Results 81 to 90 of about 84,834 (402)
Microbial Cell, 2016 Increasing the stability or dynamics of the actin cytoskeleton can extend lifespan in C. elegans and S. cerevisiae. Actin cables of budding yeast, bundles of actin filaments that mediate cargo transport, affect lifespan control through effects on ...
Ryo Higuchi-Sanabria +4 more
doaj +1 more source
International Journal of Molecular Sciences, 2021 Alternative splicing generates multiple distinct isoforms that increase transcriptome and proteome diversity. There are seven sirtuin genes in humans, each consists of multiple exons that are likely to undergo alternative splicing.
Xiaomin Zhang +3 more
semanticscholar +1 more source
The effects of graded levels of calorie restriction : XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome [PDF]
, 2017 We would like to acknowledge the BSU staff for their invaluable help with caring for the animals.Peer reviewedPublisher ...
Chen, Luonan +10 more
core +1 more source
New Insights for nicotinamide: Metabolic disease, autophagy, and mTOR
Frontiers in Bioscience-Landmark, 2020 Metabolic disorders, such as diabetes mellitus (DM), are increasingly becoming significant risk factors for the health of the global population and consume substantial portions of the gross domestic product of all nations. Although conventional therapies
Kenneth Maiese
doaj +1 more source
Current Trends in Sirtuin Activator and Inhibitor Development
MoleculesSirtuins are NAD+-dependent protein deacylases and key metabolic regulators, coupling the cellular energy state with selective lysine deacylation to regulate many downstream cellular processes.
Karina L Bursch +2 more
semanticscholar +1 more source
Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease [PDF]
, 2016 Background: Cigarette smoke induced oxidative stress has been shown to reduce silent information regulator 1 (Sirt1) levels in lung tissue from smokers and patients with COPD patients.
Akai, Masaya +11 more
core +2 more sources
The roles of sirtuins in ferroptosis
Frontiers in Physiology, 2023 Ferroptosis represents a novel non-apoptotic form of regulated cell death that is driven by iron-dependent lipid peroxidation and plays vital roles in various diseases including cardiovascular diseases, neurodegenerative disorders and cancers. Plenty of iron metabolism-related proteins, regulators of lipid peroxidation, and oxidative stress-related ...
Jieqing Zeng +8 more
openaire +3 more sources
The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases
Biomolecules, 2020 Chronic kidney disease (CKD) is one of the fastest growing causes of death worldwide, emphasizing the need to develop novel therapeutic approaches. CKD predisposes to acute kidney injury (AKI) and AKI favors CKD progression.
Miguel Fontecha-Barriuso +8 more
doaj +1 more source
Sirtuins in Epigenetic Regulation [PDF]
Chemical Reviews, 2015 1.1. Discovery of Sirtuins The founding member of sirtuin is the yeast-silencing information regulator 2 (SIR2) protein, one of four proteins (SIR1–4) required for silencing the mating-type information loci in yeast.1 SIR2–4, but not SIR1, are also required for gene silencing at telomeres.2 SIR2 also mediates gene silencing at the rDNA (rDNA) loci ...
Hui Jing, Hening Lin
openaire +3 more sources
SIRTUINS, AGING AND DISEASE [PDF]
The FASEB Journal, 2010 SIR2 and related genes are NAD‐dependent deacetylases that slow aging in yeast, C. elegans, and Drosophila. In yeast and flies, SIR2 genes are also involved in the longevity conferred by dietary or calorie restriction (CR). The mammalian SIR2 homologs termed SIRT genes, or sirtuins, are involved in changes in stress resistance and metabolism and are ...
openaire +3 more sources