The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Playing it safe? a study of the regulation of outdoor play for children and young people in residential care [PDF]
, 2007 The aim of the research was to describe and explain the barriers to, and opportunities for, outdoor play and recreation that exist in residential child care services.
McGuinness, L. +2 more
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FEBS Letters, EarlyView.PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley +1 more source
'Nae too bad': job satisfaction and staff morale in Scottish residential child care [PDF]
, 2005 In 2003, the National Children's Bureau and the Social Education Trust published a report - Better Than You Think -on staff morale, qualifications and retention in residential child care in England (Mainey, 2003a; Mainey, 2003b).
Avan, Ghizala +3 more
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Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
A different way to look at things : the development of consultancy in a residential service for children and young people [PDF]
, 2005 The support of consultancy and the tasks associated with consultation are considered to play a vital role in the development of good practice in residential care and in safeguarding children and young people.
Kendrick, Andrew +1 more
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Fishing in Puddles, Place and Space in Performance Research [PDF]
, 2016 This is the peer reviewed version of the following article: Piasecka, S. (2014). Fishing in Puddles, Place and Space in Performance Research. International Journal of Art & Design Education, 33(2), 235-241.
Alexander +5 more
core +1 more source
Detecting Individual Sites Subject to Episodic Diversifying Selection
PLoS Genetics, 2012 The imprint of natural selection on protein coding genes is often difficult to identify because selection is frequently transient or episodic, i.e. it affects only a subset of lineages.
B. Murrell +5 more
semanticscholar +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Holding safely : guidance for residential child care practitioners and managers about physically restraining children and young people [PDF]
, 2005 Residential child care is intensive and at times very diffificult work. Staff in residential childcare, therefore, need training, advice, supervision and support in undertaking this demanding work, since they are often doing the hardest of social care ...
Davidson, Jennifer +4 more
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