Results 131 to 140 of about 45,770 (169)
Some of the next articles are maybe not open access.
The Substrate Specificity of Sirtuins
Annual Review of Biochemistry, 2016Sirtuins are NAD + -dependent enzymes universally present in all organisms, where they play central roles in regulating numerous biological processes.
Bheda, Poonam +3 more
openaire +3 more sources
The Many Faces of Sirtuins: Sirtuins and the Warburg effect
Nature Medicine, 2014Metabolic regulators that permit adaptation to changes in caloric intake have been shown to be needed to protect from age-related disorders. Sirtuins play a crucial part in this program, impinging on not only aging but also other diseases. New findings are uncovering the multifaceted activity of sirtuins in living organisms and their effects on ...
openaire +2 more sources
Flavonoids as Sirtuin Modulators
Current Topics in Medicinal Chemistry, 2022Abstract: Sirtuins (SIRTs) are described as NAD+-dependent deacetylases, also known as class III histone deacetylases. So far, seven sirtuin genes (SIRTS 1–7) have been identified and characterized in mammals and also known to occur in bacteria and eukaryotes.
Deniz, FATMA SEZER +2 more
openaire +3 more sources
Epigenetics, sirtuins and osteoarthritis
Joint Bone Spine, 2012Epigenetics, modifications of the DNA other than changes on the DNA sequences, is frequently studied in cancer research and aging. DNA methylation, mi-RNA, and histones deacetylation are investigated in different pathologies, including inflammatory diseases and age-related diseases such as osteoarthritis (OA).
Gabay, Odile, Sanchez, Christelle
openaire +2 more sources
The brain, sirtuins, and ageing
Nature Reviews Neuroscience, 2017In mammals, recent studies have demonstrated that the brain, the hypothalamus in particular, is a key bidirectional integrator of humoral and neural information from peripheral tissues, thus influencing ageing both in the brain and at the 'systemic' level.
Akiko, Satoh +2 more
openaire +2 more sources
Mitochondrial sirtuins in the heart
Heart Failure Reviews, 2016Sirtuins (SIRTs) are NAD(+)-dependent enzymes that catalyze deacylation of protein lysine residues. In mammals, seven sirtuins have been identified, SIRT1-7. SIRT3-5 are mainly or exclusively localized within mitochondria and mainly participate in the regulation of energy metabolic pathways.
Heiko Bugger +2 more
openaire +3 more sources
A Review on SIRtuins in Diabetes
Current Pharmaceutical Design, 2017Type-2 Diabetes is a long lasting disease characterized by high glucose concentration in the blood due to insulin resistance. One of the recent treatment strategies is using activators against SIRT-1, which has been in clinical trials. Hence, it is necessary to know the effects of the SIRT-1 modulators against various metabolic pathways.Many cellular ...
R, Aditya +4 more
openaire +2 more sources
Sirtuins' modulation of autophagy
Journal of Cellular Physiology, 2013AbstractThe sirtuin family of class III histone deacetylases has been extensively implicated in modulating a myriad of cellular processes, including energy metabolism, stress response, cell/tissue survival and malignancy. Recent studies have also identified multifaceted roles for Sirt1 and Sirt2 in the regulation of autophagy.
Fanny, Ng, Bor Luen, Tang
openaire +2 more sources
Sirtuins and the prevention of immunosenescence
2021Aging of hematopoietic stem cells (HSCs) has been largely described as one underlying cause of senescence of the immune-hematopoietic system (immunosenescence). A set of well-defined hallmarks characterizes aged HSCs contributing to unbalanced hematopoiesis and aging-associated functional alterations of both branches of the immune system.
openaire +2 more sources
Mitochondrial sirtuin 3 and various cell death modalities
Frontiers in Cell and Developmental Biology, 2022Boris Zhivotovsky +2 more
exaly