Results 221 to 230 of about 65,710 (330)

The Role of Sirtuin 1 (SIRT1) in Neurodegeneration. [PDF]

Cureus, 2023
Razick DI, Akhtar M, Wen J, Alam M, Dean N, Karabala M, Ansari U, Ansari Z, Tabaie E, Siddiqui S.   +9 more
europepmc   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Sinomenine Induces G1-Phase Cell Cycle Arrest and Apoptosis in Malignant Glioma Cells Via Downregulation of Sirtuin 1 and Induction of p53 Acetylation [PDF]

, 2018
Xiaoyan He, Mayinur Maimaiti, Jiao Yan, Xuegang Meng, Hongyan Li   +4 more
openalex   +1 more source

SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL

PHYSIOLOGICAL REVIEWS, 2013
Ruben Nogueiras, Kirk M. Habegger, Nilika Chaudhary, Brian Finan, Alexander S. Banks   +4 more
openaire  

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

Brain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu, Biniam Moges Eskeziyaw   +1 more
wiley   +1 more source

Comment on “Renal Protective Effect of Sirtuin 1”

Journal of Diabetes Research, 2015
Kultigin Turkmen
doaj   +1 more source

5-HT3 antagonist, tropisetron, ameliorates age-related renal injury induced by D-galactose in male mice: Up-regulation of sirtuin 1. [PDF]

Atefeh Mirshafa, Mohammad Shokati Sayyad, Ebrahim Mohammadi, Fereshteh Talebpour Amiri, Fatemeh Shaki   +4 more
openalex   +1 more source

The Regulation of the Concentrations of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha and Sirtuin 1 Protein in the Soleus Muscle by Aerobic Exercise Training in Obese Wistar Rats

, 2020
Keyvan Hejazi, Seyyed Reza Attarzadeh Hosseini, Mehrdad Fathi, Mohammad Mosaferi Ziaaldini   +3 more
openalex   +2 more sources

Supplementary Figure 6 from Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth

, 2023
Juan Chen, Bin Zhang, Nathalie Wong, Anthony W.I. Lo, Ka‐Fai To, Anthony W.H. Chan, Margaret H.L. Ng, Cecilia Y.S. Ho, Suk‐Hang Cheng, Paul B.S. Lai, Jun Yu, Ho‐Keung Ng, Ming‐Tat Ling, Ailong Huang, Xue-Fei Cai, Ben C.B. Ko   +15 more
openalex   +1 more source

Targeting the SIRT1‐NAT10‐GABABR1 Axis: A Novel Epitranscriptomic Approach to Mitigate Sevoflurane‐Induced Cognitive Impairment in Aging

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
The study reveals that NAT10 enhances GABABR1 mRNA stability via ac4A modification, leading to excessive inhibitory synaptic activation. In aged rats, sevoflurane contributes to cognitive impairment by inhibiting Sirt1 and neuronal autophagy, which subsequently disrupts energy metabolism.
Xin Xie, Wei Du, Yanmei Zhang, Xiaomin Zhang   +3 more
wiley   +1 more source