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Disuse Atrophy of Human Skeletal Muscles
Archives of Neurology, 1969DISUSE ATROPHY is a term frequently and glibly used by clinicians and pathologists alike when faced with a nonspecific muscular atrophy. Unfortunately for both, this is usually a diagnosis of exclusion. Histological changes in cases of pure disuse atrophy in human skeletal muscles are wanting.
A N, Patel, Z A, Razzak, D K, Dastur
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Intracellular signaling during skeletal muscle atrophy
Muscle & Nerve, 2005AbstractA variety of conditions lead to skeletal muscle atrophy including muscle inactivity or disuse, multiple disease states (i.e., cachexia), fasting, and age‐associated atrophy (sarcopenia). Given the impact on mobility in the latter conditions, inactivity could contribute in a secondary manner to muscle atrophy.
Susan C, Kandarian, Robert W, Jackman
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Skeletal Muscle Atrophy in Bioengineered Skeletal Muscle: A New Model System
Tissue Engineering Part A, 2013Skeletal muscle atrophy has been well characterized in various animal models, and while certain pathways that lead to disuse atrophy and its associated functional deficits have been well studied, available drugs to counteract these deficiencies are limited.
Peter H U, Lee, Herman H, Vandenburgh
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2017
Skeletal muscle atrophy occurs when there is a higher concentration of the transcription factor Forkhead box protein O1 (Foxo-1) inside the nucleus of a skeletal muscle cell than in the cytoplasm. Within a skeletal muscle cell, only dephosphorylated Foxo-1 can enter the nucleus, while only phosphorylated Foxo-1 can exit the nucleus.
Furman, Samantha +2 more
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Skeletal muscle atrophy occurs when there is a higher concentration of the transcription factor Forkhead box protein O1 (Foxo-1) inside the nucleus of a skeletal muscle cell than in the cytoplasm. Within a skeletal muscle cell, only dephosphorylated Foxo-1 can enter the nucleus, while only phosphorylated Foxo-1 can exit the nucleus.
Furman, Samantha +2 more
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Space travel directly induces skeletal muscle atrophy
The FASEB Journal, 1999ABSTRACT Space travel causes rapid and pronounced skeletal muscle wasting in humans that reduces their long‐term flight capabilities. To develop effective countermeasures, the basis of this atrophy needs to be better understood.
H, Vandenburgh +4 more
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JAMA: The Journal of the American Medical Association, 1942
Mammalian skeletal muscle is served by a number of different types of nerve fibers. Some represent the central and others the autonomic nervous system. Diagrammatic representation of the component parts of skeletal muscle innervation has been attempted in figure 1.
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Mammalian skeletal muscle is served by a number of different types of nerve fibers. Some represent the central and others the autonomic nervous system. Diagrammatic representation of the component parts of skeletal muscle innervation has been attempted in figure 1.
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The molecular basis of skeletal muscle atrophy
American Journal of Physiology-Cell Physiology, 2004Skeletal muscle atrophy attributable to muscular inactivity has significant adverse functional consequences. While the initiating physiological event leading to atrophy seems to be the loss of muscle tension and a good deal of the physiology of muscle atrophy has been characterized, little is known about the triggers or the molecular signaling events ...
Robert W, Jackman, Susan C, Kandarian
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Journal of Cellular Physiology, 2020
Skeletal muscle atrophy is characterized by the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. An increase in the expression of two muscle‐specific E3 ligases, atrogin‐1 and MuRF‐1, and oxidative stress are involved in ...
J. Ábrigo +10 more
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Skeletal muscle atrophy is characterized by the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. An increase in the expression of two muscle‐specific E3 ligases, atrogin‐1 and MuRF‐1, and oxidative stress are involved in ...
J. Ábrigo +10 more
semanticscholar +1 more source
Phosphodiesterase 4 inhibition reduces skeletal muscle atrophy
Muscle & Nerve, 2005AbstractSeveral GTP‐binding protein (G‐protein)–coupled receptors that signal through Gαs (GTP‐binding protein α stimulatory) and the cyclic adenosine monophosphate (cAMP) pathway increase skeletal muscle mass. In order to further evaluate the role of the cAMP pathway in the regulation of skeletal muscle mass, we utilized inhibitors of ...
Richard T, Hinkle +4 more
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Role of ATF4 in skeletal muscle atrophy
Current Opinion in Clinical Nutrition & Metabolic Care, 2017Here, we discuss recent work focused on the role of activating transcription factor 4 (ATF4) in skeletal muscle atrophy.Muscle atrophy involves and requires widespread changes in skeletal muscle gene expression; however, the transcriptional regulatory proteins responsible for those changes are not yet well defined. Recent work indicates that some forms
Christopher M, Adams +2 more
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