Results 51 to 60 of about 95,199 (265)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Situated digital ecosystems: the key to driving the AI revolution in Education

Ensaio
This reflective conceptual paper explores the imperative need to create integrated and situated institutional digital ecosystems for the effective and transformative implementation of artificial intelligence (AI) in Higher Education.
Milena Patricia Rojas, Andrés Chiappe, Felipe Sepúlveda   +2 more
doaj   +1 more source

The effect of a latchkey situation on a child’s educational success

South African Journal of Education, 2011
Self care is one of the options for parents in need of after school care for their children. In certain studies self care is seen as detrimental to development and academic performance, but in other studies children do fairly well notwithstanding their latchkey situation — self care could teach young people a sense of personal responsibility and ...
Venter, Elza, Rambau, Eunice
openaire   +4 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Teacher learning in second language teacher education: a socially-situated perspective

Revista Brasileira de Linguística Aplicada, 2001
Ultrapassadando as tradições históricas e teóricas que têm definido a educação de professores de segunda língua na América do Norte nos últimos vinte cinco anos, argumentamos neste artigo em favor de uma reconceituação do conhecimento de base da educação
Karen E. Johnson, Donald Freeman
doaj  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Situated Cognition Principles Increase Students’ Likelihood of Knowledge Transfer in an Online Information Literacy Course

Evidence Based Library and Information Practice, 2016
A Review of: Catalano, A. (2015). The effect of a situated learning environment in a distance education information literacy course. The Journal of Academic Librarianship, 41(5), 653-659.
Peace Ossom Williamson
doaj  

The impact of multi-person virtual reality competitive learning on anatomy education: a randomized controlled study

BMC Medical Education, 2020
Background Anatomy is one of the core subjects in medical education. Students spend considerable time and effort on learning the requisite anatomy knowledge.
Yi-Chun Du, Shih-Chen Fan, Li-Cheng Yang
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source