Results 21 to 30 of about 26,472 (265)

Sister-chromatid exchange in 4 human races [PDF]

, 1981
The frequencies of sister-chromatid exchanges (SCE) were investigated in lymphocytes in 32 normal adult individuals of both sexes with no interracial familial backgrounds from Caucasian, American black, oriental and native American races.
Butler, Merlin G.
core   +1 more source

Chromosomal integrity after UV irradiation requires FANCD2-mediated repair of double strand breaks [PDF]

, 2016
Fanconi Anemia (FA) is a rare autosomal recessive disorder characterized by hypersensitivity to inter-strand crosslinks (ICLs). FANCD2, a central factor of the FA pathway, is essential for the repair of double strand breaks (DSBs) generated during fork ...
Bocco, Jose Luis, Di Giorgio, Marina, Federico, Maria Belén, Gottifredi, Vanesa, Paviolo, Natalia Soledad, Radl, Daniela Betiana, Soria, Gastón, Vallerga, María   +7 more
core   +7 more sources

High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast. [PDF]

, 2017
In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule.
Dominska, Margaret, Petes, Thomas D, Yim, Eunice, Yin, Yi   +3 more
core   +3 more sources

Smc5/6: a link between DNA repair and unidirectional replication? [PDF]

, 2008
Of the three structural maintenance of chromosome (SMC) complexes, two directly regulate chromosome dynamics. The third, Smc5/6, functions mainly in homologous recombination and in completing DNA replication.
A Losada, Antony M. Carr, AR Lehmann, B Hu, D Branzei, D Ivanov, DM Sheedy, E Ampatzidou, E Unal, E Unal, EA Andrews, ES Chen, F Onoda, G De Piccoli, GJ Cost, H Morikawa, HB Lindroos, HM Verkade, I Miyabe, J Palecek, J Rouse, J Sergeant, J Torres-Rosell, J Torres-Rosell, JK Chin, Johanne M. Murray, KL Borden, KM Lee, L Strom, L Strom, MI Fousteri, MN Boddy, N Aono, PR Potts, PR Potts, PR Potts, S Pebernard, S Pebernard, SH Harvey, T de Lange, T Kobayashi, T Mengiste, T Morishita, TM Roberts, WH McDonald, WM Thorburn, X Zhao   +46 more
core   +1 more source

Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients [PDF]

, 2012
© 2012 Joksic et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium ...
Guc-Scekic, M, Joksic, G, Joksic, I, Leskovac, A, Ojani, M, Petrovic, S, Slijepcevic, P, Stankovic, A, Surralles, J, Trujillo, JP, Vujic, D, Zivkovic, M   +11 more
core   +3 more sources

The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability

BMC Cell Biology, 2001
Background Bloom syndrome is a rare cancer-prone disorder in which the cells of affected persons have a high frequency of somatic mutation and genomic instability.
Noonan James P, Yankiwski Victor, Neff Norma F   +2 more
doaj   +1 more source

No increase in radiation-induced chromosome aberration complexity detected by m-FISH after culture in the presence of 5’-bromodeoxyuridine [PDF]

, 2006
The thymidine analogue, 5’-bromodeoxyuridine (BrdU), is a known mutagen that is routinely introduced into culture media for subsequent Harlequin stain analysis and determination of cell cycle status.
Anderson, Anderson, Anderson, Anderson, Boei, Cornforth, Dresp, Dudley T. Goodhead, Edwards, George, Goodhead, Griffin, Hawkins, Hsu, Iliakis, Kolin-Gerresheim, Latt, Leonard, Lloyd, Lorimore, Lucas, Moquet, Morimoto, Morton, Natalia D. Sumption, Pala, Perry, Ramsey, Rhona M. Anderson, Ritter, Sachs, Savage, Savage, Schmid, Scott, Simpson, Singleton, Tice, Wang   +38 more
core   +1 more source

Vitamin B12 protects against DNA damage induced by hydrochlorothiazide

Saudi Pharmaceutical Journal, 2018
DNA damage induced by hydrochlorothiazide was previously reported in cultured human lymphocytes. In this study, we aimed to investigate the harmful effects of hydrochlorothiazide on DNA by measuring the spontaneous frequency of sister chromatid exchanges
Karem H. Alzoubi, Erva Bayraktar, Omar Khabour, Sayer I. Al-Azzam   +3 more
doaj   +1 more source

Genome-wide high-resolution mapping of UV-induced mitotic recombination events in Saccharomyces cerevisiae. [PDF]

, 2013
In the yeast Saccharomyces cerevisiae and most other eukaryotes, mitotic recombination is important for the repair of double-stranded DNA breaks (DSBs). Mitotic recombination between homologous chromosomes can result in loss of heterozygosity (LOH).
Petes, Thomas D, Yin, Yi
core   +1 more source

Homologous Recombination: To Fork and Beyond [PDF]

, 2018
Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair ...
Prado Velasco, José Félix
core   +1 more source