Results 121 to 130 of about 63,033 (309)

Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria [PDF]

, 2010
Katia Aquilano, Paola Vigilanza, Sara Baldelli, Beatrice Pagliei, Giuseppe Rotilio, Maria Rosa Ciriolo   +5 more
openalex   +1 more source

Effect of Nutraceutical Supplementation and Mediterranean Hypocaloric Diet on Calculated Steatosis Indices and Inflammation: Clinical and In Vitro Evidences

Molecular Nutrition &Food Research, EarlyView.
This retrospective study evaluated the effects of nutraceutical supplementation (NS) and a Mediterranean hypocaloric diet (MHD) in NAFLD patients. Forty‐five overweight/obese subjects followed MHD with or without NS. After 3 months, only the MHD + NS group showed significant improvements in liver steatosis indices and inflammation.
Mariana Di Lorenzo, Luca Pipicelli, Laura Aurino, Concetta Sozio, Anna Palmiero, Domenico Palmieri, Marta Lombardi, Bruna Guida, Mariarosaria Santillo, Maria Serena Lonardo, Giuliana La Rosa, Simona Damiano   +11 more
wiley   +1 more source

Sirtuin 1 in osteoarthritis: Perspectives on regulating glucose metabolism

Pharmacological Research
Osteoarthritis (OA) is a degenerative disease characterised by articular cartilage destruction, and its complex aetiology contributes to suboptimal clinical treatment outcomes.
Zhihao Liao, Xuepei Cai, Yifan Zheng, Jiayu Lin, Xia Yang, Weiyin Lin, Ying Zhang, Xin He, Chufeng Liu   +8 more
doaj   +1 more source

Sirtuin-1 regulation of mammalian metabolism [PDF]

, 2010
Matthew P. Gillum, Derek M. Erion, Gerald I. Shulman   +2 more
openalex   +1 more source

Rutin Enhances Intestinal Barrier Function and Protects Against X‐Ray Radiation‐Induced Barrier Dysfunction in Human Epithelial Caco‐2 Cells

Molecular Nutrition &Food Research, EarlyView.
Rutin enhances intestinal epithelial barrier function by upregulating TJ‐related proteins (ZO‐2, occludin, and claudin‐3), reducing paracellular permeability, and restoring Caco‐2 cell viability impaired by X‐ray radiation. These effects suggest rutin's potential as a natural radioprotective agent for maintaining intestinal barrier integrity under ...
Ha‐Young Park, Jin‐Hee Yu, Soo‐Bin Shin, Young‐Min Kim   +3 more
wiley   +1 more source

Conformational Analysis and NMR Data Assignment of Taraxerone Isolated From Cnidoscolus aconitifolius (Chaya)

Magnetic Resonance in Chemistry, EarlyView.
We report the first complete NMR assignment of taraxerone, a pentacyclic triterpenoid isolated from Cnidoscolus aconitifolius (chaya). Using 2D NMR, DFT, and NBO analysis, we resolved spectral ambiguities due to high‐order couplings and signal overlap. Two Ring A conformers were identified and characterized.
Mónica Díaz‐Fernández, Karla Cahun‐Uicab, Viviana Roche‐Llerena, Leonardo Hernández, Geonel Rodríguez‐Gattorno, Armando Ariza‐Castolo, María A. Fernández‐Herrera   +6 more
wiley   +1 more source

Development and Characterization of a Novel Carbon-11 Labeled Positron Emission Tomography Radiotracer for Neuroimaging of Sirtuin 1 with Benzoxazine-Based Compounds

Drug Design, Development and Therapy
Yanli Wang,1 Yan Liu,1,2 Yongle Wang,1,3 Ping Bai,1 Madelyn Rose Hallisey,1 Breanna Lizeth Varela,1 Anne Siewko,1 Changning Wang,1 Yulong Xu1 1Athinoula A.
Wang Y, Liu Y, Wang Y, Bai P, Hallisey MR, Varela BL, Siewko A, Wang C, Xu Y   +8 more
doaj  

Synthesis and Anticancer Potential of New Benzimidazole Theranostic

ChemistryOpen, EarlyView.
Recent advances have highlighted benzimidazole's importance in anticancer drug discovery. A novel series of benzimidazole analogs is designed and synthesized, with V7 showing broad anticancer activity and selectivity, possibly linked to SIRT2 inhibition.
Sahani Sandalima Uthumange, Muhammad Azri Faiz bin Abdul Zaki, Keng Yoon Yeong   +2 more
wiley   +1 more source

The Relationship of Sirtuin 1 and Sirtuin 2 Expression with Clinicopathological Parameters in Non Small-Cell Lung Carcinomas

Haseki Tıp Bülteni
Aim: Recent studies have shown that sirtuin signaling pathway activation could be a potential therapeutic target for future therapies and biomarkers for predicting prognosis in cancer. We aimed to investigate the association between Sirtuin 1 (SIRT1) and
Fatma Cakmak Kazanci, Nagehan Barisik Ozdemir, Sibel Sensu, Cem Cahit Barisik   +3 more
doaj   +1 more source

Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease

Analytical Cellular Pathology, 2015
Chronic Obstructive Pulmonary disease (COPD) is an inflammatory syndrome that represents an increasing health problem, especially in the elderly population. Drug therapies are symptomatic and inadequate to contrast disease progression and mortality. Thus,
V. Conti, G. Corbi, V. Manzo, G. Pelaia, A. Filippelli, A. Vatrella   +5 more
doaj   +1 more source