Results 211 to 220 of about 63,033 (309)

Sirtuin 1 (Sirt1) Overexpression in BaF3 Cells Contributes to Cell Proliferation Promotion, Apoptosis Resistance and Pro-Inflammatory Cytokine Production [PDF]

, 2017
Qian Wang, Chao Yan, Miaomiao Xin, Li Han, Yunqing Zhang, Mingshu Sun   +5 more
openalex   +1 more source

Inhibiting miR-200a-3p Increases Sirtuin 1 and Mitigates Kidney Injury in a Tubular Cell Model of Diabetes and Hypertension-Related Renal Damage. [PDF]

Biomolecules
Martinez-Arroyo O, Flores-Chova A, Mendez-Debaets M, Garcia-Ferran L, Escrivá L, Forner MJ, Redón J, Cortes R, Ortega A.   +8 more
europepmc   +1 more source

A Potential Role for Sirtuin-1 in Alzheimer's Disease: Reviewing the Biological and Environmental Evidence. [PDF]

J Alzheimers Dis Rep, 2023
Mehramiz M, Porter T, O'Brien EK, Rainey-Smith SR, Laws SM.   +4 more
europepmc   +1 more source

ACSS2 involved in acetyl‐CoA synthesis regulates skeletal muscle function

FEBS Letters, Volume 599, Issue 19, Page 2817-2827, October 2025.
The enzyme acyl‐coenzyme A synthetase short‐chain family member‐2 (ACSS2) catalyzes the conversion of acetate to acetyl‐CoA, but its function in skeletal muscle is unclear. We studied ACSS2 deficiency in mouse and fly models. Skeletal muscle from the mouse model showed atrophic fibers, excess lipid, and depleted NADH.
Mekala Gunasekaran, Gloriana Campos, Natalya M. Wells, Khanhlinh Lambuu, Isabelle Draper, Christina A. Pacak, Peter B. Kang   +6 more
wiley   +1 more source

Sirtuin 1 Modulation in Rat Model of Acetaminophen-Induced Hepatotoxicity

, 2015
L. WOJNAROVÁ, Nikolina Kutinová Canová, Hassan Farghali, Tomáš Kučera   +3 more
openalex   +1 more source

Mealworm hydrolysate ameliorates dexamethasone-induced muscle atrophy via sirtuin 1-mediated signaling and Akt pathway. [PDF]

NPJ Sci Food
Kim SM, Kim JY, Jun EM, Jaiswal V, Park EJ, Lee HJ.   +5 more
europepmc   +1 more source

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, Volume 15, Issue 10, Page 1643-1657, October 2025.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Activation of Sirtuin-1 Promotes Renal Fibroblast Activation and Aggravates Renal Fibrogenesis

, 2015
Murugavel Ponnusamy, Michelle A. Zhuang, Xiaoxu Zhou, Evelyn Tolbert, George Bayliss, Ting Zhao, Shougang Zhuang   +6 more
openalex   +1 more source

Blood-brain barrier-penetrating Angiopep-2/Sirtuin 1 nanoparticles rescue sevoflurane neurotoxicity through multi-omics identified necroptosis pathways. [PDF]

J Nanobiotechnology
Chang Y, Zhang X, Zhang S, Qu G.
europepmc   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, Volume 9, Issue 10, October 2025.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source