Results 301 to 310 of about 84,834 (402)

The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5)

, 2012
Yeyun Zhou, Hongmin Zhang, Bin He, Jintang Du, Hening Lin, Richard A. Cerione, Quan Hao   +6 more
openalex   +1 more source

Entwined processes in Alzheimer's disease: Brain cellular senescence and Alzheimer's disease pathology

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract Alzheimer's disease (AD) is one of the most common age‐related neurodegenerative diseases with severe progressive dementia. Amyloid beta (Aβ) deposition and phosphorylated tau accumulation are two typical AD pathologies, which could drive senescence in various types of brain cells.
Wen Li, Ying Han, Peichang Wang, Qiao Song   +3 more
wiley   +1 more source

Sirtuin Expression in Age-Associated Hepatic Response to Burn Trauma: Translational and Clinical Insights From a Murine Model. [PDF]

Cureus
Meza Monge K, Qualman AC, Pratap A, Kovacs EJ, Idrovo JP.   +4 more
europepmc   +1 more source

Ononin, a Natural Isoflavone Glycoside, Alleviates Postoperative Cognitive Dysfunction in Aged Mice by Regulating Neuroinflammation and Oxidative Stress

Brain and Behavior, Volume 15, Issue 10, October 2025.
Ononin alleviates postoperative cognitive dysfunction in aged mice by regulating neuroinflammation and oxidative stress. ABSTRACT Objective Postoperative cognitive dysfunction (POCD) is a serious neurological complication that currently lacks effective clinical prevention and treatment.
Ming Li, Qingmei Peng, Min Zhu, Qilin Liu, Simin Yang, Cansheng Gong, Jingyan Lin, Qingbo Yu   +7 more
wiley   +1 more source

The impact of aging on liver health and the development of liver diseases. [PDF]

Hepatol Commun
Williams SN, Ding WX.
europepmc   +1 more source

Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury.

Kidney International, 2018
Q. Hong, Lu Zhang, B. Das, Zhengzhe Li, Bohan Liu, G. Cai, Xiangmei Chen, Peter Y. Chuang, J. He, Kyung Lee   +9 more
semanticscholar   +1 more source

Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1

, 2012
Weijing Cai, Maya Ramdas, Li Zhu, Xue Chen, Gary E. Striker, Helen Vlassara   +5 more
openalex   +1 more source

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, Volume 45, Issue 10, Page 1247-1284, October 2025.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

Role of novel protein acylation modifications in sepsis. [PDF]

Front Immunol
Wang J, He A, Song L, Jiang W, Xu L, Zheng R, Yu J.   +6 more
europepmc   +1 more source

Individual and Comorbid Influences of Chronic Stress and a Western Diet on Allostatic Loads and Cardiac Resilience, Adaptation and Proteome Profiles in Male Mice

Comprehensive Physiology, Volume 15, Issue 5, October 2025.
These findings support positive interactions between common risk factors in comorbid development of cardiovascular and affective disorders. Mitochondrial and innate defense paths may contribute to the influences of diet, stress, and preconditioning.
Makayla Nicholas, Tessa Helman, Brock Lyon, Saba Naghipour, Trissha Ybanez, Joshua T. Ingles, Chulkyu Kim, Nicolas J. C. Stapelberg, Jason N. Peart, John P. Headrick, Eugene F. du Toit   +10 more
wiley   +1 more source