Results 91 to 100 of about 63,033 (309)

DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks. [PDF]

, 2018
Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability.
Chen, Hongping, Choi, Eric T., Cueto, Ramon, Drosatos, Konstantinos, Fu, Hangfei, Nanayakkara, Gayani K, Park, Joon Y., Qin, Xuebin, Shao, Lijian, Shao, Ying, Sheng, Haitao, Sun, Jianxin, Sun, Yu, Wang, Hong, Wang, Luqiao, Wu, Na, Yang, Qian, Yang, William Y, Yang, Wuping, Yang, Xiaofeng, Zeng, Huihong, Zhu, Qingxian   +21 more
core   +2 more sources

The Fungal Metabolite Eurochevalierine, a Sequiterpene Alkaloid, Displays Anti-Cancer Properties through Selective Sirtuin 1/2 Inhibition

Molecules, 2018
NAD+-dependent histone deacetylases (sirtuins) are implicated in cellular processes such as proliferation, DNA repair, and apoptosis by regulating gene expression and the functions of numerous proteins.
Michael Schnekenburger, Véronique Mathieu, Florence Lefranc, Jun Young Jang, Marco Masi, Anake Kijjoa, Antonio Evidente, Hyun-Jung Kim, Robert Kiss, Mario Dicato, Byung Woo Han, Marc Diederich   +11 more
doaj   +1 more source

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease [PDF]

, 2011
Chronic obstructive pulmonary disease (COPD) is a global health problem, and current therapy for COPD is poorly effective and the mainstays of pharmacotherapy are bronchodilators.
Adenuga, Adenuga, Adenuga, Adenuga, Algood, Allison, Andersson, Andre, Anest, Arunachalam, Bannister, Barnes, Beeh, Bertolotti, Bessac, Biswal, Blake, Borchers, Borchers, Borchers, Bowie, Bracke, Caito, Caito, Calabrese, Capelli, Carrero, Carrozza, Celedon, Chen, Chen, Chen, Chen, Chen, Cheung, Cho, Christman, Church, Combadiere, Combadiere, Cosio, Costa, Csiszar, Cullinan, Cullinan, Dahl, De Boer, De Boer, de Boer, De Boer, de Ruijter, Decramer, Dekhuijzen, Dentener, Di Stefano, Dinarello, Donnelly, Duran, Edirisinghe, El Moussaoui, Facchinetti, Feghali-Bostwick, Ferrer, Foronjy, Franciosi, Furukawa, Galasinski, Ganguly, Gargalovic, Georgiou, Ghosh, Gongora, Goven, Gracie, Grumelli, Hardaker, Harding, Harju, Harju, Harrison, He, Hengstermann, Hogg, Hogg, Hongwei Yao, Hoshino, Hoshino, Hoshino, Hung, Hwang, Ichinose, Igishi, Iizuka, Imaoka, Imhof, Irfan Rahman, Ishii, Ito, Ito, Ito, Ito, Jorgensen, Juul, Kamei, Kang, Kang, Kasahara, Kassim, Kawahara, Keatings, Keatings, Kelsen, Kim, Kinnula, Kode, Kucukaycan, Lee, Lee, Lee, Leitges, Liu, Lukacs, Luo, Macnee, MacNee, Mahler, Mak, Malhotra, Mattagajasingh, McComb, Meja, Michaud, Michishita, Milne, Milne, Miotto, Mojtahedi, Moretti, Morrison, Motz, Murooka, Nakamaru, Nan, Netea, Niess, Ning, Nisoli, Nozik-Grayck, Ota, Ota, Pantano, Park, Pesci, Petersen, Petrache, Pinamonti, Porter, Potente, Potente, Rabe, Rahman, Rahman, Rahman, Rahman, Rajendrasozhan, Rajendrasozhan, Rangasamy, Rennard, Repine, Ryter, Rytila, Saetta, Saha, Saha, Sandford, Scherz-Shouval, Scherz-Shouval, Senftleben, Sengupta, Sethi, Sethi, Shapiro, Siedlinski, Simon, Singh, Siva, Sizemore, Soler, Sullivan, Sussan, Suzuki, Thatcher, Thomson, Tomaki, Traves, Trevisani, Tsoumakidou, Tuder, Turato, van der Pouw Kraan, van der Strate, van der Vlies, Van Gool, van Overveld, Vaziri, Vermeulen, Vlahos, Wang, Widdowson, Wright, Wright, Xiao, Yagi, Yamamoto, Yamato, Yang, Yang, Yang, Yang, Yang, Yang, Yao, Yao, Yao, Yao, Yin, Young, Zhang, Zhang, Zheng, Zochbauer-Muller   +230 more
core   +1 more source

Methylglyoxal-dependent glycative stress and deregulation of SIRT1 functional network in the ovary of PCOS mice [PDF]

, 2020
Advanced glycation end-products (AGEs) are involved in the pathogenesis and consequences of polycystic ovary syndrome (PCOS), a complex metabolic disorder associated with female infertility.
Amicarelli, F, Cristiano, L, D'Alessandro, AM, Emidio, GD, Falone, S, Nottola, S, Palmerini, MG, Placidi, M, Rea, F, Rossi, G, Tatone, C   +10 more
core   +1 more source

SGLT2 inhibitors for the prevention and treatment of heart failure: A scientific statement of the HFA and the HFAI

ESC Heart Failure, EarlyView.
Abstract In the 2021 European Society of Cardiology (ESC) heart failure (HF) guidelines, sodium–glucose cotransporter 2 (SGLT2) inhibitors were recommended for the prevention of HF in patients with type 2 diabetes mellitus (T2DM) and for the treatment of HF with reduced ejection fraction (HFrEF).
Marco Metra, Daniela Tomasoni, Marianna Adamo, Offer Amir, Stefan D. Anker, Antoni Bayes‐Genis, Michael Boehm, Javed Butler, Ovidiu Chioncel, Gerasimos Filippatos, Finn Gustafsson, Ewa A. Jankowska, Juan Carlos Kaski, Brenda Moura, Mark C. Petrie, Piotr Ponikowski, Amina Rakisheva, Arsen Ristic, Francois Roubille, Gianluigi Savarese, Petar Seferovic, Peter van der Meer, Maurizio Volterrani, Andrew J. Coats, Vijay K. Chopra, Giuseppe Rosano   +25 more
wiley   +1 more source

SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2. [PDF]

, 2011
SIRT1 and SIRT3 are NAD+-dependent protein deacetylases that are evolutionarily conserved across mammals. These proteins are located in the cytoplasm/nucleus and mitochondria, respectively.
Capra, John A, Hirschey, Matthew D, Pollard, Katherine S, Shimazu, Tadahiro, Verdin, Eric   +4 more
core   +3 more sources

Heart failure outcomes and empagliflozin effects in patients with heart failure and reduced ejection fraction in sinus rhythm or atrial fibrillation: Data from EMPEROR‐Reduced

European Journal of Heart Failure, EarlyView.
Empagliflozin effects and heart failure outcomes in patients with heart failure with reduced ejection fraction and atrial fibrillation or sinus rhythm. AF, atrial fibrillation; CV, cardiovascular; eGFR, estimated glomerular filtration rate; HHF, hospitalization for heart failure; KCCQ, Kansas City Cardiomyopathy Questionnaire; SE, standard error ...
Michael Böhm, Javed Butler, Amr Abdin, Gerasimos Filippatos, João Pedro Ferreira, Stuart J. Pocock, Martina Brueckmann, Anne Pernille Ofstad, Elke Schueler, Christoph Wanner, Faiez Zannad, Stefan D. Anker, Milton Packer, on behalf of the EMPEROR‐Reduced Trial Committees and Investigators   +13 more
wiley   +1 more source

The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver [PDF]

, 2019
Secreted frizzled-related protein (sFRP) 4 is an adipokine with increased expression in white adipose tissue from obese subjects with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).
Al-Hasani, Hadi, Barbosa, David, Fahlbusch, Pia, Herzfeld de Wiza, Daniella, Hörbelt, Tina, Knebel, Birgit, Kotzka, Jorg, Lapauw, Bruno, Müller-Wieland, Dirk, Ouwens, Margriet, Thoresen, G Hege, Van de Velde, Frederique, Van Nieuwenhove, Yves   +12 more
core   +1 more source

Bioactive Compounds Derived From Natural Foods Against Metabolic Syndrome and the Advances of Resveratrol and Caffeic Acid in Microbial Cell Factory Production: A Review

Food Frontiers, EarlyView.
Metabolic syndrome is characterized by abdominal obesity, hyperglycemia, dyslipidemia, and hypertension. Bioactive compounds extracted from herbs, tea, and coffee using microbial cell factories, particularly resveratrol and caffeic acid, have demonstrated remarkable potential in the management of metabolic syndrome, offering innovative solutions for ...
Tao Li, Jingjing Shi, Tao Liu, Chongxiang Xue, Lin Han, Mingzhe Zhang, Linhua Zhao, Xiaolin Tong   +7 more
wiley   +1 more source