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SIRT7 an emerging sirtuin: deciphering newer roles.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2014Sirtuin7 (SIRT7) is a NAD(+)-dependent protein deacetylase which belongs to sirtuin family. Although sirtuin proteins have attracted a great deal of attention, little is known about SIRT7. SIRT7 participates in rDNA transcription in the nucleolus. However, recent reports show that SIRT7 has additional novel functions.
W, Kim, J E, Kim
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[Progress in roles and mechanisms of deacetylase SIRT7].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2019As a member of the Sirtuins family in mammals, SIRT7 locates in nucleus and is a highly specific H3K18Ac (acetylated lysine 18 of histone H3) deacetylase. Recent studies showed that SIRT7 could participate in the ribosomal RNA transcription, cell metabolism, cell stress and DNA damage repair through various signaling pathways.
Lin, Li +7 more
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Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal
FEBS Journal, 2013Shashi Kiran, Sunil C Kaul, Renu Wadhwa
exaly
Inhibition of H3K18 deacetylation of Sirt7 by Myb-binding protein 1a (Mybbp1a)
Biochemical and Biophysical Research Communications, 2013Tatsuya Yoshizawa +2 more
exaly
Identification of a novel SIRT7 inhibitor as anticancer drug candidate
Biochemical and Biophysical Research Communications, 2019Ji-Hye Kim, Jong-Hoon Kim
exaly