Results 251 to 260 of about 65,710 (330)

Pulsed Electromagnetic Field Therapy for Mild‐to‐Moderate Knee Osteoarthritis: A Double‐Blind, Randomized, Placebo‐Controlled Clinical Trial

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Current treatments for knee osteoarthritis (OA) offer limited functional and structural improvements. Compared to age‐ and gender‐matched controls, patients with knee OA show a higher prevalence of muscle weakness, which negatively affects their ability to exercise—a key factor in enhancing physical mobility and delaying disease ...
Kenney Ki Lee Lau, Abbey Ssu Chi Chen, Christine Hoi Yan Fu, Jonathan Patrick Ng, Michael Tim Yun Ong, Patrick Shu Hang Yung, Pauline Po Yee Lui   +6 more
wiley   +1 more source

Sirtuin 1 overexpression in mice preserves insulin and thermogenic responses in subcutaneous inguinal white adipose tissue under proinflammatory conditions. [PDF]

J Physiol Biochem
Vázquez P, Escalona-Garrido C, Pescador N, Hitos AB, González-Moreno D, de Benito-Bueno Á, Sierra-Filardi E, Boya P, Montero-Pedrazuela A, Guadaño-Ferraz A, Valverde ÁM.   +10 more
europepmc   +1 more source

Sirtuin 1 Facilitates Generation of Induced Pluripotent Stem Cells from Mouse Embryonic Fibroblasts through the miR-34a and p53 Pathways

, 2012
Yin Lau Lee, Qian Peng, Sze Wan Fong, Andy C. H. Chen, Ckf Lee, Ernest Hung Yu Ng, András Nagy, William S.B. Yeung   +7 more
openalex   +2 more sources

Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren, Ziqi Shang, Alastair G. Stewart, Ying‐xin Qi, Kai Huang   +4 more
wiley   +1 more source

The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function. [PDF]

Curr Issues Mol Biol
Patyal P, Ameer FS, Verma A, Zhang X, Azhar G, Shrivastava J, Sharma S, Zhang R, Wei JY.   +8 more
europepmc   +1 more source

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review). [PDF]

Biomed Rep
Zheng S, Yang L, Dai Q, Li X, Masuoka T, Lv J.   +5 more
europepmc   +1 more source

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

Mealworm hydrolysate ameliorates dexamethasone-induced muscle atrophy via sirtuin 1-mediated signaling and Akt pathway. [PDF]

NPJ Sci Food
Kim SM, Kim JY, Jun EM, Jaiswal V, Park EJ, Lee HJ.   +5 more
europepmc   +1 more source

Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 Pathway

, 2015
Ying Yin, Xinyuan Li, Xiaojin Sha, Hang Xi, Yafeng Li, Ying Shao, Jietang Mai, Anthony Virtue, Jahaira Lopez‐Pastrana, Shu Meng, Douglas G. Tilley, M. Alexandra Monroy, Eric T. Choi, Craig J. Thomas, Xiaohua Jiang, Hong Wang, Xiao-Feng Yang   +16 more
openalex   +2 more sources