Results 141 to 150 of about 77,206 (307)

PCGT DNA methylation by SIRT1

, 2014
Genes that lost DNA methylation with SIRT1 knockdown and/or gained DNA methylation with SIRT1 overexpression (positive DNA methylation response to SIRT1) and genes that responded to SIRT1 in an opposite direction (negative response to SIRT1) in Caco-2 ...
Dianne Ford (616989)
core   +1 more source

Cross‐Regulation Between DNA Methylation and Circadian Clock Reprogramming in Ovarian Cancer: Mechanistic Insights, Biomarker Potential, and Therapeutic Implications

International Journal of Cancer, EarlyView.
ABSTRACT Early diagnosis remains challenging, recurrence rates remain high, and platinum resistance frequently develops in ovarian cancer (OC), collectively representing major barriers to long‐term patient survival. DNA methylation (DNAm), as a relatively stable yet dynamically modifiable epigenetic signature, can capture alterations in tumor states ...
Min Xing, Chang Zhou, Yi Tang, Shuhui Xu, Shasha Zhou, Weiai Liu, Huiping Liu   +6 more
wiley   +1 more source

SirT1 Regulates Adipose Tissue Inflammation

, 2011
OBJECTIVE Macrophage recruitment to adipose tissue is a reproducible feature of obesity. However, the events that result in chemokine production and macrophage recruitment to adipose tissue during states of energetic ...
David W. Frederick, Derek M. Erion, Kevin T. Nead, Gerald I. Shulman, Gillum, Matthew P., Romy Kursawe, Qiang, Li, Olefsky, Jerrold M., Chatterjee, Paula, Yonemitsu, Shin, Hsiao, Jennifer J., Jennifer J. Hsiao, Alexander S. Banks, Muise, Eric S., Sanjay Bhanot, Li Qiang, Kursawe, Romy, Nead, Kevin T., Maya E. Kotas, Sears, Dorothy D., Frederick, David W., Banks, Alexander S., Kotas, Maya E., Sonia Caprio, Paula Chatterjee, Dorothy D. Sears, Bhanot, Sanjay, Caprio, Sonia, Shulman, Gerald I., Erion, Derek M., Eric S. Muise, Matthew P. Gillum, Jerrold M. Olefsky, Shin Yonemitsu   +33 more
core   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Securidaca inappendiculata Extract Mitigates Joint Damage in Collagen-Induced Arthritis Rats Through Modulation of the SIRT1/HIF-1α/Glycolysis Pathway. [PDF]

Pharmacol Res Perspect
ABSTRACT Securidaca inappendiculata (SI) Hassk. is a traditional Chinese herbal medicine commonly used in Southern China for the treatment of rheumatoid arthritis (RA). However, its exact mechanism of action remains unclear. In this study, we evaluated the therapeutic effects of the SI‐derived compound 1,7‐dihydroxy‐3,4‐dimethoxyxanthone (XAN) in a ...
Zhou Y, Zhou Y, Xiang R, Liu X, Wang T, Chen X, Wang G.   +6 more
europepmc   +2 more sources

Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo

, 2013
Sirtuins (SIRT1-7) are a highly conserved family of NAD(+)-dependent enzymes that control the activity of histone and nonhistone regulatory proteins. SIRT1 is purposed to promote longevity and to suppress the initiation of some cancers.
Candinas, Daniel, Lämmle, Alexander, Overney, Sarah, Lechleiter, Antje, Tschan, Mario, Mikami, Kei, Keogh, Adrian, Portmann, Simone, Fahrner, René, Montani, Matteo, Keogh-Stroka, Deborah M.   +10 more
core   +1 more source

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

Polydatin Alleviates APAP‐Induced Hepatotoxicity by Targeting C/EBPβ to Suppress the NLRP3 Inflammasome Signaling Pathway

iNew Medicine, EarlyView.
PD alleviates APAP‐induced ALI by inhibiting the NLRP3 inflammasome signaling pathway. C/EBPβ is identified as a direct target via multimethod validation. PD promotes the deacetylation of C/EBPβ via Sirt1. The Sirt1/C/EBPβ/NLRP3 signaling axis is defined for PD's hepatoprotective effect.
Tian‐Yu Yang, Chen Wang, Yi Ding, Wei‐Kang Zhang, Ling Zheng, Li Yue, Lei Zhang   +6 more
wiley   +1 more source

JNK2-dependent regulation of SIRT1 protein stability

, 2008
Mammalian SIRT1 is an NAD-dependent deacetylase with critical roles in the maintenance of homeostasis and cell survival. Elevated levels of SIRT1 protein are evident in cancer in which SIRT1 can function as a cancer-specific survival factor.
Ahmed, Shafiq U., Jack Ford, Simon Allison, Shafiq Ahmed, Jo Milner, Ming Jiang, Allison, Simon J., Jiang, Ming, Milner, Jo, Ford, Jack   +9 more
core   +1 more source