Results 61 to 70 of about 898,304 (304)

Correction to: Expressing a Z-disk nebulin fragment innebulin-deficient mouse muscle: effects on muscle structure and function

Skeletal Muscle, 2020
Following the publication of this paper [1], it was brought to the authors’ attention that one of the contributing authors was left off of the paper. The authors apologize for the unfortunate oversight.
Frank Li, Justin Kolb, Julie Crudele, Paola Tonino, Zaynab Hourani, John E. Smith, Jeffrey S. Chamberlain, Henk Granzier   +7 more
doaj   +1 more source

11 beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle [PDF]

, 2009
OBJECTIVE: Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown.
A. Yu, Abdallah, Aguirre, Araki, C. Lenaghan, D. Laber, D. M. Smith, Danielsson, Djurhuus, Draznin, Fraser, G. Convey, G. G. Lavery, Geraghty, Giorgino, Giorgino, Giorgino, Hanada, I. J. Bujalska, J. K. Sethi, J. W. Tomlinson, Jang, K. Hegyi, Kido, Kim, L. L. Gathercole, Larsson, Liu, M. Sherlock, M  ssig, P. M. Stewart, R. Mayers, S. A. Morgan, Saad, van Staa, Watson, Whorwood, Zhang   +37 more
core   +3 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Differential requirement for satellite cells during overload-induced muscle hypertrophy in growing versus mature mice

Skeletal Muscle, 2017
Background Pax7+ satellite cells are required for skeletal muscle fiber growth during post-natal development in mice. Satellite cell-mediated myonuclear accretion also appears to persist into early adulthood.
Kevin A. Murach, Sarah H. White, Yuan Wen, Angel Ho, Esther E. Dupont-Versteegden, John J. McCarthy, Charlotte A. Peterson   +6 more
doaj   +1 more source

The likely effects of thermal climate change on vertebrate skeletal muscle mechanics with possible consequences for animal movement and behaviour [PDF]

, 2019
Climate change can involve alteration in the local temperature that an animal is exposed to, which in turn may affect skeletal muscle temperature.
Abrahams, Allan, Allen, Altringham, Altringham, Angilletta, Angilletta, Barany, Beever, Bennett, Bennett, Bennett, Berchtold, Bernal, Bershitsky, Brenner, Caiozzo, Chown, Colombini, Cotton, Coughlin, Coupland, Crowley, De Ruiter, Debold, Decostre, Donley, Donley, Edwards, Evans, Ferguson, Fitts, Gabriel, Glanville, Herrel, Herrel, Hertz, Higham, Hill, Hochachka, Hou, Hudson, Huey, Husak, IPCC, James, James, James, James, John-Alder, Johnson, Johnson, Johnston, Johnston, Jones, Josephson, Lailvaux, Le Roy, Mantle, Marsh, Mautz, Michelangeli, Miles, Niehaus, Nocella, Olberding, Perry, Pinder, Place, Rall, Ranatunga, Ranatunga, Ranatunga, Rand, Reilly, Rome, Roots, Rummel, Seebacher, Seebacher, Seebacher, Seebacher, Seebacher, Seebacher, Segal, Segre, Shuman, Somero, Stein, Storey, Swoap, Syme, Symonds, Vanhooydonck, Watkins, West, Wilson, Wilson, Wilson, Wilson, Wilson   +100 more
core   +1 more source

RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. [PDF]

, 2020
Elevated cytoplasmic [Ca2+] is characteristic in severe skeletal and cardiac myopathies, diabetes, and neurodegeneration, and partly results from increased Ca2+ leak from sarcoplasmic reticulum stores via dysregulated ryanodine receptor (RyR) channels ...
Bers, Donald M, Cornea, Razvan L, Janicek, Kevyn A, Launikonis, Bradley S, Rebbeck, Robyn T, Singh, Daniel P, Thomas, David D   +6 more
core   +2 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Preclinical rationale for entinostat in embryonal rhabdomyosarcoma

Skeletal Muscle, 2019
Background Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric cancer population. Survival among metastatic RMS patients has remained dismal yet unimproved for years.
Narendra Bharathy, Noah E. Berlow, Eric Wang, Jinu Abraham, Teagan P. Settelmeyer, Jody E. Hooper, Matthew N. Svalina, Zia Bajwa, Martin W. Goros, Brian S. Hernandez, Johannes E. Wolff, Ranadip Pal, Angela M. Davies, Arya Ashok, Darnell Bushby, Maria Mancini, Christopher Noakes, Neal C. Goodwin, Peter Ordentlich, James Keck, Douglas S. Hawkins, Erin R. Rudzinski, Atiya Mansoor, Theodore J. Perkins, Christopher R. Vakoc, Joel E. Michalek, Charles Keller   +26 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Se-Jin Lee, myostatin discoverer, elected to the National Academy of Science

Skeletal Muscle, 2012
Se-Jin Lee was elected member to the National Academy of Sciences on 28 April 2012. Dr Lee is responsible for the discovery of myostatin, a critical regulator of skeletal muscle mass and function.
Glass David J, Spiegelman Bruce M
doaj   +1 more source