Results 161 to 170 of about 44,793 (241)

Examining Sirtuin-1 Levels and Inflammation Markers in Behcet's Disease: A Pilot Study. [PDF]

Arch Rheumatol
Ecesoy V, Arıcı H, Ateş FP, Osmanoğlu UÖ, Ecesoy H.   +4 more
europepmc   +1 more source

The evolving landscape of the Warburg effect in gastric cancer: From molecular mechanisms to targeted therapy

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Hypoxia, oncogenic signaling, transcriptional and epigenetic remodeling, and H. pylori–microbiota interactions drive the Warburg effect in gastric cancer. Enhanced glycolysis and lactate export support biosynthesis, remodel the tumor microenvironment, promote stromal activation and immune suppression, and reveal actionable biomarkers and therapeutic ...
Guanmo Liu, Pan Li, Zizhuo Li, Jie Li, Chenggang Zhang, Yihua Wang, Weiming Kang, Xin Ye   +7 more
wiley   +1 more source

Trichosanthes kirilowii Maximowicz attenuates dexamethasone induced atrophy in C2C12 myotubes through a Sirtuin 1 associated mechanism. [PDF]

Sci Rep
Kim H, Hong JY, Yeo C, Jeon WJ, Kim H, Lee J, Lee YJ, Ha IH.   +7 more
europepmc   +1 more source

Editorial: Leptin Resistance in Metabolic Disorders: Possible Mechanisms and Treatments

Frontiers in Endocrinology, 2017
Toru Hosoi, Margherita Maffei, Margherita Maffei   +2 more
doaj   +1 more source

Overexpression of long noncoding RNA colorectal neoplasia differentially expressed protects spinal cords against ischemia by targeting microRNA-181a-5p/Sirtuin-1 axis. [PDF]

Front Neurol
Wang Z, Wang W, Tang R, Gao S, Zhu Y, Gu T, Jiang X, Shi E.   +7 more
europepmc   +1 more source

A neuroprotective role for sirtuin 1 [PDF]

Nature Reviews Drug Discovery, 2012
openaire   +1 more source

Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic‐Therapeutic Directions of Cardiovascular Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie, Qun Zeng, Hongrui Wang, Meihua She   +3 more
wiley   +1 more source

Evaluation of Sirtuin 1 (SIRT1) and Sirtuin 3 (SIRT3) in serum and cerebrospinal fluid following fatal traumatic brain injury. [PDF]

Int J Legal Med
Poniatowski ŁA, Siwińska A, Kwiatkowska M, Olczak M.   +3 more
europepmc   +1 more source

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao, Yun Liang, Xinwen Liang, Qisheng Su, Xiaohong Li   +4 more
wiley   +1 more source

Comment on “Renal Protective Effect of Sirtuin 1”

Journal of Diabetes Research, 2015
Kultigin Turkmen
doaj   +1 more source