Results 11 to 20 of about 460,487 (267)

Targeting healthspan to optimally combat non-communicable disease in an aging world

Sports Medicine and Health Science, 2019
Human lifespan and life expectancy have increased worldwide, but the number of years that we spend free of chronic or debilitating disorders, known as healthspan, has not shifted along with increased lifespan.
Joshua C. Drake, Zhen Yan
doaj   +1 more source

Prions in skeletal muscle [PDF]

Proceedings of the National Academy of Sciences, 2002
Considerable evidence argues that consumption of beef products from cattle infected with bovine spongiform encephalopathy (BSE) prions causes new variant Creutzfeldt–Jakob disease. In an effort to prevent new variant Creutzfeldt–Jakob disease, certain “specified offals,” including neural and lymphatic tissues, thought to contain ...
BOSQUE PJ, RYOU C, TELLING G, PERETZ D, Legname, Giuseppe, DEARMOND SJ, PRUSINER SB   +6 more
openaire   +5 more sources

Acute conversion of patient-derived Duchenne muscular dystrophy iPSC into myotubes reveals constitutive and inducible over-activation of TGFβ-dependent pro-fibrotic signaling

Skeletal Muscle, 2020
Background In Duchenne muscular dystrophy (DMD), DYSTROPHIN deficiency exposes myofibers to repeated cycles of contraction/degeneration, ultimately leading to muscle loss and replacement by fibrotic tissue.
Luca Caputo, Alice Granados, Jessica Lenzi, Alessandro Rosa, Slimane Ait-Si-Ali, Pier Lorenzo Puri, Sonia Albini   +6 more
doaj   +1 more source

Skeletal muscle ultrasound [PDF]

Neurological Research, 2011
Muscle ultrasound is a convenient technique to visualize normal and pathological muscle tissue as it is non-invasive and real-time. Neuromuscular disorders give rise to structural muscle changes that can be visualized with ultrasound: atrophy can be objectified by measuring muscle thickness, while infiltration of fat and fibrous tissue increases muscle
Pillen, S., Alfen, N. van
openaire   +3 more sources

Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers

Skeletal Muscle, 2023
Duchenne muscular dystrophy (DMD) is caused by the lack of dystrophin, a cytoskeletal protein essential for the preservation of the structural integrity of the muscle cell membrane.
Dongwoo Hahn, Joseph D. Quick, Brian R. Thompson, Adelyn Crabtree, Benjamin J. Hackel, Frank S. Bates, Joseph M. Metzger   +6 more
doaj   +1 more source

Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4

Skeletal Muscle, 2016
Background Nuclear bodies, such as nucleoli, PML bodies, and SC35 speckles, are dynamic sub-nuclear structures that regulate multiple genetic and epigenetic processes. Additional regulation is provided by RNA/DNA handling proteins, notably TDP-43 and FUS,
Sachiko Homma, Mary Lou Beermann, Bryant Yu, Frederick M. Boyce, Jeffrey Boone Miller   +4 more
doaj   +1 more source

Bioelectrical impedance vectors analysis (BIVA) in older adults according to level of physical activity and muscle strength: a comparison of classic and specific approaches

Frontiers in Aging
IndroductionBioelectrical Impedance Analysis (BIA) is a widely used method to assess body composition. Traditional BIA models use predictive equations without considering individual characteristics such as age, sex, and activity level.
Ismael Figueiredo Rabelo, Shannon Farrell, Kieran F. Reid, Vanessa Ribeiro Dos Santos, Melissa Antunes, Vitor Cabrera Batista, Andreia Bauermann-Vieira, Luís Alberto Gobbo   +7 more
doaj   +1 more source

Normal inflammation and regeneration of muscle following injury require osteopontin from both muscle and non-muscle cells

Skeletal Muscle, 2019
Background Osteopontin is secreted by skeletal muscle myoblasts and macrophages, and its expression is upregulated in muscle following injury. Osteopontin is present in many different structural forms, which vary in their expression patterns and effects ...
Dimuthu K. Wasgewatte Wijesinghe, Eleanor J. Mackie, Charles N. Pagel   +2 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Nicotinamide phosphoribosyltransferase (Nampt) in Lateral Hypothalamus Maintains Skeletal Muscle Functions Through Lactate‐Mediated Calcium Signalling in Male Mice

Journal of Cachexia, Sarcopenia and Muscle
Background Sarcopenia has become an urgent socioeconomic problem in rapidly aging societies. The pathogenesis of age‐associated sarcopenia is not fully understood and no effective therapeutic strategies have been developed to date.
Takahiro Eguchi, Keiko Kabetani, Naoki Ito   +2 more
doaj   +1 more source