Results 161 to 170 of about 3,869 (216)

Skatole-induced p38 and JNK activation coordinately upregulates, whereas AhR activation partially attenuates TNFα expression in intestinal epithelial cells.

Bioscience, biotechnology and biochemistry, 2023
Increased TNFα expression in IECs plays a major role in the development and progression of IBD and CRC. The present study aimed to clarify the relationship between TNFα and skatole, a tryptophan-derived gut microbiota metabolite.
Koichi Kurata, Katsunori Ishii, Yoshihito Koto, Kazuma Naito, Kana Yuasa, H. Shimizu   +5 more
semanticscholar   +1 more source

Magnolol-driven microbiota modulation elicits changes in tryptophan metabolism resulting in reduced skatole formation in pigs

Journal of Hazardous Materials
Skatole of gut origin has garnered significant attention as a malodorous pollutant due to its escalating emissions, recalcitrance to biodegradation and harm to animal and human health.
Yuanfei Li, Chunlong Mu, Changyi Zhang   +2 more
exaly   +2 more sources

2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A22

Xenobiotica; the fate of foreign compounds in biological systems, 2023
The 2-oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole (a contributor to boar taint) mediated by minipig liver microsomes and recombinant P450 enzymes expressed in bacterial membranes were investigated. At low substrate concentrations of
Y. Uno, Saho Morikuni, N. Murayama, H. Yamazaki   +3 more
semanticscholar   +1 more source

Skatole: A thin red line between its benefits and toxicity.

Biochimie, 2022
Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and is produced by certain flowers. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream.
Eliška Zgarbová, R. Vrzal
semanticscholar   +1 more source

Biodegradation of skatole by Burkholderia sp. IDO3 and its successful bioaugmentation in activated sludge systems

Environmental Research, 2020
Skatole is the key malodorous compound in livestock and poultry waste and wastewater with a low odor threshold. It not only causes serious nuisance to residents and workers, but also poses threat to the environment and human health due to its biotoxicity
Qiao Ma, Hui Qu, Shuzhen Li
exaly   +2 more sources

THE OXIDATION OF SKATOLE WITH POTASSIUM PERSULFATE

Canadian Journal of Biochemistry, 1965
The oxidation of skatole with potassium persulfate has been shown to produce a mixture of potassium 4-, 5-, 6-, and 7-skatolyl sulfates, together with 3-methyl-oxindole, o-aminoacetophenone, o-formamidoacetophenone, and a number of unidentified products.
R A, Heacock, M E, Mahon
openaire   +2 more sources

Exogenous influences on skatole formation in the pig

, 2015
Castration of male piglets without anesthesia and analgesia has been an ancient and traditional practice in several European countries to prevent problems with boar taint. The commencement of the National Protection of Animals Act on 13th July 2013 intends to end castration without anesthesia in Germany by 2019. In Europe, the goal is to end castration
Wesoly, Raffael
openaire   +3 more sources

Removal of malodorant skatole by two enriched microbial consortia: Performance, dynamic, function prediction and bacteria isolation.

Science of the Total Environment, 2020
Malodor emission has become one of the major challenges in animal husbandry. Skatole, one of the most offensive odorous compounds, can cause several diseases to organisms and is resistant to biodegradation.
Q. Ma, Shengwei Liu, Shuzhen Li, Jiabao Hu, M. Tang, Yeqing Sun   +5 more
semanticscholar   +1 more source

Relationship between oxidation and conjugation metabolism of skatole in pig liver and concentrations of skatole in fat.

Journal of Animal Science, 1998
High concentrations of skatole in fat of some intact male pigs are a major cause of boar taint. In this study, we investigated the effect of oxidative and conjugative metabolism of skatole in liver on the concentrations of skatole in the fat of intact male pigs.
J, Babol, E J, Squires, K, Lundström
openaire   +2 more sources

Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.

Biochemical and Biophysical Research Communications - BBRC, 2019
Intestinal bacteria produce skatole (3-methylindole) from tryptophan in dietary proteins and ingesting large quantities of animal protein is associated with increased fecal skatole concentrations.
Koichi Kurata, H. Kawahara, K. Nishimura, M. Jisaka, K. Yokota, H. Shimizu   +5 more
semanticscholar   +1 more source