Results 171 to 180 of about 43,355 (289)

Suppression of Sirtuin-1 Increases IL-6 Expression by Activation of the Akt Pathway During Allergic Asthma [PDF]

, 2017
Lingling Tang, Qingge Chen, Ziyu Meng, Li Sun, Linyun Zhu, Jinjin Liu, Junsheng Hu, Zhenhua Ni, Xiongbiao Wang   +8 more
openalex   +1 more source

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Sirtuin 1 and oral cancer.

Oncology letters
The sirtuins (SIRTs) are a family of highly conserved histone deacetylases (HDACs) consisting of seven members (SIRT1-SIRT7). Over the past few decades, SIRT1 has been the most extensively studied and garnered tremendous attention in the scientific community due to its emerging role in cancer biology.
Shajedul, Islam, Yoshihiro, Abiko, Osamu, Uehara, Itsuo, Chiba   +3 more
openaire   +1 more source

Examining Sirtuin-1 Levels and Inflammation Markers in Behcet's Disease: A Pilot Study. [PDF]

Arch Rheumatol
Ecesoy V, Arıcı H, Ateş FP, Osmanoğlu UÖ, Ecesoy H.   +4 more
europepmc   +1 more source

Screen of Pseudopeptidic Inhibitors of Human Sirtuins 1–3: Two Lead Compounds with Antiproliferative Effects in Cancer Cells

, 2013
Paolo Mellini, Tarja Kokkola, Tiina Suuronen, Heikki S. Salo, Laura Tolvanen, Antonello Mai, Maija Lahtela‐Kakkonen, Elina M. Jarho   +7 more
openalex   +1 more source

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging

Aging Cell, Volume 25, Issue 2, February 2026.
Aging impairs cerebrovascular health by driving mitochondrial dysfunction, oxidative stress, endothelial failure, and neurovascular uncoupling, leading to BBB breakdown and cognitive decline. In contrast, time‐restricted feeding/eating counteracts these mechanisms by restoring mitochondrial function, activating adaptive nutrient‐sensing pathways ...
Madison Milan, Eva Troyano‐Rodriguez, Jennifer Ihuoma, Sharon Negri, Rakesh Rudraboina, Aleksandra Kosmider, Shantipriya Awasthi, Priya Balasubramanian, Shannon Conley, Andriy Yabluchanskiy, Anna Csiszar, Zoltan Ungvari, Rafael de Cabo, Stefano Tarantini   +13 more
wiley   +1 more source

Taurine, Sirtuin-1 and TNF- α levels in different aged adults with periodontitis: a pilot study. [PDF]

BMC Oral Health
Sayedyousef H, Yilmaz O, Ozturk C, Demir B, Toygar HU, Balci N.   +5 more
europepmc   +1 more source

The Role of Sirtuin 1 (SIRT1) in Neurodegeneration. [PDF]

Cureus, 2023
Razick DI, Akhtar M, Wen J, Alam M, Dean N, Karabala M, Ansari U, Ansari Z, Tabaie E, Siddiqui S.   +9 more
europepmc   +1 more source

Glucagon‑like peptide‑1 protects mouse podocytes against high glucose‑induced apoptosis, and suppresses reactive oxygen species production and proinflammatory cytokine secretion, through sirtuin 1 activation in�vitro

, 2018
Jianxia Shi, Qin Huang
openalex   +2 more sources