Results 181 to 190 of about 7,699 (204)
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Molecular and Cellular Biochemistry, 2023
Sirtuin 7 (SIRT7) is a member of the sirtuin family and has emerged as a key player in numerous cellular processes. It exhibits various enzymatic activities and is predominantly localized in the nucleolus, playing a role in ribosomal RNA expression, DNA damage repair, stress response and chromatin compaction.
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Sirtuin 7 (SIRT7) is a member of the sirtuin family and has emerged as a key player in numerous cellular processes. It exhibits various enzymatic activities and is predominantly localized in the nucleolus, playing a role in ribosomal RNA expression, DNA damage repair, stress response and chromatin compaction.
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Quantitative proteome‐based systematic identification of SIRT7 substrates
Proteomics, 2017SIRT7 is a class III histone deacetylase that is involved in numerous cellular processes. Only six substrates of SIRT7 have been reported thus far, so we aimed to systematically identify SIRT7 substrates using stable‐isotope labeling with amino acids in cell culture (SILAC) coupled with quantitative mass spectrometry (MS).
Ming Tang, Tingting Li, Wei-Guo Zhu
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Cyclic tripeptide-based potent human SIRT7 inhibitors
Bioorganic & Medicinal Chemistry Letters, 2019In the current study, two cyclic tripeptides respectively harboring a thiourea-type and a carboxamide-type of catalytic mechanism-based sirtuin inhibitory warheads as the central residue were found to behave as potent (low μM level) inhibitors against the tRNA-activated human SIRT7 deacetylase activity.
Shengchao, Li, Bo, Wu, Weiping, Zheng
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SIRT7 Exhibits Oncogenic Potential in Human Ovarian Cancer Cells
Asian Pacific Journal of Cancer Prevention, 2015 Sirtuin7 (SIRT7) is a type of nicotinamide adenine dinucleotide oxidized form (NAD+)-dependent deacetylase and the least understood member of the sirtuins family; it is implicated in various processes, such as aging, DNA damage repair and cell signaling transduction. There is some evidence that SIRT7 may function as a tumor trigger for human malignancy.
Hong-Ling, Wang +6 more
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Mammalian Sirtuins SIRT4 and SIRT7
2018Sirtuins are a family of intracellular enzymes whose enzymatic activities include catalyzing the β-nicotinamide adenine dinucleotide (β-NAD+)-dependent Nɛ-acyl-lysine deacylation and the β-NAD+-dependent mono-ADP-ribosylation. Among the seven sirtuin family members (i.e., SIRT1-7) thus far identified in mammals including humans, we know SIRT1/2/3/5/6 ...
Shengchao, Li, Weiping, Zheng
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Clinicopathological and molecular analysis of SIRT7 in hepatocellular carcinoma
Pathology, 2020Sirtuin 7 (SIRT7) is a NAD+ (nicotinamide adenine dinucleotide) dependent deacetylase that is reported to contribute to tumour growth and invasion by selectively acting on histone H3K18. It is overexpressed in several cancers including hepatocellular carcinoma (HCC).
Masae Yanai +9 more
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Transcriptional Regulation of Metabolism by SIRT1 and SIRT7
2018Sirtuins are a family of evolutionally conserved nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylases/deacylases that regulate metabolism. The mammalian sirtuin family consists of seven sirtuins (SIRT1-7). Recent findings have identified critical roles for SIRT1 and SIRT7 in glucose/lipid metabolism in multiple tissues.
Kazuya, Yamagata, Tatsuya, Yoshizawa
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Novel protein–protein interactions of TPPII, p53, and SIRT7
Molecular and Cellular Biochemistry, 2015Novel protein-protein interactions of TPPII, SIRT7, and p53 were detected by co-immunoprecipitation using both HeLa cell lysates and the cytoplasmic fraction prepared by fractionation of mouse liver tissue. The interactions were further verified in vivo by in situ proximity ligation assay (PLA) within control HEK293 cells transformed with empty vector,
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Role of the epigenetic factor Sirt7 in neuroinflammation and neurogenesis
Neuroscience Research, 2018Epigenetic regulators are increasingly recognized as relevant modulators in the immune and nervous system. The class of sirtuins consists of NAD+-dependent histone deacetylases that regulate transcription. Sirtuin family member Sirt1 has already been shown to influence the disease course in an animal model of autoimmune neuroinflammation (experimental ...
Nicolas, Burg +2 more
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