Results 121 to 130 of about 84,834 (402)

Cyclic Peptide-Based Sirtuin Substrates

Molecules, 2019
In the current study, four side chain-to-side chain cyclic peptides (three 5-mers and one 4-mer) harboring Nε-acetyl-lysine or Nε-myristoyl-lysine were found to be in vitro substrates of the human SIRT1/2/3-catalyzed deacylation with good ...
Di Chen, Lingling Yan, Weiping Zheng
doaj   +1 more source

Natural Products as Modulators of Sirtuins

Molecules, 2020
Natural products have been used for the treatment of human diseases since ancient history. Over time, due to the lack of precise tools and techniques for the separation, purification, and structural elucidation of active constituents in natural resources
Berin Karaman Mayack, Wolfgang Sippl, Fidele Ntie-Kang   +2 more
doaj   +1 more source

Characterization of Sirt2 using conditional RNAi in mice [PDF]

, 2011
Within the past eight years, RNA interference (RNAi) has emerged as a powerful experimental tool for gene function analysis in mice. Reversible control of shRNA mediated RNAi has been achieved by using a tetracycline (tet)-inducible promoter.
Reiss, Martina
core  

Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity [PDF]

, 2016
Background and aim: Obesity is increasing worldwide and is related to undesirable cardiovascular outcomes. Epicardial fat (EF), the heart visceral fat depot, increases with obesity and correlates with cardiovascular risk.
A. Lenzi, C. Caldaroni, C. Lubrano, D. Costantini, E. Poggiogalle, G. Barbaro, L. Gnessi, L.M. Donini, S. Basciani, S. Mariani   +9 more
core   +1 more source

Noncoding RNAs in Host–Microbiota Interaction

Animal Research and One Health, EarlyView.
The intricate interplay between gut microbiota and the host exerts a profound impact on host biological processes and disease development. This review highlights the pivotal role of noncoding RNAs (ncRNAs) in this interaction. Host ncRNAs regulate gene expression and microbiota composition, whereas microbial small RNAs (sRNAs) modulate host gene ...
Ziyi Zhao, Ni Li, Jingyi Xu, Jianrong Ren, Xiaojun Yang, Xinyi Li, Junhu Yao, Shengru Wu   +7 more
wiley   +1 more source

A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues [PDF]

, 2017
For the synthesis of m-sulfamoylbenzamide analogues, small molecules which are known for their bioactivity, a chemoselective procedure has been developed starting from m-(chlorosulfonyl) benzoyl chloride.
Heugebaert, Thomas, Kerchev, Pavel, Stevens, Christian, Van Breusegem, Frank, van der Meer, Tom, Verlee, Arno   +5 more
core   +3 more sources

Spermidine reproduces the anti‐inflammatory effects of intermittent fasting and prevents urate and calcium pyrophosphate crystal‐induced inflammation

Arthritis &Rheumatology, Accepted Article.
Background Gout due to the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent flares that rely on interleukin (IL)‐1β via activation of the NLRP3 inflammasome.
Chinh Nghia Pham, Florence Castelli, Flora Finet, Charles Leroy, Céline Chollet, Twinu Wilson Chirayath, Subhalaxmi Moitra, Mylène Zarka, Agnès Ostertag, François Brial, Christèle Combes, Augustin Latourte, Thomas Bardin, François Fenaille, Pascal Richette, Hang Korng Ea   +15 more
wiley   +1 more source

Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3

Cell Reports, 2018
Summary: Sirtuin 3 (SIRT3) is a NAD+-dependent deacetylase downregulated in aging and age-associated diseases such as cancer and neurodegeneration and in high-fat diet (HFD)-induced metabolic disorders.
Karina N. Gonzalez Herrera, Elma Zaganjor, Yoshinori Ishikawa, Jessica B. Spinelli, Haejin Yoon, Jia-Ren Lin, F. Kyle Satterstrom, Alison Ringel, Stacy Mulei, Amanda Souza, Joshua M. Gorham, Craig C. Benson, Jonathan G. Seidman, Peter K. Sorger, Clary B. Clish, Marcia C. Haigis   +15 more
doaj   +1 more source

Sirtuin 1: A Dilemma in Transplantation

Journal of Transplantation, 2020
Sirtuin 1, a member of sirtuin family of histone deacetylase enzymes, has been implicated in a variety of physiologic and pathologic events, including energy metabolism, cell survival, and age-related alterations.
Sara Assadiasl, Nuala Mooney, Bahareh Mohebbi, Yousef Fatahi, Narjes Soleimanifar   +4 more
doaj   +1 more source

The role of sirtuin 1 and its activator, resveratrol in osteoarthritis

Bioscience Reports, 2019
Osteoarthitis (OA) is the most common aging-related joint pathology; the aging process results in changes to joint tissues that ultimately contribute to the development of OA. Articular chondrocytes exhibit an aging-related decline in their proliferative
Zhenhan Deng, Yusheng Li, Haifeng Liu, Shengshi Xiao, Liangjun Li, Jian Tian, Chao Cheng, Greg Zhang, Fangjie Zhang   +8 more
semanticscholar   +1 more source