Results 91 to 100 of about 659,276 (230)

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins. [PDF]

, 2013
The long term side effects of any newly introduced drug is a subject of intense research, and often raging controversies. One such example is the dipeptidyl peptidase-IV (DPP4) inhibitor used for treating type 2 diabetes, which is inconclusively ...
Chakraborty, Sandeep, Dandekar, Abhaya M, Dutta, Mouparna, Ghosh, Anindya S, Goñi, Félix M, Oda, Masataka, Rao, Basuthkar J, Rendón-Ramírez, Adela, Venkatramani, Ravindra, Ásgeirsson, Bjarni   +9 more
core  

Molecular cloning and biochemical characterization of Xaa-Pro dipeptidyl-peptidase from Streptococcus mutans and its inhibition by anti-human DPP IV drugs

, 2016
Streptococcus mutans harbours an intracellular, human DPP IV-analogous enzyme Xaa-Pro dipeptidyl-peptidase (EC 3.4.14.11). According to previous reports, an extracellular isozyme in S. gordonii and S. suis has been associated with virulence.
De, A, Lupidi, Giulio, Petrelli, Dezemona, Vitali, Luca Agostino   +3 more
core   +1 more source

A Practical Approach to Implementing ICH Q14: Tools for Analytical Quality by Design in Capillary Electrophoresis Method Development

ELECTROPHORESIS, Volume 46, Issue 13-14, Page 933-953, July 2025.
ABSTRACT The ICH Q14 guideline introduces a structured framework for analytical method development based on Analytical Quality by Design (AQbD) principles, aiming to ensure robust, reliable, and fit‐for‐purpose methods throughout the product lifecycle.
Ewoud van Tricht, Cari E. Sänger ‐ van de Griend   +1 more
wiley   +1 more source

Systemic effects of repeated intraocular dexamethasone Intravitreal implant in diabetic patients: a retrospective study [PDF]

, 2017
Introduction: The objective of this study is to evaluate the influence of repeated intraocular dexamethasone implant (Ozurdex) injections on metabolic control in type 2 diabetic patients.
Cifuentes Canorea, Pilar, Donate-López, Juan, García Feijoo, Julián, Megías Fresno, Alicia, Peña-García, Pablo, Ruiz Medrano, Jorge, Valverde Megías, Alicia   +6 more
core   +3 more sources

Apteranthes tuberculata's Antidiabetic Potential: Exploring Phytochemicals, Screening Antioxidant Activity, and Validating DPP‐4 Inhibition Using In Vitro and In Silico Approaches

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
Metabolomics revealed 24 major compounds, mainly glycosides, flavonoids, and triterpenes. Antidiabetic compounds Kaempferol‐7‐O‐rutinoside and Kaempferol‐3‐O‐rutinoside‐7‐O‐glucoside show maximum inhibiting activity for DPP4 protein (in vitro and in silico). Out of 24 compounds, 5 demonstrate no PAINS and break alerts.
Ilham Khan, Shabana Bibi, Junaid Shehzad, Zarqa Riaz, Muhammad Saad Khan, Mansour Ghorbanpour, Murtaza Hasan, Ghazala Mustafa   +7 more
wiley   +1 more source

Development of Photo‐Biocatalytic Redox System for Asymmetric Synthesis of Optically Active Amines Using Blue Light and Transaminases. A Case Study Toward Mavacamten

Advanced Synthesis &Catalysis, Volume 367, Issue 12, June 26, 2025.
Abstract α‐Chiral amines are versatile building blocks for the asymmetric synthesis of optically pure high‐added‐value chemicals, including pharmaceuticals, agrochemicals, and natural products. Herein, we report a one‐pot, two‐step sequential deracemization of racemic sec‐alcohols to optically enriched primary amines throught a photo‐biocatalytic ...
Natalia Antos, Aleksandra Rudzka, Anna Hoser, Tamara Reiter, Wolfgang Kroutil, Paweł Borowiecki   +5 more
wiley   +1 more source

Rosemary Extract as a Potential Anti-Hyperglycemic Agent: Current Evidence and Future Perspectives [PDF]

, 2017
Type 2 diabetes mellitus (T2DM), a disease on the rise and with huge economic burden to health care systems around the globe, results from defects in insulin action (termed insulin resistance) combined with impaired insulin secretion.
Naimi, Madina, Shamshoum, Hesham, Tsiani, Evangelia, Vlavcheski, Filip   +3 more
core   +2 more sources

Newly developed method for the determination of sitagliptin phosphate using rubeanic acid as a precipitating agent via the use of ISNAG continues flow fluorimeter

, 2020
A new, a simple, sensitive and fast developed method for the estimation of sitagliptin phosphate in pure and pharmaceutical drugs (tablet). This method based on the reaction between sitagliptin phosphate and rubeanic acid to form reddish-black ppt, using
K. H. I. Al-saadi
semanticscholar   +1 more source

Elevated serum magnesium associated with SGLT2 inhibitor use in type 2 diabetes patients: a meta-analysis of randomised controlled trials [PDF]

, 2016
Aims/hypothesis By analysing available evidence from randomised controlled trials (RCTs), we aimed to examine whether and to what extent sodium–glucose cotransporter 2 (SGLT2) inhibitors affect serum electrolyte levels in type 2 diabetes patients ...
Del Gobbo, Liana Christine, Li, Yufeng, Song, Yiqing, Tang, Huilin, Zhai, Suodi, Zhang, Jingjing, Zhang, Xi   +6 more
core   +3 more sources

Chiral separation of sitagliptin phosphate enantiomer by HPLC using amylose based chiral stationary phase

Journal of Pharmacy Research, 2013
Abstract Background Although a number of methods are available for evaluating sitagliptin phosphate (SGP), a common method for separation if its potential enantiomer and its possible impurities with good efficiency remains unavailable. With the objective of developing a method for rapid separation with shorter runtimes, a simple, precise, accurate ...
Bhimireddy Venkata Rami Reddy, Nanduri Raman, Badam Sai Kumar, Chintala Rambabu   +3 more
openaire   +1 more source