Results 171 to 180 of about 44,793 (241)

Taurine, Sirtuin-1 and TNF- α levels in different aged adults with periodontitis: a pilot study. [PDF]

BMC Oral Health
Sayedyousef H, Yilmaz O, Ozturk C, Demir B, Toygar HU, Balci N.   +5 more
europepmc   +1 more source

Sirtuin 1 (SIRT1); SIRT2 [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Dexpanthenol Attenuates Methotrexate‐Induced Nephrotoxicity Through Modulation of NF‐κB–Mediated Inflammation and SIRT1/PGC‐1α–NRF2/HO‐1–Associated Oxidative Stress Pathways

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Graphical abstract depicting the protective role of DEX against MTX‐induced nephrotoxicity. MTX exposure activates NF‐κB, leading to upregulation of TNF‐α and downstream apoptotic mediator Cas‐3, which collectively drive inflammation, apoptosis, and renal tissue damage. Simultaneously, MTX suppresses protective regulators SIRT1, PGC‐1α, NRF2, and HO‐1,
Atila Altuntas, Halil Asci, Esma Selcuk, Huzeyfe Karaosman, Osman Aydin, Ilter Ilhan, Sefa Alperen Ozturk, Ozlem Ozmen   +7 more
wiley   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong, Zhen Wang, Xiaoxiao Lin, Ziwen Lei, Qianqian Huang, Hang Liu, Fei Luan, Junbo Zou, Yajun Shi   +8 more
wiley   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection. [PDF]

Adv Sci (Weinh)
Bi K, Xu B, Cao D, Xu K, Zhang Y.
europepmc   +1 more source

A Sirtuin-1-Targeted Gene-Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1-FOXO3-BNIP3 Axis. [PDF]

Adv Sci (Weinh)
Wang W, Yan R, Lin L, Xiang L, Xia X, Peng L, Gao X, Chen J, Xiong Y, Zhou L, Lin Y.   +10 more
europepmc   +1 more source

Isothiocyanates as Ferroptosis Inducers to Promote Cancer Cell Death

Phytotherapy Research, Volume 40, Issue 8, Page 5119-5131, August 2026.
ABSTRACT Cancer remains a leading cause of global mortality, with the therapeutic efficacy of anticancer drugs often hampered by late diagnosis and the development of chemotherapy resistance. Ferroptosis is an iron‐dependent form of regulated non‐apoptotic cell death driven by lipid peroxidation.
Valentina Citi, Renda Chahna, Francesca Maffei, Alma Martelli, Vincenzo Calderone, Carmela Fimognari, Eleonora Turrini   +6 more
wiley   +1 more source

Elevated Sirtuin 1 Levels in Patients with Chronic Kidney Disease, Including on Peritoneal Dialysis: Associations with Cardiovascular Risk and Peritoneal Fibrosis. [PDF]

Int J Mol Sci
Bielach-Bazyluk A, Czajkowska K, Koc-Zorawska E, Hryszko T, Zbroch E.   +4 more
europepmc   +1 more source