Results 221 to 230 of about 3,038,180 (280)

An N-terminal amphipathic helix governs activity and conformational dynamics of Nramp metal transporters. [PDF]

J Biol Chem
Jafari M, Zhao H, Zhang Y, Wang T, Merz KM, Hu J.   +5 more
europepmc   +1 more source

Design of a Novel Diamine Biosensor to Guide the Engineering of Escherichia coli for Cadaverine Overproduction

Advanced Science, EarlyView.
A high‐throughput screening platform was established by integrating an in vivo cadaverine biosensor with a fluorescence‐activated cell sorting (FACS) system. Biosensor‐driven specific exporter tuning, pathway optimization and genome‐wide target mining were conducted to maximize cadaverine production in Escherichia coli.
Jia Feng, Getao Liu, Ding Ma, Jiaxiang Yuan, Xinyi Zhang, Weihao Wang, Chen Ma, Yang Liao, Siyuan Gao, Lei Qin, Jiao Feng, Sheng Xu, Xin Wang, Kequan Chen   +13 more
wiley   +1 more source

The atomic structure of human dystrophin spectrin-like repeat 24. [PDF]

Acta Crystallogr F Struct Biol Commun
Streeter O, Shi K, Bui H, Aihara H, Ervasti JM, Evans R, Muretta JM.   +6 more
europepmc   +1 more source

Colossal Magnetic‐Field‐Induced Anomalous Hall Conductivity in a Kagome Antiferromagnet YMn6Sn6

Advanced Science, EarlyView.
Magnetic‐field‐driven spin canting in the kagome antiferromagnet YMn6Sn6${\rm YMn}_6{\rm Sn}_6$ reshapes flat and Dirac bands near the Fermi level, redistributing Berry curvature and producing colossal anomalous Hall conductivity. The study reveals how magnetic configuration and clean‐limit skew scattering cooperate to amplify Hall transport, offering ...
Minhyuk Choi, Hoil Kim, Minki Sung, Hyeongwoo Seo, Joonyoung Choi, Jaeyoung Kim, Younjung Jo, Han Woong Yeom, Kyung‐Hwan Jin, Jun Sung Kim   +9 more
wiley   +1 more source

Activation mechanism of the full-length histidine kinase LvrB from pathogenic Leptospira. [PDF]

Nat Commun
Agustoni E, Mechaly A, Dalla Rizza J, Beriashvili D, Pluhackova K, Isaikina P, Trajtenberg F, Müntener T, Wunder EA, Ko AI, Schirmer T, Buschiazzo A, Hiller S.   +12 more
europepmc   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Direct Cytosolic Delivery of Amphiphilic Framework Nucleic Acids for RNA Interference. [PDF]

Angew Chem Int Ed Engl
Lin L, Jiao K, Wei B, Zhou F, Wang Y, Liu X, Tang Z, Wang L, Zhu Y, Guo L, Fan C, Li J.   +11 more
europepmc   +1 more source

Magnetically Guided Macrophage Immunobots Coordinate Iron‐Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy

Advanced Science, EarlyView.
Magnetically guided macrophage immunobots integrate active tumor targeting with immunometabolic therapy. After systemic administration, magnetic actuation enhances immunobot retention and tumor penetration, while LPS‐functionalized FePt microrollers sustain M1‐like polarization through inflammatory and iron‐amplified oxidative signaling and trigger ...
Xirui Zeng, Yingfei Zhang, Chong Wu, Qijia Duan, Mengqi Fan, Kuan Wang, Shirong Cai, Immihan Ceren Yasa   +7 more
wiley   +1 more source

Bacterial Chemoreceptors Transmit Stimulus Signals Through Coupled Entropic Switches. [PDF]

J Mol Biol
Flack CE, Parkinson JS.
europepmc   +1 more source