Results 141 to 150 of about 72,220 (305)

The role of SIRT1 in diabetic retinopathy

Biomedicine & Pharmacotherapy, 2018
The prevalence of diabetes mellitus (DM), has been increasing worldwide. Diabetic retinopathy (DR) is the most common microvascular complication in diabetes. It is a multifactorial disease that occurs primarily through the long-term detrimental effects of hyperglycemia.
Hedyieh, Karbasforooshan, Gholamreza, Karimi   +1 more
openaire   +2 more sources

JNK2-dependent regulation of SIRT1 protein stability [PDF]

, 2008
Mammalian SIRT1 is an NAD-dependent deacetylase with critical roles in the maintenance of homeostasis and cell survival. Elevated levels of SIRT1 protein are evident in cancer in which SIRT1 can function as a cancer-specific survival factor.
Ahmed, Shafiq U., Jack Ford, Simon Allison, Shafiq Ahmed, Jo Milner, Ming Jiang, Allison, Simon J., Jiang, Ming, Milner, Jo, Ford, Jack   +9 more
core   +1 more source

Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes

Romanian Journal of Internal Medicine, 2019
Introduction. Liraglutide (L) is the analogue of human glucagon-like peptide 1 which stimulates glucose-dependent insulin secretion and can modify the level of inflammatory biomarkers.
Savchenko Liudmyla G., Digtiar Nataliia I., Selikhova Liudmyla G., Kaidasheva Elvira I., Shlykova Oksana A., Vesnina Liudmyla E., Kaidashev Igor P.   +6 more
doaj   +1 more source

Sirt1 over-expression in retinal neurons of Nes-Sirt1^OE mice. [PDF]

, 2014
a) Representative images of retinal cross-section with: (Left) hematoxylin and eosin (H&E) staining showing three retinal neuronal layers: RGC, INL, ONL, and retinal pigment epithelium (RPE)/choroid; and (Right) lectin (red) and DAPI (blue) staining ...
Colman J. Hatton (189068), Meihua Ju (506881), Lucy P. Evans (438235), Zhenghao Cui (438233), Aimee M. Juan (189067), Lois E. H. Smith (102715), Christian G. Hurst (438232), Shaday Michan (272104), Dorothy T. Pei (438234), David A. Sinclair (272113), Jing Chen (4762)   +10 more
core   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

iMetaOmics, EarlyView.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li, Shuai Liu, Zhijun Cao, Yangchun Cao, Shengru Wu, Lu Deng, Junhu Yao, Jun Zhang   +7 more
wiley   +1 more source

SIRT1 is a phosphoprotein. [PDF]

, 2013
A. Affinity-purified SIRT1 is phosphorylated, and can be dephosphorylated by λppase. Top panel, western blot of total SIRT1; middle panel, western blot of SIRT1 phosphorylated at the Cdk consensus site; bottom panel, ProQ-diamond stained blot showing ...
Bernhard Maier (375329), Heidi Scrable (375335), P. Todd Stukenberg (375333), Wendy Gluba (375332), Tsutomu Sasaki (161991), Maksymilian Chruszcz (375331), Katarzyna D. Koclega (375330), Wladek Minor (375334)   +7 more
core   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source