Results 291 to 300 of about 84,834 (402)

Sirtuins in Central Nervous System Tumors-Molecular Mechanisms and Therapeutic Targeting. [PDF]

Cells
Nowacka A, Śniegocka M, Śniegocki M, Ziółkowska EA.   +3 more
europepmc   +1 more source

The Contentious History of Sirtuin Debates [PDF]

, 2012
Shoshana Naiman, Haim Cohen
openalex   +1 more source

Osteoblast‐CD4+ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age‐Related Bone Loss

Advanced Science, Volume 12, Issue 39, October 20, 2025.
In the osteoblastic niche, SIRT1 activates and recruits CD4+ CTLs by increasing DAAM2 expression via EZH2 deacetylation and boosting the secretion of key chemokines, such as CCL3, CCL5, and CXCL10. Then, CD4+ CTL directly eliminates senescent osteoblasts in an MHC‐II‐dependent way, thereby slowing down the process of bone ageing and effectively ...
Bin Yang, Guofu Zhang, Yizhou Zhu, Jingcheng Wang, Xinmin Feng, Wenyong Fei, Jihang Dai, Le Hu, Yi Zhang, Jun Cai, Binjia Ruan, Yue Jin, Fanhao Wei, Gang Lu, Dongan Wang, Jason Pui Yin Cheung, Graham Ka Hon Shea, Hao Chen, Kelvin Wai Kwok Yeung, Lei Wang, Yongxiang Wang   +20 more
wiley   +1 more source

The impacts of different dietary restriction regimens on aging and longevity: from yeast to humans. [PDF]

J Biomed Sci
Ching TT, Hsu AL.
europepmc   +1 more source

Sorting out the sirtuins [PDF]

, 2012
David B. Lombard, Richard A. Miller
openalex   +1 more source

Cardiovascular Disease Meets Cancer: Exploring the Epidemiology in China and Homotherapy Targeting Intersectional Mechanisms

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang, Yujie Shan, Shihong Xu, Jing Wang, Meng Luo, Jiaojiao Zhou, Qishan Chen   +6 more
wiley   +1 more source

Role of SIRT6 in Chronic Periodontitis and Osteogenic Differentiation of Periodontal Ligament Stem Cells. [PDF]

Int Dent J
Guo H, Liu R, Xu H, Pan J, Gu H.
europepmc   +1 more source

From Sirtuin Biology to Human Diseases: An Update

, 2012
Carlos Sebastián, F. Kyle Satterstrom, Marcia C. Haigis, Raúl Mostoslavsky   +3 more
openalex   +1 more source

H2O2‐Activated Serotonin Precursor Probe for Mapping Neuronal Redox Homeostasis Reveals 5‐HT Interactions with Neighboring Proteins Under Oxidative Stress

Advanced Science, Volume 12, Issue 39, October 20, 2025.
HOP, an innovative ICT‐based fluorescent probe, visualizes H2O2 in stressed neurons while locally releasing serotonin (5‐HT) for real‐time protein interaction mapping. Its unique tandem sensing and labeling strategy reveals 5‐HT's role under oxidative stress, offering a powerful tool for neurophysiological research and therapeutic discovery.
Yani Liu, Jiwen Yuan, Tuanjie Zhang, Xinyi Cai, Meng Xu, Xueao Wang, Rui Wang, Bing Zhang, Hai‐Liang Zhu, Yong Qian   +9 more
wiley   +1 more source

Placental Expression of Sirtuins in Women with Gestational Diabetes. [PDF]

Genes (Basel)
Czerewaty M, Ustianowski Ł, Kiełbowski K, Bakinowska E, Safranow K, Tarnowski M, Sroczyński T, Pawlik A.   +7 more
europepmc   +1 more source