Results 101 to 110 of about 4,358,031 (284)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Big Thicket National Preserve and Big Thicket Association Anniversary Flyer

, 1999
Schedule of events for the 25th anniversary of Big Thicket National Preserve and 35th anniversary of the Big Thicket Association, happening ...
Big Thicket National Preserve, U.S. National Park Service
core  

Improving sustainability index through the implementation of total productive maintenance for the bending process in electrical manufacturing

OPSI
The significant losses caused by breakdowns in the bending machine directly affect Company X. Machines that frequently experience breakdowns can also adversely affect machine efficiency due to the need for component replacements, which contradicts the ...
Rifdah Shumaesi, Dian Mardi Safitri, Amal Witonohadi   +2 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Analisa Efektivitas Mesin Filling Menggunakan Metode Overall Equipment Effectiveness dan Six Big Losses

Physical Sciences, Life Science and Engineering
Setiap perusahaan perlu menjaga peralatan penunjang proses produksinya. PT. XYZ merupakan perusahaan berbasis fast moving consumer good, perusahaan ini memiliki permasalahan terhadap salah satu mesin filling yang sering mengalami kegagalan proses yang mengakibatkan waste.
Yusuf Alfari, Hana Wahyuni
openaire   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Big Thicket National Preserve Field Research Station Pamphlet

, 2000
Pamphlet with information on the Field Research Station in Big Thicket National Preserve, including a map and information to reserve the ...
Big Thicket National Preserve
core  

Total Productive Maintenance (TPM) Analysis on Lathe Machines using the Overall Equipment Effectiveness Method and Six Big Losses

Journal of Physics: Conference Series, 2019
C.V. Oni Jaya is a company engaged in manufacturing by producing / modifying motorcycle parts. This company is inseparable from problems related to the effectiveness of equipment or machinery. One of the causes of the disruption of the production process is the lack of maintenance management on the machine.
Akhmad Sutoni, Widy Setyawan, Taufik Munandar   +2 more
openaire   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source