Results 1 to 10 of about 20,169 (226)

Inhibition of Phytosterol Biosynthesis by Azasterols

Molecules, 2020
Inhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of Arabidopsis thaliana sterol profiles upon treatment with a series of azasterols reveals a specific in ...
Sylvain Darnet, Laetitia B B Martin, Pierre Mercier, Franz Bracher, Philippe Geoffroy, Hubert Schaller   +5 more
doaj   +1 more source

Could Lowering Phytosterol Absorption as Part of Lipid-Lowering Therapy Have a Beneficial Effect on Residual Risk?

Metabolites, 2023
Plant sterols are molecules that are structurally similar to cholesterol and provided only as dietary sources (e.g., vegetables, fruits, nuts, cereals) since they cannot be synthesized by humans.
Panagiotis Anagnostis, Vasileios Kotsis, Maciej Banach, Dimitri P. Mikhailidis   +3 more
doaj   +1 more source

Experimental Study For The Effect of β- Sitosterol on the level of Male,s hormones [PDF]

Kirkuk Journal of Science, 2017
The effect of β-Sitosterol to the levels of male,s hormones was carried out in sera of adult male rabbit, twenty eight of local rabbite, weigh aging range between (800-1500)g.
Esraa Ali Abdul kareem, Dr.Abdul MonaimHamadAl-samarrai   +1 more
doaj   +1 more source

Down-regulation of cholesterol biosynthesis in sitosterolemia: diminished activities of acetoacetyl-CoA thiolase, 3-hydroxy-3-methylglutaryl-CoA synthase, reductase, squalene synthase, and 7-dehydrocholesterol Δ7-reductase in liver and mononuclear leukocytes

Journal of Lipid Research, 1998
Sitosterolemia is a recessively inherited disorder characterized by abnormally increased plasma and tissue plant sterol concentrations. Patients have markedly reduced whole body cholesterol biosynthesis associated with suppressed hepatic, ileal, and ...
Akira Honda, Gerald Salen, Lien B. Nguyen, G. Stephen Tint, Ashok K. Batta, Sarah Shefer   +5 more
doaj   +1 more source

Genetic Control of Serum Marinobufagenin in the Spontaneously Hypertensive Rat and the Relationship to Blood Pressure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundWe have investigated serum levels of immunoreactive marinobufagenin (MBG) in 16‐ to 20‐week‐old spontaneously hypertensive rats (SHRs)‐A3 and in the normotensive Wistar‐Kyoto (WKY) rat strain in the absence of salt loading, and we have ...
Renata I. Dmitrieva, Stacy M. Cranford, Peter A. Doris   +2 more
doaj   +1 more source

Steroidal Triterpenes: Design of Substrate-Based Inhibitors of Ergosterol and Sitosterol Synthesis

Molecules, 2009
This article reviews the design and study, in our own laboratory and others, of new steroidal triterpenes with a modified lanosterol or cycloartenol frame.
Jialin Liu, William David Nes
doaj   +1 more source

The Lack of Standardization and Pharmacological Effect Limits the Potential Clinical Usefulness of Phytosterols in Benign Prostatic Hyperplasia

Plants, 2023
The prevalence of benign prostatic hyperplasia (BPH) markedly increases with age. Phytotherapeutic approaches have been developed over time owing to the adverse side effects of conventional medications such as 5-reductase inhibitors and α1-adrenergic ...
Mădălina-Georgiana Buț, George Jîtcă, Silvia Imre, Camil Eugen Vari, Bianca Eugenia Ősz, Carmen-Maria Jîtcă, Amelia Tero-Vescan   +6 more
doaj   +1 more source

Effects of diet and metamorphosis upon the sterol composition of the butterfly Morpho peleides

Journal of Lipid Research, 2006
Whole body sterol metabolism in insects has seldom been studied. We were able to design an appropriate study at a butterfly farm in Belize. We collected six larvas of butterfly (Morpho peleides), their food (leaves of Pterocarpus bayessii), and their ...
William E. Connor, Yingming Wang, Mike Green, Don S. Lin   +3 more
doaj   +1 more source

Hyperabsorption and retention of campestanol in a sitosterolemic homozygote: comparison with her mother and three control subjects

Journal of Lipid Research, 2000
We measured the percent absorption, turnover, and distribution of campestanol (24-methyl-5α-cholestan-3β-ol) in a sitosterolemic homozygote, her obligate heterozygous mother, and three healthy human control subjects.
Gerald Salen, Guorong Xu, G.S. Tint, A.K. Batta, Sarah Shefer   +4 more
doaj   +1 more source

Serum plant sterols and biliary cholesterol secretion in humans

Journal of Lipid Research, 2002
Ratios of cholestanol, campesterol, and sitosterol to cholesterol in serum are known to reflect cholesterol absorption efficiency. Here, a possible link between these ratios and biliary secretion rates of cholesterol was investigated.
Bernhard Lindenthal, Thomas Sudhop, Peter Schiedermaier, Mohamed Agnan, Tilman Sauerbruch, Klaus von Bergmann   +5 more
doaj   +1 more source