Results 91 to 100 of about 372,846 (179)

Formulation and Evaluation of Fast Dissolving Oral Films of Sitagliptin Phosphate by Solvent Casting Method

open access: yes, 2023
Abstract The aim of this research work was to formulate fast-dissolving oral films of sitagliptin phosphate for the treatment of diabetes mellitus. The fast dissolving films of sitagliptin phosphate were prepared by solvent casting method using film forming polymers HPMC E 15 and HPMC E 50 cps and PEG and propylene glycol are used as plasticizers. All
openaire   +2 more sources

Fixed-dose combination of sitagliptin and metformin for the treatment of type 2 diabetes

open access: yes, 2009
Jonathan K ReynoldsWashington State University, College of Pharmacy, Pullman, WA, USAAbstract: JanumetTM, a fixed dose combination of sitagliptin/metformin HCL manufactured by Merck Pharmaceuticals, has received US Food and Drug Administration approval ...
Jonathan K Reynolds
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A review of sitagliptin with special emphasis on its use in moderate to severe renal impairment [PDF]

open access: yes, 2013
Vinay S Eligar,1 Stephen C Bain2 1University Hospital of Wales, Cardiff, UK; 2Singleton Hospital, Swansea University, Swansea, UK Abstract: Sitagliptin is the first dipeptidylpeptidase-4 inhibitor to be used in the management of type 2 diabetes.
Bain SC, Eligar VS
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Impact of Sitagliptin on Inflammatory Biomarkers in Type 2 Diabetes Mellitus [PDF]

open access: yes
Background: Type 2 diabetes mellitus (T2DM) is associated with low-grade inflammatory response, which was reported to contribute to insulin resistance. Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is widely used for glycemic control and has ...
Aqeel Meer AL-ZAMILY
core   +2 more sources

The phosphate balance : current developments and future outlook [PDF]

open access: yes, 2011
Phosphate is essential for agricultural production and therefore plays a key role in the global production of food and biofuels. There are no agricultural alternatives for phosphate, and a substantial fraction of our annual phosphate consumption is ...
Enk, R.J., van   +4 more
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Highly Efficient Asymmetric Synthesis of Sitagliptin

open access: yes, 2016
A highly efficient synthesis of sitagliptin, a potent and selective DPP-4 inhibitor for the treatment of type 2 diabetes mellitus (T2DM), has been developed.
Yi Hsiao (771103)   +15 more
core   +1 more source

Sitagliptin attenuates cardiomyopathy by modulating the JAK/STAT signaling pathway in experimental diabetic rats

open access: yes, 2016
Nouf M Al-Rasheed,1 Nawal M Al-Rasheed,1,2 Iman H Hasan,1 Maha A Al-Amin,1 Hanaa N Al-Ajmi,1 Ayman M Mahmoud3 1Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, 2Department of Pharmaceutical Sciences, College of ...
Al-Rasheed NM   +4 more
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Nanoparticle Formulation of Sitagliptin Phosphate: A Novel Therapeutic Option for Diabetes Mellitus [PDF]

open access: yes, 2019
The present study was to formulate sitagliptin phosphate nanoparticles by using enteric coated polymers so that the drug is to be released in the small intestine for absorption, bypass the stomach, therefore to reduce side effects which results in ...
Gowsalya, R C
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Sitagliptin ameliorates oxidative stress in experimental diabetic nephropathy by diminishing the miR-200a/Keap-1/Nrf2 antioxidant pathway

open access: yes, 2017
Esther Civantos,1,2 Enrique Bosch,1 Elisa Ramirez,1 Olha Zhenyukh,1 Jesús Egido,1,2 Oscar Lorenzo,1,2 Sebastián Mas1,2 1Renal, Vascular and Diabetes Research Laboratory, IIS-Fundación Jiménez Díaz, Autonoma University ...
Ramirez E   +6 more
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