Results 141 to 150 of about 63,033 (309)
Enhancing Late‐Life Survival and Mobility via Mitohormesis by Reducing Mitochondrial Calcium Levels
Aging Cell, EarlyView.RNAi knockdown (KD) of mcu‐1 or mitoxantrone treatment lowers mitochondrial Ca2+, extends lifespan, and preserves motility during aging. Benefits require early intervention and involve a transient ROS increase that activates a pmk‐1, daf‐16, and skn‐1 pathway, enhancing stress defense and mitochondrial integrity while reducing early‐life survival ...
Doruntina Bresilla +13 more
wiley +1 more source
The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. [PDF]
, 2019 Transcriptional regulation in eukaryotes occurs at promoter-proximal regions wherein transcriptionally engaged RNA polymerase II (Pol II) pauses before proceeding toward productive elongation.
Ablondi, Eileen +20 more
core +1 more source
Liver molecular networks associated with drinking behavior in nonhuman primates
Alcohol, Clinical and Experimental Research, EarlyView.We identified hepatic molecular networks that differed between light drinkers (LD) and very heavy drinkers (VHD) before they were exposed to alcohol, as well as epigenetic differences between LD and VHD in response to the same amount of alcohol.
Laura A. Cox +11 more
wiley +1 more source
Markers in Infants of Mothers With Asthma and Associations With Respiratory Outcomes
Allergy, EarlyView.In the BILD and BLT cohorts, we compared cord blood proteins in infants of mothers with and without asthma during pregnancy. Groups showed different protein levels. These markers were associated with postnatal lung function, bronchiolitis hospitalization, and asthma.
Carla Rebeca Da Silva Sena +21 more
wiley +1 more source
Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases
Cell Proliferation, EarlyView.HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang +4 more
wiley +1 more source
Cell Proliferation, EarlyView.Prostate‐specific YAP1 overexpression induces pathological BPH phenogenesis. Targeting ROCK1/YAP1 with fasudil and verteporfin alleviates inflammatory BPH lesions. YAP1 orchestrates mitochondrial dysfunction and oxidative stress via suppressing SIRT1 function.
Dongxu Lin +9 more
wiley +1 more source
Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein. [PDF]
, 2013 Lei Liu +4 more
openalex +1 more source
Autophagy in PE: Dispute, Role and Potential Target
Cell Proliferation, EarlyView.Autophagy homeostasis serves as a central hub regulating vascular remodelling during pregnancy. It integrates maternal, genetic, and fetal factors; shapes the functions of immune cells (NK cells, macrophages, and T cells); restrains endothelial inflammatory responses (cytokines, endothelial cell, oxidative/ER stress, and protein aggregation); and ...
Miao Xu +12 more
wiley +1 more source