Results 111 to 120 of about 208,922 (315)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Analisis Penerapan Total Productive Maintenance (TPM) Menggunakan Overall Equipment Efectiveness (OEE) Dan Six Big Losses Pada Mesin Cold Leveller PT. KPS [PDF]

, 2019
PT. KPS is one steel company in Indonesia that produces steel products in the form of slab and plate that is marketed in the country up to foreign countries. Cold leveller machine is a machine that serves to flatten the surface of the plate.
Anthony, Muhamad Bob
core   +1 more source

Electronic and visual identification devices for adult goats reared in semi-intensive system

Revista Brasileira de Zootecnia, 2014
This study intended to evaluate three identification devices for adult goats reared in semi-intensive system. They were (1) the ruminal bolus, electronic identification device composed of non-toxic ceramic and weighing 74.4 g; (2) small ear tag on left ...
Luciana Helena Kowalski, Alda Lúcia Gomes Monteiro, Fernando Hentz, Odilei Rogerio Prado, Carlos Henrique Kulik, Sergio Rodrigo Fernandes, Cláudio José Araújo da Silva   +6 more
doaj   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Penerapan Total Productive Maintenance dengan menggunakan metode OEE pada turbin uap Type C5 DS II – GVS

Jurnal Energi Dan Manufaktur, 2018
Abstrak Secara harfiah, tidak ada barang ataupun benda buatan manusia yang tidak dapat rusak, mesin turbin uap misalnya. Namun kerusakan tersebut dapat dicegah dengan metode perawatan yang tepat demi masa pakai yang lebih lama.
Joel Bastanta Perangin Angin, Evin Dunan Manurung, Alfian Hamsi Siregar   +2 more
doaj  

Improving sustainability index through the implementation of total productive maintenance for the bending process in electrical manufacturing

OPSI
The significant losses caused by breakdowns in the bending machine directly affect Company X. Machines that frequently experience breakdowns can also adversely affect machine efficiency due to the need for component replacements, which contradicts the ...
Rifdah Shumaesi, Dian Mardi Safitri, Amal Witonohadi   +2 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Analisis Overall Equipment Efectiveness (Oee) Dalam Meminimalisir Six Big Losses Pada Mesin Produksi Pengolahan Minyak Kelapa Di UD. Hidup Baru [PDF]

, 2019
UD. Hidup Baru merupakan sebuah Perusahaan Industri yang bergerak dalam produksi minyak kelapa. Bahan mentah pembuatan minyak goreng ini didistribusikan ke Medan.
Syukriah, Syukriah, Kurnadi, Budhi Santri Kusuma, Bakhtiar, Bakhtiar   +2 more
core  

Preventive maintenance approach for improving the efficiency of SCM Olimpic K-800 Auto Edgeband machine [PDF]

EPJ Web of Conferences
This study aims to improve the efficiency of the SCM Olimpic K-800 Auto Edgeband machine at PT ABC, a furniture manufacturing company. From January to June 2024, frequent machine breakdowns disrupted production flow and reduced productivity.
Indriartiningtias Retno, Akhmad Sabarudin, Azmi Alamsyah Muhammad, Arya Ardana Devano, Purwoko Sugeng, Mualim   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source