Results 121 to 130 of about 45,770 (169)
Molecular mechanisms underlying Parkinson's disease and role of phytochemicals, α-synuclein, sirtuins, and incretin mimetics in potential therapy. [PDF]
Front PharmacolJuthi SS +9 more
europepmc +1 more source
Sirtuin 1 and Sirtuin 2 Gene Expressions in Colorectal Cancers. [PDF]
J Clin Pract ResDüzenli T, Doğan D, Barışık NÖ.
europepmc +1 more source
Thomas Willis Lecture Award: Nature's Blueprint for Ischemic Tolerance: Preconditioning and Postconditioning Strategies. [PDF]
StrokePerez-Pinzon MA.
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An integrated anti-aging framework targeting NAD<sup>+</sup> homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT. [PDF]
Redox BiolSun Y +5 more
europepmc +1 more source
Lactylation in cardiac repair: Nexus and therapeutic opportunity. [PDF]
J Mol Cell Cardiol PlusGuo F +9 more
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Expert Opinion on Therapeutic Patents, 2009
The sirtuin family of deacetylase enzymes comprises seven proteins (SIRT1-7) that are dependent on NAD(+) for their activity. Three proteins are located in the nucleus, three in the mitochondria and only one is predominantly cytoplasmic. Caloric restriction and oxidative stress generally up-regulate their expression. SIRT1, the orthologue of yeast Sir2,
Francisco J, Alcaín, José M, Villalba
openaire +2 more sources
The sirtuin family of deacetylase enzymes comprises seven proteins (SIRT1-7) that are dependent on NAD(+) for their activity. Three proteins are located in the nucleus, three in the mitochondria and only one is predominantly cytoplasmic. Caloric restriction and oxidative stress generally up-regulate their expression. SIRT1, the orthologue of yeast Sir2,
Francisco J, Alcaín, José M, Villalba
openaire +2 more sources
Expert Opinion on Therapeutic Patents, 2009
Sirtuin 1-7 (SIRT1-7) are deacetylases that are dependent on NAD(+) for their activity. SIRT1 down-regulates p53 activity, increasing lifespan, cell survival, and neuroprotection; it also deacetylates peroxisome proliferator-activated receptor-gamma and its coactivator 1alpha, promoting fat mobilization, increasing mitochondrial size and number, and ...
Francisco J, Alcaín, José M, Villalba
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Sirtuin 1-7 (SIRT1-7) are deacetylases that are dependent on NAD(+) for their activity. SIRT1 down-regulates p53 activity, increasing lifespan, cell survival, and neuroprotection; it also deacetylates peroxisome proliferator-activated receptor-gamma and its coactivator 1alpha, promoting fat mobilization, increasing mitochondrial size and number, and ...
Francisco J, Alcaín, José M, Villalba
openaire +2 more sources
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2010
Sirtuins have emerged as important proteins in aging, stress resistance and metabolic regulation. Three sirtuins, SIRT3, 4 and 5, are located within the mitochondrial matrix. SIRT3 and SIRT5 are NAD(+)-dependent deacetylases that remove acetyl groups from acetyllysine-modified proteins and yield 2'-O-acetyl-ADP-ribose and nicotinamide.
Jing-Yi, Huang +4 more
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Sirtuins have emerged as important proteins in aging, stress resistance and metabolic regulation. Three sirtuins, SIRT3, 4 and 5, are located within the mitochondrial matrix. SIRT3 and SIRT5 are NAD(+)-dependent deacetylases that remove acetyl groups from acetyllysine-modified proteins and yield 2'-O-acetyl-ADP-ribose and nicotinamide.
Jing-Yi, Huang +4 more
openaire +2 more sources
Annual Review of Biochemistry, 2006
Sirtuins are a family of NAD+-dependent protein deacetylases widely distributed in all phyla of life. Accumulating evidence indicates that sirtuins are important regulators of organism life span. In yeast, these unique enzymes regulate gene silencing by histone deacetylation and via formation of the novel compound 2′-O-acetyl-ADP-ribose.
Anthony A, Sauve +3 more
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Sirtuins are a family of NAD+-dependent protein deacetylases widely distributed in all phyla of life. Accumulating evidence indicates that sirtuins are important regulators of organism life span. In yeast, these unique enzymes regulate gene silencing by histone deacetylation and via formation of the novel compound 2′-O-acetyl-ADP-ribose.
Anthony A, Sauve +3 more
openaire +2 more sources
2021
Sirtuins are involved in numerous biological processes such as cell survival and metabolism, aging, and DNA repair; thus they modulate crucial metabolic pathways. The seven members of the Sirtuin family are more and more seen as potential targets for the treatment of cancer, metabolic, neurodegenerative, and cardiovascular diseases.
Zwergel, Clemens +2 more
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Sirtuins are involved in numerous biological processes such as cell survival and metabolism, aging, and DNA repair; thus they modulate crucial metabolic pathways. The seven members of the Sirtuin family are more and more seen as potential targets for the treatment of cancer, metabolic, neurodegenerative, and cardiovascular diseases.
Zwergel, Clemens +2 more
openaire +1 more source