Staging concept for aging management: Definition, mechanism, and coping strategies
VIEW, Volume 7, Issue 4, August 2026.We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang +6 more
wiley +1 more source
Alisertib Induces Cell Cycle Arrest and Autophagy and Suppresses Epithelial-to-Mesenchymal Transition Involving PI3K/Akt/mTOR and Sirtuin 1-Mediated signaling pathways in Human Pancreatic Cancer Cells [Retraction]. [PDF]
Drug Des Devel Thereuropepmc +1 more source
Sirtuin-1 directly binds and deacetylates hepatic PCSK9 thereby promoting the inhibition of LDL receptor degradation. [PDF]
Cardiovasc ResVelagapudi S +20 more
europepmc +1 more source
Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Teng Zhang, Ting Wang, Yuan Fu
wiley +1 more source
Recent Advances in the Molecular Mechanisms of Bacterial Anti‐Phage Defence Systems
Microbial Biotechnology, Volume 19, Issue 8, August 2026.Panoptes as an example for an antiphage system consists of OptS producing a cyclic dinucleotide that prevents activation of OptE, a transmembrane protein. Phage T4 infection introduces the sponge protein Acb2 that adsorbs the cyclic dinucleotide thus activating OptE which disrupts the cell membrane aborting phage infection.
Harald Brüssow
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Aging Cell, Volume 25, Issue 8, August 2026.This study investigated the effects of nicotinamide riboside supplementation and high‐intensity interval training on skeletal muscle epigenetic aging. Our findings reveal that both interventions may modify epigenetic aging, with the muscle‐specific MEAT and DunedinPACE clocks showing the most responsiveness and links to mitochondrial abundance ...
Aino Heikkinen +17 more
wiley +1 more source
Diagnostic Value of Sirtuin-1 in Predicting Contrast-Induced Nephropathy After Percutaneous Coronary Intervention. [PDF]
J Clin MedArdic M, Gul CB.
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Ammonia Metabolism in the Aging Liver: Emerging Mechanistic Insights
Aging Cell, Volume 25, Issue 8, August 2026.Liver aging may weaken ammonia‐detoxification reserve by disrupting mitochondrial ureagenesis, GS‐mediated scavenging, glutamine metabolism, and metabolic zonation. This emerging framework links impaired nitrogen handling to potential hepatic stress amplification and systemic crosstalk, while highlighting the need for direct validation in physiological
Heng Zhang, Guangyu Liang, Anding Liu
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Correction: Berberine ameliorates subarachnoid hemorrhage injury via induction of Sirtuin 1 and inhibiting HMGB1/Nf-κB pathway. [PDF]
Front PharmacolZhang XH +7 more
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Aging Cell, Volume 25, Issue 8, August 2026.Age‐related downregulation of AcSirt2 impairs mitochondrial homeostasis in old bees. AcSirt2‐mediated deacetylation of FOXO enhances transcriptional activity, upregulating antioxidant enzymes (SOD, CAT) and promoting PINK1/Parkin‐mediated mitophagy. This pathway facilitates autophagosome formation and clearance of damaged mitochondria, reducing ROS ...
Qiang Ma +8 more
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