular metabolic status to the chromatin structure and the regulation of gene expression, thereby modulating a variety ...
openaire   +2 more sources

Dietary Glutamine Supplementation Alleviated Rumen Epithelium Oxidative Damage and Apoptosis Induced by Feed Restriction via Maintaining Mitochondrial Homeostasis in Female Yaks

Animal Research and One Health, EarlyView.
Dietary glutamine (Gln) supplementation increased the ATP levels and promoted cell proliferation in the rumen epithelium of feed‐restricted yaks. Besides, Gln inhibited ROS accumulation and reduced oxidative damage and apoptosis in the rumen epithelium of feed‐restricted yaks.
Ziqi Yue, Shanpeng Ke, Liyuan Shi, Rui Hu, Zhisheng Wang, Quanhui Peng, Huawei Zou, Jianxin Xiao, Yahui Jiang, Fali Wu, Yiping Tang   +10 more
wiley   +1 more source

Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo [PDF]

, 2013
Sirtuins (SIRT1-7) are a highly conserved family of NAD(+)-dependent enzymes that control the activity of histone and nonhistone regulatory proteins. SIRT1 is purposed to promote longevity and to suppress the initiation of some cancers.
Candinas, Daniel, Lämmle, Alexander, Overney, Sarah, Lechleiter, Antje, Tschan, Mario, Mikami, Kei, Keogh, Adrian, Portmann, Simone, Fahrner, René, Montani, Matteo, Keogh-Stroka, Deborah M.   +10 more
core   +1 more source

Investigating the Combined Effect of Aerobic Training with Resveratrol Resveratrol Consumption on SIRT1 and PGC-1α Levels in Gastrocnemius Muscle of Rats after Spinal Cord Injury [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Atrophy of the skeletal system caused by spinal cord injury (SCI) can cause secondary systemic metabolic dysfunction, such as glucose intolerance, type 2 diabetes, and insulin resistance.
Eskandar Garmei, Ali Yaghoubi, Najmeh Rezaeian   +2 more
doaj  

An all‐in‐one fucosylated gold nanocluster probe enables NIR‐II imaging and multi‐mechanistic therapy of acute kidney injury

BMEMat, EarlyView.
This study developed a fucoside‐targeted gold nanocluster probe that enables early NIR‐II imaging and multi‐mechanistic therapy for acute kidney injury, effectively mitigating oxidative stress, modulating inflammatory responses, and inhibiting ferroptosis to improve renal outcomes. Abstract Acute kidney injury (AKI) remains a life‐threatening condition
Ping Zhang, Boning Tan, Suqing Feng, Beibei Gu, Ting Feng, Haiguang Zhu, Jianping Xie, Xun Yuan   +7 more
wiley   +1 more source

Remimazolam Combined with Andrographolide Improve Postoperative Cognitive Dysfunction in Rats after Cardiopulmonary Bypass through the AMPK/SIRT1 Signaling Pathway

Journal of Integrative Neuroscience
Introduction: The effects of remimazolam (Re) in combination with andrographolide (AP) on learning, memory, and motor abilities in rats following cardiopulmonary bypass (CPB) surgery were studied.
Chong Chen, Lixia Lan, Kai Xu
doaj   +1 more source